Search Results - "Howe, Connor A"

Nitric oxide is fundamental to neurovascular coupling in humans by Hoiland, Ryan L., Caldwell, Hannah G., Howe, Connor A., Nowak‐Flück, Daniela, Stacey, Benjamin S., Bailey, Damian M., Paton, Julian F. R., Green, Daniel J., Sekhon, Mypinder S., Macleod, David B., Ainslie, Philip N.

“…Key points Preclinical models have demonstrated that nitric oxide is a key component of neurovascular coupling; this has yet to be translated to humans. We…”
Get full text

Internal carotid and brachial artery shear‐dependent vasodilator function in young healthy humans by Carr, Jay M. J. R., Hoiland, Ryan L., Caldwell, Hannah G., Coombs, Geoff B., Howe, Connor A., Tremblay, Joshua C., Green, Daniel J., Ainslie, Philip N.

“…Key points Brachial artery (BA) shear‐mediated dilatation is a widely used assessment of vascular function with links to coronary artery health and…”
Get full text

Arterial carbon dioxide and bicarbonate rather than pH regulate cerebral blood flow in the setting of acute experimental metabolic alkalosis by Caldwell, Hannah G., Howe, Connor A., Chalifoux, Carter J., Hoiland, Ryan L., Carr, Jay M. J. R., Brown, Courtney V., Patrician, Alexander, Tremblay, Joshua C., Panerai, Ronney B., Robinson, Thompson G., Minhas, Jatinder S., Ainslie, Philip N.

“…Key points We investigated the influence of arterial PCO2 (PaCO2) with and without acutely elevated arterial pH and bicarbonate ([HCO3–]) on cerebral blood…”
Get full text

Evidence for temperature‐mediated regional increases in cerebral blood flow during exercise by Caldwell, Hannah G., Coombs, Geoff B., Howe, Connor A., Hoiland, Ryan L., Patrician, Alexander, Lucas, Samuel J.E., Ainslie, Philip N.

“…Key points Aerobic exercise elicits increases in cerebral blood flow (CBF), as well as core body temperature; however, the isolated influence of temperature on…”
Get full text

UBC‐Nepal expedition: phenotypical evidence for evolutionary adaptation in the control of cerebral blood flow and oxygen delivery at high altitude by Hoiland, Ryan L., Howe, Connor A., Carter, Howard H., Tremblay, Joshua C., Willie, Chris K., Donnelly, Joseph, MacLeod, David B., Gasho, Chris, Stembridge, Mike, Boulet, Lindsey M., Niroula, Shailesh, Ainslie, Philip N.

“…Key points Sherpa have lived in the Nepal Himalaya for 25–40 thousand years and display positive physiological adaptations to hypoxia. Sherpa have previously…”
Get full text

Global Reach 2018: reduced flow-mediated dilation stimulated by sustained increases in shear stress in high-altitude excessive erythrocytosis by Tremblay, Joshua C, Coombs, Geoff B, Howe, Connor A, Vizcardo-Galindo, Gustavo A, Figueroa-Mujíca, Rómulo J, Bermudez, Daniela, Tymko, Michael M, Villafuerte, Francisco C, Ainslie, Philip N, Pyke, Kyra E

“…Excessive erythrocytosis [EE; hemoglobin concentration (Hb) ≥ 21 g/dL in adult men] is a maladaptive high-altitude pathology associated with increased…”
Get more information

Haemoconcentration and cerebral blood flow: absence of evidence is not evidence of absence by Howe, Connor A.

Get full text

The 2018 Global Research Expedition on Altitude Related Chronic Health (Global REACH) to Cerro de Pasco, Peru: an Experimental Overview by Tymko, Michael M., Hoiland, Ryan L., Tremblay, Joshua C., Stembridge, Mike, Dawkins, Tony G., Coombs, Geoff B., Patrician, Alexander, Howe, Connor A., Gibbons, Travis D., Moore, Jonathan P., Simpson, Lydia L., Steinback, Craig D., Meah, Victoria L., Stacey, Benjamin S., Bailey, Damian M., MacLeod, David B., Gasho, Christopher, Anholm, James D., Bain, Anthony R., Lawley, Justin S., Villafuerte, Francisco C., Vizcardo‐Galindo, Gustavo, Ainslie, Philip N.

“…New Findings What is the central question of this study? Herein, a methodological overview of our research team's (Global REACH) latest high altitude research…”
Get full text

The effect of α1‐adrenergic blockade on post‐exercise brachial artery flow‐mediated dilatation at sea level and high altitude by Tymko, Michael M., Tremblay, Joshua C., Hansen, Alex B., Howe, Connor A., Willie, Chris K., Stembridge, Mike, Green, Daniel J., Hoiland, Ryan L., Subedi, Prajan, Anholm, James D., Ainslie, Philip N.

“…Key points Our objective was to quantify endothelial function (via brachial artery flow‐mediated dilatation) at sea level (344 m) and high altitude (3800 m) at…”
Get full text

UBC‐Nepal Expedition: Haemoconcentration underlies the reductions in cerebral blood flow observed during acclimatization to high altitude by Howe, Connor A., Ainslie, Philip N., Tremblay, Joshua C., Carter, Howard H., Patrician, Alex, Stembridge, Mike, Williams, Alex, Drane, Aimee L., Delorme, Eric, Rieger, Mathew G., Tymko, Michael M., Gasho, Chris, Santoro, Antoinette, MacLeod, David B., Hoiland, Ryan L.

“…New Findings What is the central question of this study? The aim was to evaluate the degree to which increases in haematocrit alter cerebral blood flow and…”
Get full text

Validation of a Noninvasive Assessment of Pulmonary Gas Exchange During Exercise in Hypoxia by Howe, Connor A., MacLeod, David B., Wainman, Liisa, Oliver, Samuel J., Ainslie, Philip N.

