Search Results - "Howard, Sean"

Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes by Ranjha, Lepakshi, Howard, Sean M., Cejka, Petr

“…DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and chemicals or result from faulty DNA metabolic processes. DNA breaks can also…”
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DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining by Howard, Sean M, Yanez, Diana A, Stark, Jeremy M

“…Alternative end joining (Alt-EJ) chromosomal break repair involves bypassing classical non-homologous end joining (c-NHEJ), and such repair causes mutations…”
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CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection by Ceppi, Ilaria, Howard, Sean M., Kasaciunaite, Kristina, Pinto, Cosimo, Anand, Roopesh, Seidel, Ralf, Cejka, Petr

“…To repair a DNA double-strand break by homologous recombination, 5′-terminated DNA strands must first be resected to reveal 3′- overhangs. This process is…”
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Evidence for dispersing 1D Majorana channels in an iron-based superconductor by Wang, Zhenyu, Rodriguez, Jorge Olivares, Jiao, Lin, Howard, Sean, Graham, Martin, Gu, G D, Hughes, Taylor L, Morr, Dirk K, Madhavan, Vidya

“…The possible realization of Majorana fermions as quasiparticle excitations in condensed-matter physics has created much excitement. Most studies have focused…”
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Phosphorylated CtIP bridges DNA to promote annealing of broken ends by Öz, Robin, Howard, Sean M., Sharma, Rajhans, Törnkvist, Hanna, Ceppi, Ilaria, KK, Sriram, Kristiansson, Erik, Cejka, Petr, Westerlund, Fredrik

“…The early steps of DNA double-strand break (DSB) repair in human cells involve the MRE11-RAD50-NBS1 (MRN) complex and its cofactor, phosphorylated CtIP. The…”
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Evidence for one-dimensional chiral edge states in a magnetic Weyl semimetal Co3Sn2S2 by Howard, Sean, Jiao, Lin, Wang, Zhenyu, Morali, Noam, Batabyal, Rajib, Kumar-Nag, Pranab, Avraham, Nurit, Beidenkopf, Haim, Vir, Praveen, Liu, Enke, Shekhar, Chandra, Felser, Claudia, Hughes, Taylor, Madhavan, Vidya

“…The physical realization of Chern insulators is of fundamental and practical interest, as they are predicted to host the quantum anomalous Hall (QAH) effect…”
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Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination by Onyango, David O, Howard, Sean M, Neherin, Kashfia, Yanez, Diana A, Stark, Jeremy M

“…We examined the influence of the tetratricopeptide repeat factor XAB2 on chromosomal break repair, and found that XAB2 promotes end resection that generates…”
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Nuclear actin structure regulates chromatin accessibility by Sen, Buer, Xie, Zhihui, Thomas, Michelle D., Pattenden, Samantha G., Howard, Sean, McGrath, Cody, Styner, Maya, Uzer, Gunes, Furey, Terrence S., Rubin, Janet

“…Polymerized β-actin may provide a structural basis for chromatin accessibility and actin transport into the nucleus can guide mesenchymal stem cell (MSC)…”
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Biological maturity-associated variance in peak power output and momentum in academy rugby union players by Howard, Sean M. A., Cumming, Sean P., Atkinson, Mark, Malina, Robert M.

“…The study aimed to evaluate the mediating effect of biological maturation on anthropometrical measurements, performance indicators and subsequent selection in…”
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Confronting the contradictions between Western and Indigenous science: A critical perspective on two-eyed seeing by Broadhead, Lee-Anne, Howard, Sean

“…In the mid-2000s, the term Two-Eyed Seeing was introduced by Mi'kmaw Elder Albert Marshall to suggest the complementarity of Western and Indigenous sciences…”
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Target optimization for the photonuclear production of radioisotopes by Howard, Sean, Starovoitova, Valeriia N.

