Search Results - "Howatt, Deborah"

TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions by Chen, Xiaofeng, Rateri, Debra L, Howatt, Deborah A, Balakrishnan, Anju, Moorleghen, Jessica J, Cassis, Lisa A, Daugherty, Alan

“…AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been…”
Get full text

Hypercholesterolemia Induced by a PCSK9 Gain-of-Function Mutation Augments Angiotensin II–Induced Abdominal Aortic Aneurysms in C57BL/6 Mice—Brief Report by Lu, Hong, Howatt, Deborah A, Balakrishnan, Anju, Graham, Mark J, Mullick, Adam E, Daugherty, Alan

“…OBJECTIVE—Gain-of-function mutations of PCSK9 (proprotein convertase subtilisin/kexin type 9) lead to hypercholesterolemia. This study was to determine whether…”
Get full text

High Density Lipoprotein Protects against Polymicrobe-induced Sepsis in Mice by Guo, Ling, Ai, Junting, Zheng, Zhong, Howatt, Deborah A., Daugherty, Alan, Huang, Bin, Li, Xiang-An

“…HDL has been considered to be a protective factor in sepsis; however, most contributing studies were conducted using the endotoxic animal model, and evidence…”
Get full text

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice by Daugherty, Alan, Rateri, Debra L, Charo, Israel F, Owens, A Phillip, Howatt, Deborah A, Cassis, Lisa A

“…AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms) through multiple proposed mechanisms, including chemotaxis. Therefore, we…”
Get more information

Prolonged Infusion of Angiotensin II in apoE−/− Mice Promotes Macrophage Recruitment with Continued Expansion of Abdominal Aortic Aneurysm by Rateri, Debra L, Howatt, Deborah A, Moorleghen, Jessica J, Charnigo, Richard, Cassis, Lisa A, Daugherty, Alan

“…Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due to medial disruption and results in luminal dilation and thrombus…”
Get full text

Circadian disruption with constant light exposure exacerbates atherosclerosis in male ApolipoproteinE-deficient mice by Chalfant, Jeffrey M., Howatt, Deborah A., Tannock, Lisa R., Daugherty, Alan, Pendergast, Julie S.

“…Disruption of the circadian system caused by disordered exposure to light is pervasive in modern society and increases the risk of cardiovascular disease. The…”
Get full text

Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile–Induced Thoracic Aortopathy in Mice—Brief Report by Sawada, Hisashi, Ohno-Urabe, Satoko, Ye, Dien, Franklin, Michael K., Moorleghen, Jessica J., Howatt, Deborah A., Mullick, Adam E., Daugherty, Alan, Lu, Hong S.

Get full text

Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis—Brief Report by Ye, Feiming, Wang, Ya, Wu, Congqing, Howatt, Deborah A, Wu, Chia-Hua, Balakrishnan, Anju, Mullick, Adam E, Graham, Mark J, Danser, A.H Jan, Wang, Jian’an, Daugherty, Alan, Lu, Hong S

“…OBJECTIVE—AGT (Angiotensinogen) is the unique precursor of the renin-angiotensin system that is sequentially cleaved by renin and ACE (angiotensin-converting…”
Get full text

Chronic environmental circadian disruption increases atherosclerosis and dyslipidemia in female, but not male, ApolipoproteinE -deficient mice by Chalfant, Jeffrey M, Howatt, Deborah A, Johnson, Victoria B, Tannock, Lisa R, Daugherty, Alan, Pendergast, Julie S

“…Shift work chronically disrupts circadian rhythms and increases the risk of developing cardiovascular disease. However, the mechanisms linking shift work and…”
Get full text

Increasing Adipocyte Lipoprotein Lipase Improves Glucose Metabolism in High Fat Diet-induced Obesity by Walton, R. Grace, Zhu, Beibei, Unal, Resat, Spencer, Michael, Sunkara, Manjula, Morris, Andrew J., Charnigo, Richard, Katz, Wendy S., Daugherty, Alan, Howatt, Deborah A., Kern, Philip A., Finlin, Brian S.

“…Lipid accumulation in liver and skeletal muscle contributes to co-morbidities associated with diabetes and obesity. We made a transgenic mouse in which the…”
Get full text

Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation by Sawada, Hisashi, Kukida, Masayoshi, Chen, Xiaofeng, Howatt, Deborah A., Moorleghen, Jessica J., Balakrishnan, Anju, Wu, Congqing, Daugherty, Alan, Lu, Hong S.

