Search Results - "Howe, Erin"

Targets of miR-200c mediate suppression of cell motility and anoikis resistance by Howe, Erin N, Cochrane, Dawn R, Richer, Jennifer K

“…miR-200c and other members of the miR-200 family promote epithelial identity by directly targeting ZEB1 and ZEB2, which repress E-cadherin and other genes…”
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CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10 by Guldner, Ian H., Wang, Qingfei, Yang, Lin, Golomb, Samantha M., Zhao, Zhuo, Lopez, Jacqueline A., Brunory, Abigail, Howe, Erin N., Zhang, Yizhe, Palakurthi, Bhavana, Barron, Martin, Gao, Hongyu, Xuei, Xiaoling, Liu, Yunlong, Li, Jun, Chen, Danny Z., Landreth, Gary E., Zhang, Siyuan

“…Brain metastasis (br-met) develops in an immunologically unique br-met niche. Central nervous system-native myeloid cells (CNS-myeloids) and…”
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Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide by Cochrane, Dawn R, Bernales, Sebastián, Jacobsen, Britta M, Cittelly, Diana M, Howe, Erin N, D'Amato, Nicholas C, Spoelstra, Nicole S, Edgerton, Susan M, Jean, Annie, Guerrero, Javier, Gómez, Francisco, Medicherla, Satyanarayana, Alfaro, Iván E, McCullagh, Emma, Jedlicka, Paul, Torkko, Kathleen C, Thor, Ann D, Elias, Anthony D, Protter, Andrew A, Richer, Jennifer K

“…The androgen receptor (AR) is widely expressed in breast cancers and has been proposed as a therapeutic target in estrogen receptor alpha (ER) negative breast…”
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Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer by Palakurthi, Bhavana, Fross, Shaneann R., Guldner, Ian H., Aleksandrovic, Emilija, Liu, Xiyu, Martino, Anna K., Wang, Qingfei, Neff, Ryan A., Golomb, Samantha M., Lewis, Cheryl, Peng, Yan, Howe, Erin N., Zhang, Siyuan

“…Chemotherapy prior to immune checkpoint blockade (ICB) treatment appears to improve ICB efficacy but resistance to ICB remains a clinical challenge and is…”
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The miR-200 and miR-221/222 microRNA Families: Opposing Effects on Epithelial Identity by Howe, Erin N., Cochrane, Dawn R., Richer, Jennifer K.

“…Carcinogenesis is a complex process during which cells undergo genetic and epigenetic alterations. These changes can lead tumor cells to acquire…”
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Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth by Howe, Erin N., Burnette, Miranda D., Justice, Melanie E., Schnepp, Patricia M., Hedrick, Victoria, Clancy, James W., Guldner, Ian H., Lamere, Alicia T., Li, Jun, Aryal, Uma K., D’Souza-Schorey, Crislyn, Zartman, Jeremiah J., Zhang, Siyuan

“…Breast cancer brain metastases (BCBM) have a 5-20 year latency and account for 30% of mortality; however, mechanisms governing adaptation to the brain…”
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miR-200c targets a NF-κB up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer by Howe, Erin N, Cochrane, Dawn R, Cittelly, Diana M, Richer, Jennifer K

“…Anoikis is apoptosis initiated upon cell detachment from the native extracellular matrix. Since survival upon detachment from basement membrane is required for…”
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MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents by Cochrane, Dawn R, Spoelstra, Nicole S, Howe, Erin N, Nordeen, Steven K, Richer, Jennifer K

“…The transcription factor ZEB1 is normally not expressed in epithelial cells. When inappropriately expressed in carcinomas, ZEB1 initiates epithelial to…”
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GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment by Schnepp, Patricia M, Lee, Dennis D, Guldner, Ian H, O'Tighearnaigh, Treasa K, Howe, Erin N, Palakurthi, Bhavana, Eckert, Kaitlyn E, Toni, Tiffany A, Ashfeld, Brandon L, Zhang, Siyuan

“…The impact of altered amino acid metabolism on cancer progression is not fully understood. We hypothesized that a metabolic transcriptome shift during…”
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Restoration of miR-200c to ovarian cancer reduces tumor burden and increases sensitivity to paclitaxel by Cittelly, Diana M, Dimitrova, Irina, Howe, Erin N, Cochrane, Dawn R, Jean, Annie, Spoelstra, Nicole S, Post, Miriam D, Lu, Xian, Broaddus, Russell R, Spillman, Monique A, Richer, Jennifer K

