Search Results - "Howarth, Kimberley M"

Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24 by Jones, Angela M, Howarth, Kimberley M, Martin, Lynn, Gorman, Maggie, Mihai, Radu, Moss, Laura, Auton, Adam, Lemon, Catherine, Mehanna, Hisham, Mohan, Hosahalli, Clarke, Susan E M, Wadsley, Jonathan, Macias, Elena, Coatesworth, Andrew, Beasley, Matthew, Roques, Tom, Martin, Craig, Ryan, Paul, Gerrard, Georgina, Power, Danielle, Bremmer, Caroline, Tomlinson, Ian, Carvajal-Carmona, Luis G

“…Five single nucleotide polymorphisms (SNPs) associated with thyroid cancer (TC) risk have been reported: rs2910164 (5q24); rs6983267 (8q24); rs965513 and…”
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Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice by SIEBER, Oliver M, HOWARTH, Kimberley M, SILVER, Andrew, HANJING YANG, MILLER, Jeffrey H, ILYAS, Mohammad, TOMLINSON, Ian P. M, THIRLWELL, Christina, ROWAN, Andrew, MANDIR, Nikki, GOODLAD, Robert A, GILKAR, Ashfaq, SPENCER-DENE, Bradley, STAMP, Gordon, JOHNSON, Victoria

“…Monoallelic APC and biallelic MYH (homolog of Escherichia coli mutY) germ-line mutations are independently associated with a strong predisposition to…”
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Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13 by Spain, Sarah L., Carvajal-Carmona, Luis G., Howarth, Kimberley M., Jones, Angela M., Su, Zhan, Cazier, Jean-Baptiste, Williams, Jennet, Aaltonen, Lauri A., Pharoah, Paul, Kerr, David J., Cheadle, Jeremy, Li, Li, Casey, Graham, Vodicka, Pavel, Sieber, Oliver, Lipton, Lara, Gibbs, Peter, Martin, Nicholas G., Montgomery, Grant W., Young, Joanne, Baird, Paul N., Morreau, Hans, van Wezel, Tom, Ruiz-Ponte, Clara, Fernandez-Rozadilla, Ceres, Carracedo, Angel, Castells, Antoni, Castellvi-Bel, Sergi, Dunlop, Malcolm, Houlston, Richard S., Tomlinson, Ian P.M.

“…In genome-wide association studies (GWASs) of colorectal cancer, we have identified two genomic regions in which pairs of tagging-single nucleotide…”
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Homozygous PMS2 Deletion Causes a Severe Colorectal Cancer and Multiple Adenoma Phenotype Without Extraintestinal Cancer by Will, Olivia, Carvajal-Carmona, Luis G, Gorman, Patricia, Howarth, Kimberley M, Jones, Angela M, Polanco-Echeverry, Guadalupe M, Chinaleong, Jo-Anne, Günther, Thomas, Silver, Andrew, Clark, Susan K, Tomlinson, Ian

“…Background & Aims: We report a patient of Indian descent with parental consanguinity, who developed 10 carcinomas and 35 adenomatous polyps at age 23 and…”
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Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas by Palles, Claire, Cazier, Jean-Baptiste, Howarth, Kimberley M, Domingo, Enric, Jones, Angela M, Broderick, Peter, Kemp, Zoe, Spain, Sarah L, Guarino, Estrella, Salguero, Israel, Sherborne, Amy, Chubb, Daniel, Carvajal-Carmona, Luis G, Ma, Yusanne, Kaur, Kulvinder, Dobbins, Sara, Barclay, Ella, Gorman, Maggie, Martin, Lynn, Kovac, Michal B, Humphray, Sean, Thomas, Huw J W, Maher, Eamonn, Evans, Gareth, Lucassen, Anneke, Cummings, Carole, Stevens, Margaret, Walker, Lisa, Halliday, Dorothy, Armstrong, Ruth, Paterson, Joan, Hodgson, Shirley, Homfray, Tessa, Side, Lucy, Izatt, Louise, Donaldson, Alan, Tomkins, Susan, Morrison, Patrick, Goodman, Selina, Brewer, Carole, Henderson, Alex, Davidson, Rosemarie, Murday, Victoria, Cook, Jaqueline, Haites, Neva, Bishop, Timothy, Sheridan, Eamonn, Green, Andrew, Marks, Christopher, Carpenter, Sue, et. al

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DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer by Church, David N., Briggs, Sarah E.W., Palles, Claire, Domingo, Enric, Kearsey, Stephen J., Grimes, Jonathon M., Gorman, Maggie, Martin, Lynn, Howarth, Kimberley M., Hodgson, Shirley V., Kaur, Kulvinder, Taylor, Jenny, Tomlinson, Ian P.M.

