Search Results - "Howarth, Deanna L."

Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish by Howarth, Deanna L, Lindtner, Claudia, Vacaru, Ana M, Sachidanandam, Ravi, Tsedensodnom, Orkhontuya, Vasilkova, Taisa, Buettner, Christoph, Sadler, Kirsten C

“…Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of…”
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Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease by Tsedensodnom, Orkhontuya, Vacaru, Ana M, Howarth, Deanna L, Yin, Chunyue, Sadler, Kirsten C

“…Secretory pathway dysfunction and lipid accumulation (steatosis) are the two most common responses of hepatocytes to ethanol exposure and are major factors in…”
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Alcohol Disrupts Endoplasmic Reticulum Function and Protein Secretion in Hepatocytes by Howarth, Deanna L., Vacaru, Ana M., Tsedensodnom, Orkhontuya, Mormone, Elisabetta, Nieto, Natalia, Costantini, Lindsey M., Snapp, Erik L., Sadler, Kirsten C.

“…Background:  Many alcoholic patients have serum protein deficiency that contributes to their systemic problems. The unfolded protein response (UPR) is induced…”
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Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae by Howarth, Deanna L, Yin, Chunyue, Yeh, Karen, Sadler, Kirsten C

“…Fatty liver disease in humans can progress from steatosis to hepatocellular injury, fibrosis, cirrhosis, and liver failure. We developed a series of…”
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Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish by Vacaru, Ana M, Di Narzo, Antonio Fabio, Howarth, Deanna L, Tsedensodnom, Orkhontuya, Imrie, Dru, Cinaroglu, Ayca, Amin, Salma, Hao, Ke, Sadler, Kirsten C

“…The unfolded protein response (UPR) is a complex network of sensors and target genes that ensure efficient folding of secretory proteins in the endoplasmic…”
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Paralogous Vitamin D Receptors in Teleosts: Transition of Nuclear Receptor Function by Howarth, Deanna L, Law, Sheran H. W, Barnes, Benjamin, Hall, Julie M, Hinton, David E, Moore, Linda, Maglich, Jodi M, Moore, John T, Kullman, Seth W

“…The availability of multiple teleost (bony fish) genomes is providing unprecedented opportunities to understand the diversity and function of gene duplication…”
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Drinks Like a Fish: Using Zebrafish to Understand Alcoholic Liver Disease by Howarth, Deanna L., Passeri, Mike, Sadler, Kirsten C.

“…Steatosis is the most common consequence of acute alcohol abuse, such as occurs during a drinking binge. Acute alcohol induced steatosis may predispose to more…”
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Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka ( Oryzias latipes) by Howarth, Deanna L., Law, Sheran H.W., Law, J. McHugh, Mondon, J.A., Kullman, Seth W., Hinton, David E.

“…The small freshwater teleost, medaka ( Oryzias latipes), has a history of usage in studies of chronic toxicity of liver and biliary system. Recent progress…”
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Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in alcoholic liver disease by Tsedensodnom, Orkhontuya, Vacaru, Ana M., Howarth, Deanna L., Yin, Chunyue, Sadler, Kirsten C.

“…Summary Secretory pathway dysfunction and lipid accumulation (steatosis) are the two most common responses of hepatocytes exposed to ethanol and are major…”
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Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro by Howarth, Deanna L., Hagey, Lee R., Law, Sheran H.W., Ai, Ni, Krasowski, Matthew D., Ekins, Sean, Moore, John T., Kollitz, Erin M., Hinton, David E., Kullman, Seth W.

“…The nuclear receptor farnesoid X receptor alpha (FXRα, NR1H4) is activated by bile acids in multiple species including mouse, rat, and human and in this study…”
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Protective Response of the Ah Receptor to ANIT-Induced Biliary Epithelial Cell Toxicity in See-Through Medaka by Volz, David C., Kullman, Seth W., Howarth, Deanna L., Hardman, Ron C., Hinton, David E.

“…The adaptive role of the aryl hydrocarbon receptor (Ah receptor or AHR) in protecting against disease-related conditions remains unclear in nonmammalian…”
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Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish: e1004335 by Howarth, Deanna L, Lindtner, Claudia, Vacaru, Ana M, Sachidanandam, Ravi, Tsedensodnom, Orkhontuya, Vasilkova, Taisa, Buettner, Christoph, Sadler, Kirsten C

“…Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of…”
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Drinks Like a Fish: Using Zebrafish to Understand Alcoholic Liver Disease: DRINKS LIKE A FISH by Howarth, Deanna L., Passeri, Mike, Sadler, Kirsten C.

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