Search Results - "Howdeshell, Kembra L"

A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner by Howdeshell, Kembra L., Wilson, Vickie S., Furr, Johnathan, Lambright, Christy R., Rider, Cynthia V., Blystone, Chad R., Hotchkiss, Andrew K., Gray, Leon Earl

“…Phthalate diesters are chemicals to which humans are ubiquitously exposed. Exposure to certain phthalates during sexual differentiation causes reproductive…”
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Systematic evidence mapping informs a class-based approach to assessing personal care products and pubertal timing by Taylor, Kyla W, Howdeshell, Kembra L, Bommarito, Paige A, Sibrizzi, Christopher A, Blain, Robyn B, Magnuson, Kristen, Lemeris, Courtney, Tracy, Wren, Baird, Donna D, Jackson, Chandra L, Gaston, Symielle A, Rider, Cynthia V, Walker, Vickie R, Rooney, Andrew A

“…Personal care products (PCPs) contain many different compounds and are a source of exposure to endocrine disrupting chemicals (EDCs), including phthalates and…”
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Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory rats by Howdeshell, Kembra L., Rider, Cynthia V., Wilson, Vickie S., Gray, L. Earl

“…Phthalate esters are high production volume chemicals used to impart flexibility to polyvinyl chloride products as well as other applications. In the male…”
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Estrogenic Chemicals in Plastic and Oral Contraceptives Disrupt Development of the Fetal Mouse Prostate and Urethra by Timms, Barry G., Howdeshell, Kembra L., Barton, Lesley, Bradley, Sarahann, Richter, Catherine A., Frederick S. vom Saal, Bern, Howard A.

“…Exposure of human fetuses to man-made estrogenic chemicals can occur through several sources. For example, fetal exposure to ethinylestradiol occurs because…”
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Pubertal Administration of DEHP Delays Puberty, Suppresses Testosterone Production, and Inhibits Reproductive Tract Development in Male Sprague-Dawley and Long-Evans Rats by Noriega, Nigel C., Howdeshell, Kembra L., Furr, Jonathan, Lambright, Christy R., Wilson, Vickie S., Gray, L. Earl

“…Although is clear that exposure to high dosage levels of some phthalates delays the onset of puberty in the male rat, it has been hypothesized that low levels…”
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Society for birth defects research and prevention's multidisciplinary research needs workshop 2022: A call to action by Basu, Madhumita, Howdeshell, Kembra L., Rasmussen, Sonja A., Rychlik, Kristal A., Knudsen, Thomas B., Shuey, Dana L., Slikker, William

“…The Society for Birth Defects Research and Prevention (BDRP) strives to understand and protect against potential hazards to developing embryos, fetuses,…”
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Cumulative Effects of In Utero Administration of Mixtures of “Antiandrogens” on Male Rat Reproductive Development by Rider, Cynthia V., Wilson, Vickie S., Howdeshell, Kembra L., Hotchkiss, Andrew K., Furr, Johnathan R., Lambright, Christy R., Earl Gray, L.

“…Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 Food Quality Protection Act (FQPA) required the Environmental…”
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Exposure to a Low Dose of Bisphenol A during Fetal Life or in Adulthood Alters Maternal Behavior in Mice by Palanza, Paola, Howdeshell, Kembra L., Parmigiani, Stefano, Frederick S. vom Saal

“…Maternal behavior in mammals is the result of a complex interaction between the lactating dam and her developing offspring. Slight perturbations of any of the…”
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Cumulative effects of antiandrogenic chemical mixtures and their relevance to human health risk assessment by Howdeshell, Kembra L., Hotchkiss, Andrew K., Gray, L. Earl

“…•Many chemicals disrupt androgen-sensitive male reproductive development in the rat.•Mixtures of antiandrogenic chemicals act via dose addition, regardless of…”
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A Model of the Development of the Brain as a Construct of the Thyroid System by Howdeshell, Kembra L.

