Search Results - "Howatt, Deborah A."

Hypercholesterolemia Induced by a PCSK9 Gain-of-Function Mutation Augments Angiotensin II–Induced Abdominal Aortic Aneurysms in C57BL/6 Mice—Brief Report by Lu, Hong, Howatt, Deborah A, Balakrishnan, Anju, Graham, Mark J, Mullick, Adam E, Daugherty, Alan

“…OBJECTIVE—Gain-of-function mutations of PCSK9 (proprotein convertase subtilisin/kexin type 9) lead to hypercholesterolemia. This study was to determine whether…”
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High Density Lipoprotein Protects against Polymicrobe-induced Sepsis in Mice by Guo, Ling, Ai, Junting, Zheng, Zhong, Howatt, Deborah A., Daugherty, Alan, Huang, Bin, Li, Xiang-An

“…HDL has been considered to be a protective factor in sepsis; however, most contributing studies were conducted using the endotoxic animal model, and evidence…”
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TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions by Chen, Xiaofeng, Rateri, Debra L, Howatt, Deborah A, Balakrishnan, Anju, Moorleghen, Jessica J, Cassis, Lisa A, Daugherty, Alan

“…AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been…”
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Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice by Daugherty, Alan, Rateri, Debra L, Charo, Israel F, Owens, A Phillip, Howatt, Deborah A, Cassis, Lisa A

“…AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms) through multiple proposed mechanisms, including chemotaxis. Therefore, we…”
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Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis—Brief Report by Ye, Feiming, Wang, Ya, Wu, Congqing, Howatt, Deborah A, Wu, Chia-Hua, Balakrishnan, Anju, Mullick, Adam E, Graham, Mark J, Danser, A.H Jan, Wang, Jian’an, Daugherty, Alan, Lu, Hong S

“…OBJECTIVE—AGT (Angiotensinogen) is the unique precursor of the renin-angiotensin system that is sequentially cleaved by renin and ACE (angiotensin-converting…”
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Chronic environmental circadian disruption increases atherosclerosis and dyslipidemia in female, but not male, ApolipoproteinE -deficient mice by Chalfant, Jeffrey M, Howatt, Deborah A, Johnson, Victoria B, Tannock, Lisa R, Daugherty, Alan, Pendergast, Julie S

“…Shift work chronically disrupts circadian rhythms and increases the risk of developing cardiovascular disease. However, the mechanisms linking shift work and…”
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ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice by Cassis, Lisa A, Gupte, Manisha, Thayer, Sarah, Zhang, Xuan, Charnigo, Richard, Howatt, Deborah A, Rateri, Debra L, Daugherty, Alan

“…Infusion of ANG II in hyperlipidemic mice augments atherosclerosis and causes formation of abdominal aortic aneurysms (AAAs). The purpose of this study was to…”
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Increasing Adipocyte Lipoprotein Lipase Improves Glucose Metabolism in High Fat Diet-induced Obesity by Walton, R. Grace, Zhu, Beibei, Unal, Resat, Spencer, Michael, Sunkara, Manjula, Morris, Andrew J., Charnigo, Richard, Katz, Wendy S., Daugherty, Alan, Howatt, Deborah A., Kern, Philip A., Finlin, Brian S.

“…Lipid accumulation in liver and skeletal muscle contributes to co-morbidities associated with diabetes and obesity. We made a transgenic mouse in which the…”
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Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation by Sawada, Hisashi, Kukida, Masayoshi, Chen, Xiaofeng, Howatt, Deborah A., Moorleghen, Jessica J., Balakrishnan, Anju, Wu, Congqing, Daugherty, Alan, Lu, Hong S.

“…Background:Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE…”
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Endothelial Cell–Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II–Induced Ascending Aortic Aneurysms in LDL Receptor−/− Mice by Rateri, Debra L, Moorleghen, Jessica J, Balakrishnan, Anju, Owens, A Phillip, Howatt, Deborah A, Subramanian, Venkateswaran, Poduri, Aruna, Charnigo, Richard, Cassis, Lisa A, Daugherty, Alan

“…RATIONALE:Human studies and mouse models have provided evidence for angiotensin II (Ang II)–based mechanisms as an underlying cause of aneurysms localized to…”
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Angiotensin-Converting Enzyme 2 Decreases Formation and Severity of Angiotensin II–Induced Abdominal Aortic Aneurysms by Thatcher, Sean E, Zhang, Xuan, Howatt, Deborah A, Yiannikouris, Frederique, Gurley, Susan B, Ennis, Terri, Curci, John A, Daugherty, Alan, Cassis, Lisa A

