Search Results - "Howe, Jacob W"

Glacial–interglacial Nd isotope variability of North Atlantic Deep Water modulated by North American ice sheet by Zhao, Ning, Oppo, Delia W., Huang, Kuo-Fang, Howe, Jacob N. W., Blusztajn, Jerzy, Keigwin, Lloyd D.

“…The Nd isotope composition of seawater has been used to reconstruct past changes in the contribution of different water masses to the deep ocean. In the…”
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Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E

“…Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a platform to…”
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Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils by Patterson, Joseph R., Duffy, Megan F., Kemp, Christopher J., Howe, Jacob W., Collier, Timothy J., Stoll, Anna C., Miller, Kathryn M., Patel, Pooja, Levine, Nathan, Moore, Darren J., Luk, Kelvin C., Fleming, Sheila M., Kanaan, Nicholas M., Paumier, Katrina L., El-Agnaf, Omar M.A., Sortwell, Caryl E.

“…Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration of the nigrostriatal system…”
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Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions by Stoll, Anna C., Kemp, Christopher J., Patterson, Joseph R., Howe, Jacob W., Steece-Collier, Kathy, Luk, Kelvin C., Sortwell, Caryl E., Benskey, Matthew J.

“…Parkinson's disease (PD) pathology is characterized by alpha-synuclein (α-syn) aggregates, degeneration of dopamine neurons in the substantia nigra pars…”
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Publisher Correction: Glacial–interglacial Nd isotope variability of North Atlantic Deep Water modulated by North American ice sheet by Zhao, Ning, Oppo, Delia W., Huang, Kuo-Fang, Howe, Jacob N. W., Blusztajn, Jerzy, Keigwin, Lloyd D.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils by Patterson, Joseph R., Kochmanski, Joseph, Stoll, Anna C., Kubik, Michael, Kemp, Christopher J., Duffy, Megan F., Thompson, Kajene, Howe, Jacob W., Cole-Strauss, Allyson, Kuhn, Nathan C., Miller, Kathryn M., Nelson, Seth, Onyekpe, Christopher U., Beck, John S., Counts, Scott E., Bernstein, Alison I., Steece-Collier, Kathy, Luk, Kelvin C., Sortwell, Caryl E.

“…Examination of early phases of synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both understanding disease…”
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North Atlantic Deep Water Production during the Last Glacial Maximum by Howe, Jacob N. W., Piotrowski, Alexander M., Noble, Taryn L., Mulitza, Stefan, Chiessi, Cristiano M., Bayon, Germain

“…Changes in deep ocean ventilation are commonly invoked as the primary cause of lower glacial atmospheric CO 2 . The water mass structure of the glacial deep…”
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Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein by Patterson, Joseph R., Hirst, Warren D., Howe, Jacob W., Russell, Christopher P., Cole-Strauss, Allyson, Kemp, Christopher J., Duffy, Megan F., Lamp, Jared, Umstead, Andrew, Kubik, Michael, Stoll, Anna C., Vega, Irving E., Steece-Collier, Kathy, Chen, Yi, Campbell, Anne C., Nezich, Catherine L., Glajch, Kelly E., Sortwell, Caryl E.

“…β2-adrenoreceptor (β2AR) agonists have been associated with a decreased risk of developing Parkinson’s disease (PD) and are hypothesized to decrease expression…”
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Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E

“…After publication of the original article [1] it was noted that the name of author, D. Luke Fisher, was erroneously typeset in both the PDF and online formats…”
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Atlantic deep water provenance decoupled from atmospheric CO2 concentration during the lukewarm interglacials by Howe, Jacob N. W., Piotrowski, Alexander M.

“…Ice core records show that atmospheric CO 2 concentrations and Antarctic temperature were lower during the ‘lukewarm interglacials’ from 800 to 430 ka than the…”
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Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS by Miller, Kathryn M, Patterson, Joseph R, Kochmanski, Joseph, Kemp, Christopher J, Stoll, Anna C, Onyekpe, Christopher U, Cole-Strauss, Allyson, Steece-Collier, Kathy, Howe, Jacob W, Luk, Kelvin C, Sortwell, Caryl E

“…Preclinical studies show a link between subthalamic nucleus (STN) deep brain stimulation (DBS) and neuroprotection of nigrostriatal dopamine (DA) neurons,…”
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Antarctic intermediate water circulation in the South Atlantic over the past 25,000years by Howe, Jacob N W, Piotrowski, Alexander M, Oppo, Delia W, Huang, Kuo-Fang, Mulitza, Stefan, Chiessi, Cristiano M, Blusztajn, Jurek

“…Antarctic Intermediate Water is an essential limb of the Atlantic meridional overturning circulation that redistributes heat and nutrients within the Atlantic…”
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Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein by Howe, Jacob W., Sortwell, Caryl E., Duffy, Megan F., Kemp, Christopher J., Russell, Christopher P., Kubik, Michael, Patel, Pooja, Luk, Kelvin C., El-Agnaf, Omar M.A., Patterson, Joseph R.

“…Alpha-synuclein (α-syn) preformed fibril (PFF)-induced pathology can be used to study the features and progression of synucleinopathies, such as Parkinson's…”
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Reconstruction of east–west deep water exchange in the low latitude Atlantic Ocean over the past 25,000 years by Howe, Jacob N.W., Piotrowski, Alexander M., Hu, Rong, Bory, Aloys

“…Radiogenic neodymium isotopes have been used as a water mass mixing proxy to investigate past changes in ocean circulation. Here we present a new depth…”
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Similar mid-depth Atlantic water mass provenance during the Last Glacial Maximum and Heinrich Stadial 1 by Howe, Jacob N.W., Huang, Kuo-Fang, Oppo, Delia W., Chiessi, Cristiano M., Mulitza, Stefan, Blusztajn, Jurek, Piotrowski, Alexander M.

“…The delivery of freshwater to the North Atlantic during Heinrich Stadial 1 (HS1) is thought to have fundamentally altered the operation of Atlantic meridional…”
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Atlantic deep water provenance decoupled from atmospheric CO 2 concentration during the lukewarm interglacials by Howe, Jacob N W, Piotrowski, Alexander M

“…Ice core records show that atmospheric CO concentrations and Antarctic temperature were lower during the 'lukewarm interglacials' from 800 to 430 ka than the…”
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Antarctic intermediate water circulation in the South Atlantic over the past 25,000 years by Howe, Jacob N. W., Piotrowski, Alexander M., Oppo, Delia W., Huang, Kuo‐Fang, Mulitza, Stefan, Chiessi, Cristiano M., Blusztajn, Jurek

“…Antarctic Intermediate Water is an essential limb of the Atlantic meridional overturning circulation that redistributes heat and nutrients within the Atlantic…”
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