“…Accurate duplication of DNA prior to cell division is essential to suppress mutagenesis and tumour development. The high fidelity of eukaryotic DNA replication…”
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DNA polymerase epsilon and [delta] exonuclease domain mutations in endometrial cancer by Church, David N, Briggs, Sarah EW, Palles, Claire, Domingo, Enric, Kearsey, Stephen J, Grimes, Jonathon M, Gorman, Maggie, Martin, Lynn, Howarth, Kimberley M, Hodgson, Shirley V, Kaur, Kulvinder, Taylor, Jenny, Tomlinson, Ian PM

“…Accurate duplication of DNA prior to cell division is essential to suppress mutagenesis and tumour development. The high fidelity of eukaryotic DNA replication…”
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Erratum: Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas by Palles, Claire, Cazier, Jean-Baptiste, Howarth, Kimberley M, Domingo, Enric, Jones, Angela M, Broderick, Peter, Kemp, Zoe, Spain, Sarah L, Guarino, Estrella, Salguero, Israel, Sherborne, Amy, Chubb, Daniel, Carvajal-Carmona, Luis G, Ma, Yusanne, Kaur, Kulvinder, Dobbins, Sara, Barclay, Ella, Gorman, Maggie, Martin, Lynn, Kovac, Michal B, Humphray, Sean, Lucassen, Anneke, Holmes, Christopher C, Bentley, David, Donnelly, Peter, Taylor, Jenny, Petridis, Christos, Roylance, Rebecca, Sawyer, Elinor J, Kerr, David J, Clark, Susan, Grimes, Jonathan, Kearsey, Stephen E, Thomas, Huw J W, McVean, Gilean, Houlston, Richard S, Tomlinson, Ian

“…Nat. Genet. 45, 136–144 (2013); published online 23 December 2012; corrected after print 8 May 2013 In the version of this article initially published, the…”
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Germline mutations in the proof-reading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas by Palles, Claire, Cazier, Jean-Baptiste, Howarth, Kimberley M, Domingo, Enric, Jones, Angela M., Broderick, Peter, Kemp, Zoe, Spain, Sarah L, Almeida, Estrella Guarino, Salguero, Israel, Sherborne, Amy, Chubb, Daniel, Carvajal-Carmona, Luis G, Ma, Yusanne, Kaur, Kulvinder, Dobbins, Sara, Barclay, Ella, Gorman, Maggie, Martin, Lynn, Kovac, Michal B, Humphray, Sean, Lucassen, Anneke, Holmes, Christopher, Bentley, David, Donnelly, Peter, Taylor, Jenny, Petridis, Christos, Roylance, Rebecca, Sawyer, Elinor J, Kerr, David J., Clark, Susan, Grimes, Jonathan, Kearsey, Stephen E, Thomas, Huw JW, McVean, Gilean, Houlston, Richard S, Tomlinson, Ian

“…Many individuals with multiple or large colorectal adenomas, or early-onset colorectal cancer (CRC), have no detectable germline mutations in the known cancer…”
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DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer by Church, David N, Briggs, Sarah E W, Palles, Claire, Domingo, Enric, Kearsey, Stephen J, Grimes, Jonathon M, Gorman, Maggie, Martin, Lynn, Howarth, Kimberley M, Hodgson, Shirley V, Kaur, Kulvinder, Taylor, Jenny, Tomlinson, Ian P M

“…Accurate duplication of DNA prior to cell division is essential to suppress mutagenesis and tumour development. The high fidelity of eukaryotic DNA replication…”
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