Search Results - "Howard, Scott C."

Preventing and Managing Toxicities of High‐Dose Methotrexate by Howard, Scott C., McCormick, John, Pui, Ching‐Hon, Buddington, Randall K., Harvey, R. Donald

“…High‐dose methotrexate (HDMTX), defined as a dose higher than 500 mg/m2, is used to treat a range of adult and childhood cancers. Although HDMTX is safely…”
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Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers by Dunnenberger, Henry M, Crews, Kristine R, Hoffman, James M, Caudle, Kelly E, Broeckel, Ulrich, Howard, Scott C, Hunkler, Robert J, Klein, Teri E, Evans, William E, Relling, Mary V

“…Although the field of pharmacogenetics has existed for decades, practioners have been slow to implement pharmacogenetic testing in clinical care. Numerous…”
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Costs, affordability, and feasibility of an essential package of cancer control interventions in low-income and middle-income countries: key messages from Disease Control Priorities , 3rd edition by Gelband, Hellen, MHS, Sankaranarayanan, Rengaswamy, MD, Gauvreau, Cindy L, PhD, Horton, Susan, Prof, Anderson, Benjamin O, MD, Bray, Freddie, DPhil, Cleary, James, MD, Dare, Anna J, PhD, Denny, Lynette, MD, Gospodarowicz, Mary K, MD, Gupta, Sumit, MD, Howard, Scott C, Prof, Jaffray, David A, PhD, Knaul, Felicia, PhD, Levin, Carol, PhD, Rabeneck, Linda, MD, Rajaraman, Preetha, PhD, Sullivan, Terrence, PhD, Trimble, Edward L, MD, Jha, Prabhat, Prof

“…Summary Investments in cancer control—prevention, detection, diagnosis, surgery, other treatment, and palliative care—are increasingly needed in low-income and…”
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Current management and challenges of malignant disease in the CNS in paediatric leukaemia by Pui, Ching-Hon, Prof, Howard, Scott C, MD

“…Summary With 5-year event-free survival of 80% now commonplace for paediatric acute lymphoblastic leukaemia (ALL), and 50% for paediatric acute myeloid…”
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Paediatric cancer in low-income and middle-income countries by Magrath, Ian, Prof, Steliarova-Foucher, Eva, PhD, Epelman, Sidnei, MD, Ribeiro, Raul C, Prof, Harif, Mhamed, Prof, Li, Chi-Kong, Prof, Kebudi, Rejin, Prof, Macfarlane, Scott D, MBChB, Howard, Scott C, Prof

“…Summary Patterns of cancer incidence across the world have undergone substantial changes as a result of industrialisation and economic development. However,…”
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Pediatric oncology as the next global child health priority: the need for national childhood cancer strategies in low- and middle-income countries by Gupta, Sumit, Rivera-Luna, Roberto, Ribeiro, Raul C, Howard, Scott C

“…Dr. Sumit Gupta and colleagues discuss the need for national cancer strategies for children in low- and middle-income countries and suggest how such strategies…”
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Methotrexate-Induced Neurotoxicity and Leukoencephalopathy in Childhood Acute Lymphoblastic Leukemia by BHOJWANI, Deepa, SABIN, Noah D, HOWARD, Scott C, RIBEIRO, Raul C, CHENG CHENG, REDDICK, Wilburn E, JEHA, Sima, SANDLUND, John T, EVANS, William E, PUI, Ching-Hon, RELLING, Mary V, DEQING PEI, YANG, Jun J, KHAN, Raja B, PANETTA, John C, KRULL, Kevin R, INABA, Hiroto, RUBNITZ, Jeffrey E, METZGER, Monika L

“…Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and…”
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PG4KDS: A model for the clinical implementation of pre-emptive pharmacogenetics by Hoffman, James M., Haidar, Cyrine E., Wilkinson, Mark R., Crews, Kristine R., Baker, Donald K., Kornegay, Nancy M., Yang, Wenjian, Pui, Ching-Hon, Reiss, Ulrike M., Gaur, Aditya H., Howard, Scott C., Evans, William E., Broeckel, Ulrich, Relling, Mary V.