“…Background:Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE…”
Get full text

Renal Proximal Tubule Cell-Specific Megalin Deletion Does Not Affect Atherosclerosis But Induces Tubulointerstitial Nephritis in Mice Fed a Western Diet by Amioka, Naofumi, Franklin, Michael K., Kukida, Masayoshi, Zhu, Liyuan, Moorleghen, Jessica J., Howatt, Deborah A., Katsumata, Yuriko, Mullick, Adam E., Yanagita, Motoko, Martinez-Irizarry, Michelle M., Sandoval, Ruben M., Dunn, Kenneth W., Sawada, Hisashi, Daugherty, Alan, Lu, Hong S.

“…Pharmacological inhibition of megalin (also known as LRP2 [low-density lipoprotein receptor-related protein-2]) attenuates atherosclerosis in…”
Get full text

Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice by Rateri, Debra L, Moorleghen, Jessica J, Knight, Victoria, Balakrishnan, Anju, Howatt, Deborah A, Cassis, Lisa A, Daugherty, Alan

“…Whole body genetic deletion of AT1a receptors in mice uniformly reduces hypercholesterolemia and angiotensin II-(AngII) induced atherosclerosis and abdominal…”
Get full text

ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice by Cassis, Lisa A, Gupte, Manisha, Thayer, Sarah, Zhang, Xuan, Charnigo, Richard, Howatt, Deborah A, Rateri, Debra L, Daugherty, Alan

“…Infusion of ANG II in hyperlipidemic mice augments atherosclerosis and causes formation of abdominal aortic aneurysms (AAAs). The purpose of this study was to…”
Get more information

Second Heart Field–Derived Cells Contribute to Angiotensin II–Mediated Ascending Aortopathies by Sawada, Hisashi, Katsumata, Yuriko, Higashi, Hideyuki, Zhang, Chen, Li, Yanming, Morgan, Stephanie, Lee, Lang H., Singh, Sasha A., Chen, Jeff Z., Franklin, Michael K., Moorleghen, Jessica J., Howatt, Deborah A., Rateri, Debra L., Shen, Ying H., LeMaire, Scott A., Aikawa, Masanori, Majesky, Mark W., Lu, Hong S., Daugherty, Alan

“…The ascending aorta is a common location for aneurysm and dissection. This aortic region is populated by a mosaic of medial and adventitial cells that are…”
Get full text

Lysyl Oxidase Inhibition Ablates Sexual Dimorphism of Abdominal Aortic Aneurysm Formation in Mice by Okuyama, Michihiro, Jiang, Weihua, Javidan, Aida, Chen, Jeff Zheying, Howatt, Deborah A., Yang, Lihua, Hamaguchi, Mika, Yasugi, Takumi, Aono, Jun, Vazquez-Padron, Roberto Irenardo, Subramanian, Venkateswaran

Get full text

β-Aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice by Franklin, Michael K, Sawada, Hisashi, Ito, Sohei, Howatt, Deborah A, Amioka, Naofumi, Liang, Ching-Ling, Zhang, Nancy, Graf, David B, Moorleghen, Jessica J, Katsumata, Yuriko, Lu, Hong S, Daugherty, Alan

“…β-aminopropionitrile (BAPN) is a pharmacological inhibitor of LOX (lysyl oxidase) and LOXLs (LOX-like proteins). Administration of BAPN promotes aortopathies,…”
Get full text

PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism by Daugherty, Alan, Rateri, Debra L, Howatt, Deborah A, Charnigo, Richard, Cassis, Lisa A

“…AT2 receptors have an unclear function on development of abdominal aortic aneurysms (AAAs), although a pharmacological approach using the AT2 receptor…”
Get full text

Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice by Xie, Xiaojie, Lu, Hong, Moorleghen, Jessica J, Howatt, Deborah A, Rateri, Debra L, Cassis, Lisa A, Daugherty, Alan

“…There is no proven medical approach to attenuating expansion and rupture of abdominal aortic aneurysms (AAAs). One approach that is currently being…”
Get full text

Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice by Subramanian, Venkateswaran, Moorleghen, Jessica J, Balakrishnan, Anju, Howatt, Deborah A, Chishti, Athar H, Uchida, Haruhito A

“…Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine…”
Get full text