“…OBJECTIVE—Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (AngII) to form angiotensin-(1–7) (Ang-(1–7)), which generally opposes effects of…”
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Smooth Muscle Cell Deletion of Low-Density Lipoprotein Receptor–Related Protein 1 Augments Angiotensin II–Induced Superior Mesenteric Arterial and Ascending Aortic Aneurysms by Davis, Frank M, Rateri, Debra L, Balakrishnan, Anju, Howatt, Deborah A, Strickland, Dudley K, Muratoglu, Selen C, Haggerty, Christopher M, Fornwalt, Brandon K, Cassis, Lisa A, Daugherty, Alan

“…OBJECTIVE—Low-density lipoprotein receptor–related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to…”
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Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms by Howatt, Deborah A., Dajee, Maya, Xie, Xiaojie, Moorleghen, Jessica, Rateri, Debra L., Balakrishnan, Anju, Cunha, Valdeci Da, Johns, Douglas G., Gutstein, David E., Daugherty, Alan, Lu, Hong

“…Background:This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms…”
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Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis—Brief Report by Chen, Xiaofeng, Howatt, Deborah A, Balakrishnan, Anju, Moorleghen, Jessica J, Wu, Congqing, Cassis, Lisa A, Daugherty, Alan, Lu, Hong

“…OBJECTIVE—Angiotensin-converting enzyme (ACE) is present in many cell types of atherosclerotic lesions. This study determined whether ACE activity in…”
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Adropin: An endocrine link between the biological clock and cholesterol homeostasis by Ghoshal, Sarbani, Stevens, Joseph R, Billon, Cyrielle, Girardet, Clemence, Sitaula, Sadichha, Leon, Arthur S, Rao, D C, Skinner, James S, Rankinen, Tuomo, Bouchard, Claude, Nuñez, Marinelle V, Stanhope, Kimber L, Howatt, Deborah A, Daugherty, Alan, Zhang, Jinsong, Schuelke, Matthew, Weiss, Edward P, Coffey, Alisha R, Bennett, Brian J, Sethupathy, Praveen, Burris, Thomas P, Havel, Peter J, Butler, Andrew A

“…Identify determinants of plasma adropin concentrations, a secreted peptide translated from the Energy Homeostasis Associated (ENHO) gene linked to metabolic…”
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Calpain Inhibition Attenuates Adipose Tissue Inflammation and Fibrosis in Diet-induced Obese Mice by Muniappan, Latha, Javidan, Aida, Jiang, Weihua, Mohammadmoradi, Shayan, Moorleghen, Jessica J., Katz, Wendy S., Balakrishnan, Anju, Howatt, Deborah A., Subramanian, Venkateswaran

“…Adipose tissue macrophages have been proposed as a link between obesity and insulin resistance. However, the mechanisms underlying these processes are not…”
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MyD88 Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation Independent of Signaling Through Toll-Like Receptors 2 and 4 by Owens, A Phillip, Rateri, Debra L, Howatt, Deborah A, Moore, Kathryn J, Tobias, Peter S, Curtiss, Linda K, Lu, Hong, Cassis, Lisa A, Daugherty, Alan

“…OBJECTIVE—The purpose of this study was to determine whether myeloid differentiation factor 88 (MyD88) and its related Toll-like receptors (TLRs) 2 and 4…”
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Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice by Rateri, Debra L, Moorleghen, Jessica J, Knight, Victoria, Balakrishnan, Anju, Howatt, Deborah A, Cassis, Lisa A, Daugherty, Alan

“…Whole body genetic deletion of AT1a receptors in mice uniformly reduces hypercholesterolemia and angiotensin II-(AngII) induced atherosclerosis and abdominal…”
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Deficiency of the NR4A Orphan Nuclear Receptor NOR1 Decreases Monocyte Adhesion and Atherosclerosis by Zhao, Yue, Howatt, Deborah A, Gizard, Florence, Nomiyama, Takashi, Findeisen, Hannes M, Heywood, Elizabeth B, Jones, Karrie L, Conneely, Orla M, Daugherty, Alan, Bruemmer, Dennis

“…RATIONALEThe orphan nuclear receptor NOR1 is a member of the evolutionary highly conserved and ligand-independent NR4A subfamily of the nuclear hormone…”
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Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice by Subramanian, Venkateswaran, Moorleghen, Jessica J, Balakrishnan, Anju, Howatt, Deborah A, Chishti, Athar H, Uchida, Haruhito A

“…Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine…”
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