“…A therapeutic intervention that could decrease tumor burden and increase sensitivity to chemotherapy would have a significant impact on the high morbidity rate…”
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Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer by Ni, Yingjia, Schmidt, Keon R., Werner, Barnes A., Koenig, Jenna K., Guldner, Ian H., Schnepp, Patricia M., Tan, Xuejuan, Jiang, Lan, Host, Misha, Sun, Longhua, Howe, Erin N., Wu, Junmin, Littlepage, Laurie E., Nakshatri, Harikrishna, Zhang, Siyuan

“…Lacking targetable molecular drivers, triple-negative breast cancer (TNBC) is the most clinically challenging subtype of breast cancer. In this study, we…”
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Empowering certified nurse's aides to improve quality of work life through a team communication program by Howe, Erin E.

“…The purpose of this pilot study was to explore the impact of a certified nurse's aide (CNA)-led interdisciplinary teamwork and communication intervention on…”
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MicroRNA regulation of epithelial plasticity in cancer by D’Amato, Nicholas C, Howe, Erin N, Richer, Jennifer K

“…Highlights ► miRNA expression levels may induce or permit carcinoma cells to undergo EMT or MET in response to microenvironmental stimuli. ► Numerous miRNAs…”
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Loss of miR-200c : A Marker of Aggressiveness and Chemoresistance in Female Reproductive Cancers by Cochrane, Dawn R., Howe, Erin N., Spoelstra, Nicole S., Richer, Jennifer K.

“…We focus on unique roles of miR-200c in breast, ovarian, and endometrial cancers. Members of the miR-200 family target ZEB1, a transcription factor which…”
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Aged Breast Extracellular Matrix Drives Mammary Epithelial Cells to an Invasive and Cancer‐Like Phenotype by Bahcecioglu, Gokhan, Yue, Xiaoshan, Howe, Erin, Guldner, Ian, Stack, M. Sharon, Nakshatri, Harikrishna, Zhang, Siyuan, Zorlutuna, Pinar

“…Age is a major risk factor for cancer. While the importance of age related genetic alterations in cells on cancer progression is well documented, the effect of…”
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Tumor-induced Stromal STAT1 Accelerates Breast Cancer via Deregulating Tissue Homeostasis by Zellmer, Victoria R, Schnepp, Patricia M, Fracci, Sarah L, Tan, Xuejuan, Howe, Erin N, Zhang, Siyuan

“…The tumor microenvironment (TME), the dynamic tissue space in which the tumor exists, plays a significant role in tumor initiation, and is a key contributor in…”
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Progestin regulated miRNAs that mediate progesterone receptor action in breast cancer by Cochrane, Dawn R., Jacobsen, Britta M., Connaghan, Keith D., Howe, Erin N., Bain, David L., Richer, Jennifer K.

“…► Progestin stimulates rapid regulation of miRNAs. ► ATP1B1 is upregulated by progesterone receptor at its promoter. ► ATP1B1 is repressed by miR-29, a…”
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Combined Scaffold Evaluation and Systems‐Level Transcriptome‐Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes by Rodriguez, Kevin X., Howe, Erin N., Bacher, Emily P., Burnette, Miranda, Meloche, Jennifer L., Meisel, Jayda, Schnepp, Patricia, Tan, Xuejuan, Chang, Mayland, Zartman, Jeremiah, Zhang, Siyuan, Ashfeld, Brandon L.

“…With evolutionary drug resistance impacting efforts to treat disease, the need for small molecules that exhibit novel molecular mechanisms of action is…”
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ZEB1 expression in type I vs type II endometrial cancers: a marker of aggressive disease by Singh, Meenakshi, Spoelstra, Nicole S, Jean, Annie, Howe, Erin, Torkko, Kathleen C, Clark, Hilda R, Darling, Douglas S, Shroyer, Kenneth R, Horwitz, Kathryn B, Broaddus, Russell R, Richer, Jennifer K

“…Zinc-finger E-box-binding homeobox 1 (ZEB1) is a transcription factor containing two clusters of Kruppel-type zinc-fingers, by which it binds E-box-like…”
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Metformin-Induced Killing of Triple-Negative Breast Cancer Cells Is Mediated by Reduction in Fatty Acid Synthase via miRNA-193b by Wahdan-Alaswad, Reema S., Cochrane, Dawn R., Spoelstra, Nicole S., Howe, Erin N., Edgerton, Susan M., Anderson, Steven M., Thor, Ann D., Richer, Jennifer K.

“…The anti-diabetic drug metformin (1,1-dimethylbiguanide hydrochloride) reduces both the incidence and mortality of several types of cancer. Metformin has been…”
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