“…Thyroid hormone is essential for normal brain development. However, little is known about the molecular and cellular mechanisms that mediate thyroid hormone…”
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Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate by Hannas, Bethany R, Lambright, Christy S, Furr, Johnathan, Howdeshell, Kembra L, Wilson, Vickie S, Gray, Jr, Leon E

“…Several phthalate esters have been linked to the Phthalate Syndrome, affecting male reproductive development when administered to pregnant rats during in utero…”
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Comment on "Evidence Synthesis of Observational Studies in Environmental Health: Lessons Learned from a Systematic Review on Traffic-Related Air Pollution" by Taylor, Kyla W, Howdeshell, Kembra L, Singh, Anisha, Walker, Vickie R, Wang, Amy, Boyles, Abee E, Beverly, Brandiese E J, Rooney, Andrew A

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Dose Addition Models Based on Biologically Relevant Reductions in Fetal Testosterone Accurately Predict Postnatal Reproductive Tract Alterations by a Phthalate Mixture in Rats by Howdeshell, Kembra L, Rider, Cynthia V, Wilson, Vickie S, Furr, Johnathan R, Lambright, Christy R, Gray, Jr, L Earl

“…Challenges in cumulative risk assessment of anti-androgenic phthalate mixtures include a lack of data on all the individual phthalates and difficulty…”
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Developing a database of systematic reviews of animal studies by Langendam, Miranda W., Magnuson, Kristen, Williams, Ashley R., Walker, Vickie R., Howdeshell, Kembra L., Rooney, Andrew A., Hooijmans, Carlijn R.

“…Systematic reviews (SRs) are common practice in clinical and public health research, but less common in non-human animal research. Systematic reviews of animal…”
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In utero phthalate effects in the female rat: A model for MRKH syndrome by Hannas, Bethany R., Howdeshell, Kembra L., Furr, Johnathan, Earl Gray, L.

“…•A chemically induced animal model of the human MRKH syndrome.•A phthalate syndrome in female rats: uterine and vaginal agenesis.•A phthalate mixture disrupts…”
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Gestational and Lactational Exposure to Ethinyl Estradiol, but not Bisphenol A, Decreases Androgen-Dependent Reproductive Organ Weights and Epididymal Sperm Abundance in the Male Long Evans Hooded Rat by Howdeshell, Kembra L., Furr, Johnathan, Lambright, Christy R., Wilson, Vickie S., Ryan, Bryce C., Gray, L. Earl

“…Many chemicals released into the environment are capable of disrupting normal sex steroid balance, including the oral contraceptive ethinyl estradiol (EE) and…”
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Cumulative Effects of Dibutyl Phthalate and Diethylhexyl Phthalate on Male Rat Reproductive Tract Development: Altered Fetal Steroid Hormones and Genes by Howdeshell, Kembra L., Furr, Johnathan, Lambright, Christy R., Rider, Cynthia V., Wilson, Vickie S., Gray, L. Earl

“…Exposure to plasticizers di(n-butyl) phthalate (DBP) and diethylhexyl phthalate (DEHP) during sexual differentiation causes male reproductive tract…”
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Transgenerational Effects of Di (2-Ethylhexyl) Phthalate in the Male CRL:CD(SD) Rat: Added Value of Assessing Multiple Offspring per Litter by Gray, Leon Earl, Barlow, Norman J., Howdeshell, Kembra L., Ostby, Joseph S., Furr, Johnathan R., Gray, Clark L.

“…In the rat, some phthalates alter sexual differentiation at relatively low dosage levels by altering fetal Leydig cell development and hormone synthesis,…”
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Depression and Its Treatment During Pregnancy: Overview and Highlights by Howdeshell, Kembra L., Ornoy, Asher

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Environmental toxins Exposure to bisphenol A advances puberty by vom Saal, Frederick S, Howdeshell, Kembra L, Hotchkiss, Andrew K, Thayer, Kristina A, Vandenbergh, John G

“…Plastics and pesticides are examples of products that contain oestrogenic endocrine-disrupting chemicals, or EEDCs, which can interfere with mammalian…”
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