Search Results - "Howe, Jonathan R."

Revisiting the bacterial mutagenicity assays: Report by a workgroup of the International Workshops on Genotoxicity Testing (IWGT) by Schoeny, Rita, Cross, Kevin P., DeMarini, David M., Elespuru, Rosalie, Hakura, Atsushi, Levy, Dan D., Williams, Richard V., Zeiger, Errol, Escobar, Patricia A., Howe, Jonathan R., Kato, Masayuki, Lott, Jasmin, Moore, Martha M., Simon, Stephanie, Stankowski, Leon F., Sugiyama, Kei-ichi, van der Leede, Bas-jan M.

“…•International Workshop on Genotoxicity Testing met in 2017 to address OECD TG471.•Strains sub-group concluded that most mutagens would be detected with fewer…”
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The results of five coded compounds: genistein, metaproterenol, rotenone, p-anisidine and resorcinol tested in the pH 6.7 Syrian hamster embryo cell morphological transformation assay by Harvey, James S., Howe, Jonathan R., Lynch, Anthony M., Rees, Robert W.

“…The pH 6.7 Syrian hamster embryo (SHE) cell morphological transformation assay is a short-term in vitro test that has been used to predict rodent…”
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Resolution of Historically Discordant Ames Test Negative / Rodent Carcinogenicity Positive N-nitrosamines using a Sensitive, OECD-aligned Design by Thomas, Dean N, Wills, John W, Burman, Mark, Williams, Abbie N, Harte, Danielle S G, Buckley, Ruby A, Urquhart, Mike W, Bretonnet, Anne-Sophie, Jeffries, Benjamin, White, Angela T, Harvey, James S, Howe, Jonathan R, Lynch, Anthony M

“…The in vitro Bacterial Reverse Mutation (Ames) Test is crucial for evaluating the mutagenicity of pharmaceutical impurities. For N-nitrosamines (NAs)…”
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