“…Pulmonary gas exchange efficiency, determined by the alveolar-to-arterial Po2 difference (A-aDo2), progressively worsens during exercise at sea-level; this…”
Get full text

Ventilatory and cerebrovascular regulation and integration at high-altitude by Hoiland, Ryan L., Howe, Connor A., Coombs, Geoff B., Ainslie, Philip N.

“…Ascent to high-altitude elicits compensatory physiological adaptations in order to improve oxygenation throughout the body. The brain is particularly…”
Get full text

The human blood transcriptome exhibits time-of-day-dependent response to hypoxia: Lessons from the highest city in the world by Manella, Gal, Ezagouri, Saar, Champigneulle, Benoit, Gaucher, Jonathan, Mendelson, Monique, Lemarie, Emeline, Stauffer, Emeric, Pichon, Aurélien, Howe, Connor A., Doutreleau, Stéphane, Golik, Marina, Verges, Samuel, Asher, Gad

“…High altitude exposes humans to hypobaric hypoxia, which induces various physiological and molecular changes. Recent studies point toward interaction between…”
Get full text

Cerebrovascular reactivity to carbon dioxide is not influenced by variability in the ventilatory sensitivity to carbon dioxide by Howe, Connor A., Caldwell, Hannah G., Carr, Jay, Nowak‐Flück, Daniela, Ainslie, Philip N., Hoiland, Ryan L.

“…New Findings What is the central question of this study? Do differing magnitudes of ventilation influence cerebrovascular CO2 reactivity and the cerebral blood…”
Get full text

Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and S-nitrosothiol mediated signal transduction by Hoiland, Ryan L, MacLeod, David B, Stacey, Benjamin S, Caldwell, Hannah G, Howe, Connor A, Nowak-Flück, Daniela, Carr, Jay MJR, Tymko, Michael M, Coombs, Geoff B, Patrician, Alexander, Tremblay, Joshua C, Van Mierlo, Michelle, Gasho, Chris, Stembridge, Mike, Sekhon, Mypinder S, Bailey, Damian M, Ainslie, Philip N

“…Cerebral hypoxic vasodilation is poorly understood in humans, which undermines the development of therapeutics to optimize cerebral oxygen delivery. Across…”
Get full text

Global REACH 2018: High Blood Viscosity and Hemoglobin Concentration Contribute to Reduced Flow-Mediated Dilation in High-Altitude Excessive Erythrocytosis by Tremblay, Joshua C, Hoiland, Ryan L, Howe, Connor A, Coombs, Geoff B, Vizcardo-Galindo, Gustavo A, Figueroa-Mujíca, Rómulo J, Bermudez, Daniela, Gibbons, Travis D, Stacey, Benjamin S, Bailey, Damian M, Tymko, Michael M, MacLeod, David B, Gasho, Chris, Villafuerte, Francisco C, Pyke, Kyra E, Ainslie, Philip N

“…Excessive erythrocytosis (EE; hemoglobin concentration [Hb] ≥21 g/dL in adult males) is associated with increased cardiovascular risk in highlander Andeans. We…”
Get full text

Nitric oxide contributes to cerebrovascular shear‐mediated dilatation but not steady‐state cerebrovascular reactivity to carbon dioxide by Hoiland, Ryan L., Caldwell, Hannah G., Carr, Jay M. J. R., Howe, Connor A., Stacey, Benjamin S., Dawkins, Tony, Wakeham, Denis J., Tremblay, Joshua C., Tymko, Michael M., Patrician, Alexander, Smith, Kurt J., Sekhon, Mypinder S., MacLeod, David B., Green, Daniel J., Bailey, Damian M., Ainslie, Philip N.

“…Cerebrovascular CO2 reactivity (CVR) is often considered a bioassay of cerebrovascular endothelial function. We recently introduced a test of cerebral…”
Get full text

Is the Cushing mechanism a dynamic blood pressure-stabilizing system? Insights from Granger causality analysis of spontaneous blood pressure and cerebral blood flow by Saleem, Saqib, Teal, Paul D, Howe, Connor A, Tymko, Michael M, Ainslie, Philip N, Tzeng, Yu-Chieh

“…Blood pressure (BP) regulation is widely recognized as being integral to the control of end-organ perfusion, but it remains unclear whether end-organ perfusion…”
Get more information

Cerebral O2 and CO2 transport in isovolumic haemodilution: Compensation of cerebral delivery of O2 and maintenance of cerebrovascular reactivity to CO2 by Carr, Jay MJR, Ainslie, Philip N, MacLeod, David B, Tremblay, Joshua C, Nowak-Flück, Daniela, Howe, Connor A, Stembridge, Mike, Patrician, Alexander, Coombs, Geoff B, Stacey, Benjamin S, Bailey, Damian M, Green, Daniel J, Hoiland, Ryan L

“…This study investigated the influence of acute reductions in arterial O2 content (CaO2) via isovolumic haemodilution on global cerebral blood flow (gCBF) and…”
Get full text

Hemorheological, cardiorespiratory, and cerebrovascular effects of pentoxifylline following acclimatization to 3,800 m by Steele, Andrew R, Howe, Connor A, Gibbons, Travis D, Foster, Katharine, Williams, Alexandra M, Caldwell, Hannah G, Brewster, L Madden, Duffy, Jennifer, Monteleone, Justin A, Subedi, Prajan, Anholm, James D, Stembridge, Mike, Ainslie, Philip N, Tremblay, Joshua C

“…Pentoxifylline is a nonselective phosphodiesterase inhibitor used for the treatment of peripheral artery disease. Pentoxifylline acts through cyclic adenosine…”
Get more information