“…In this paper we discuss the optimum shape of a target for photonuclear production of radioisotopes using an electron linear accelerator. Different target…”
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BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment by D’Alessandro, Giuseppina, Whelan, Donna Rose, Howard, Sean Michael, Vitelli, Valerio, Renaudin, Xavier, Adamowicz, Marek, Iannelli, Fabio, Jones-Weinert, Corey Winston, Lee, MiYoung, Matti, Valentina, Lee, Wei Ting C., Morten, Michael John, Venkitaraman, Ashok Raraakrishnan, Cejka, Petr, Rothenberg, Eli, d’Adda di Fagagna, Fabrizio

“…DNA double-strand breaks (DSBs) are toxic DNA lesions, which, if not properly repaired, may lead to genomic instability, cell death and senescence…”
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NBS1 promotes the endonuclease activity of the MRE11‐RAD50 complex by sensing CtIP phosphorylation by Anand, Roopesh, Jasrotia, Arti, Bundschuh, Diana, Howard, Sean Michael, Ranjha, Lepakshi, Stucki, Manuel, Cejka, Petr

“…DNA end resection initiates DNA double‐strand break repair by homologous recombination. MRE11‐RAD50‐NBS1 and phosphorylated CtIP perform the first resection…”
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Data‐Driven and Cell‐Specific Determination of Nuclei‐Associated Actin Structure by Nikitina, Nina, Bursa, Nurbanu, Goelzer, Matthew, Goldfeldt, Madison, Crandall, Chase, Howard, Sean, Rubin, Janet, Zavala, Anamaria, Satici, Aykut, Uzer, Gunes

“…Quantitative volumetric assessment of filamentous actin (F‐actin) fibers remains challenging due to their interconnected nature, leading researchers to utilize…”
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Increased deformations are dispensable for encapsulated cell mechanoresponse in engineered bone analogs mimicking aging bone marrow by Regner, Alexander M., DeLeon, Maximilien, Gibbons, Kalin D., Howard, Sean, Nesbitt, Derek Q., Darghiasi, Seyedeh F., Zavala, Anamaria G., Lujan, Trevor J., Fitzpatrick, Clare K., Farach-Carson, Mary C., Wu, Danielle, Uzer, Gunes

“…Aged individuals and astronauts experience bone loss despite rigorous physical activity. Bone mechanoresponse is in-part regulated by mesenchymal stem cells…”
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Chiral superconductivity in heavy-fermion metal UTe2 by Jiao, Lin, Howard, Sean, Ran, Sheng, Wang, Zhenyu, Rodriguez, Jorge Olivares, Sigrist, Manfred, Wang, Ziqiang, Butch, Nicholas P., Madhavan, Vidya

“…Spin-triplet superconductors are condensates of electron pairs with spin 1 and an odd-parity wavefunction 1 . An interesting manifestation of triplet pairing…”
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Conformers, Energetics, and Basicity of 2,2‘-Bipyridine by Howard, Sean T.

“…The proton affinities of the cis and trans conformers of 2,2‘-bipyridine have been determined at the MP2/6−31G**//HF/6−31G** level of theory. The neutral…”
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Direct-spun CNT textiles for high-performance electromagnetic interference shielding in an ultra-wide bandwidth by Issman, Liron, Alper, Matan, Howard, Sean, Karch, Christian, Yeshurun, Shuki, Pick, Martin, Boies, Adam

“…Electromagnetic interference (EMI) generated by electronic devices is disruptive to surrounding electronic components and deemed harmful to human beings. As…”
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Osterix‐driven LINC complex disruption in vivo diminishes osteogenesis at 8 weeks but not at 15 weeks by Birks, Scott, Howard, Sean, O'Rourke, Caroline, Thompson, William R., Lau, Anthony, Uzer, Gunes

“…The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex is a crucial connective component between the nuclear envelope and the cytoskeleton involving…”
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The internal region of CtIP negatively regulates DNA end resection by Howard, Sean Michael, Ceppi, Ilaria, Anand, Roopesh, Geiger, Roger, Cejka, Petr

“…DNA double-strand breaks are repaired by end-joining or homologous recombination. A key-committing step of recombination is DNA end resection. In resection,…”
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