“…Pharmacogenetics is frequently cited as an area for initial focus of the clinical implementation of genomics. Through the PG4KDS protocol, St. Jude Children's…”
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Management of occlusion and thrombosis associated with long-term indwelling central venous catheters by Baskin, Jacquelyn L, MD, Pui, Ching-Hon, Prof, Reiss, Ulrike, MD, Wilimas, Judith A, MD, Metzger, Monika L, MD, Ribeiro, Raul C, MD, Howard, Scott C, Dr

“…Summary Long-term central venous catheters (CVCs) are important instruments in the care of patients with chronic illnesses, but catheter occlusions and…”
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Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation by Pui, Ching-Hon, Campana, Dario, Pei, Deqing, Bowman, W. Paul, Sandlund, John T, Kaste, Sue C, Ribeiro, Raul C, Rubnitz, Jeffrey E, Raimondi, Susana C, Onciu, Mihaela, Coustan-Smith, Elaine, Kun, Larry E, Jeha, Sima, Cheng, Cheng, Howard, Scott C, Simmons, Vickey, Bayles, Amy, Metzger, Monika L, Boyett, James M, Leung, Wing, Handgretinger, Rupert, Downing, James R, Evans, William E, Relling, Mary V

“…This large trial of acute lymphoblastic leukemia in children aimed to determine whether intensive systemic and intrathecal chemotherapy could obviate the need…”
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New policies to address the global burden of childhood cancers by Sullivan, Richard, Prof, Kowalczyk, Jerzy R, Prof, Agarwal, Bharat, MD, Ladenstein, Ruth, Prof, Fitzgerald, Edel, PhD, Barr, Ronald, Prof, Steliarova-Foucher, Eva, PhD, Magrath, Ian, Prof, Howard, Scott C, MD, Kruger, Mariana, Prof, Valsecchi, Maria Grazia, MD, Biondi, Andrea, Prof, Grundy, Paul, MD, Smith, Malcolm A, MD, Adamson, Peter, MD, Vassal, Gilles, Prof, Pritchard-Jones, Kathy, Prof

“…Summary Childhood cancer is a major global health issue. Every year, almost 100 000 children die from cancer before the age of 15 years, more than 90% of them…”
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Paediatric cancer stage in population-based cancer registries: the Toronto consensus principles and guidelines by Gupta, Sumit, Dr, Aitken, Joanne F, PhD, Bartels, Ute, MD, Brierley, James, MBBS, Dolendo, Mae, MD, Friedrich, Paola, MD, Fuentes-Alabi, Soad, MD, Garrido, Claudia P, MD, Gatta, Gemma, MD, Gospodarowicz, Mary, MD, Gross, Thomas, PhD, Howard, Scott C, MD, Molyneux, Elizabeth, PRCPCH, Moreno, Florencia, MD, Pole, Jason D, PhD, Pritchard-Jones, Kathy, PhD, Ramirez, Oscar, MD, Ries, Lynn A G, MS, Rodriguez-Galindo, Carlos, MD, Shin, Hee Young, PhD, Steliarova-Foucher, Eva, PhD, Sung, Lillian, PhD, Supriyadi, Eddy, PhD, Swaminathan, Rajaraman, PhD, Torode, Julie, PhD, Vora, Tushar, MD, Kutluk, Tezer, PhD, Frazier, A Lindsay, MD

“…Summary Population-based cancer registries generate estimates of incidence and survival that are essential for cancer surveillance, research, and control…”
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Baseline status of paediatric oncology care in ten low-income or mid-income countries receiving My Child Matters support: a descriptive study by Ribeiro, Raul C, Prof, Steliarova-Foucher, Eva, PhD, Magrath, Ian, Prof, Lemerle, Jean, Prof, Eden, Tim, Prof, Forget, Caty, MSc, Mortara, Isabel, MBA, Tabah-Fisch, Isabelle, MD, Divino, Jose Julio, MPH, Miklavec, Thomas, MBA, Howard, Scott C, MD, Cavalli, Franco, Prof

“…Summary Background Childhood-cancer survival is dismal in most low-income countries, but initiatives for treating paediatric cancer have substantially improved…”
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Long-Term Efficacy of Methylphenidate in Enhancing Attention Regulation, Social Skills, and Academic Abilities of Childhood Cancer Survivors by CONKLIN, Heather M, REDDICK, Wilburn E, XIAOPING XIONG, KHAN, Raja B, ASHFORD, Jason, OGG, Susan, HOWARD, Scott C, MORRIS, E. Brannon, BROWN, Ronald, BONNER, Melanie, CHRISTENSEN, Robbin, SHENGJIE WU

“…Methylphenidate (MPH) ameliorates attention problems experienced by some cancer survivors in the short term, but its long-term efficacy is unproven. This study…”
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Treatment Outcomes in Black and White Children With Cancer: Results From the SEER Database and St Jude Children's Research Hospital, 1992 Through 2007 by PUI, Ching-Hon, DEQING PEI, JEHA, Sima, HUDSON, Melissa M, KUN, Larry E, MERCHANT, Thomas E, KOCAK, Mehmet, BRONISCER, Alberto, METZGER, Monika L, DOWNING, James R, WING LEUNG, EVANS, William E, PAPPO, Alberto S, GAJJAR, Amar, HOWARD, Scott C, CHENG CHENG, SANDLUND, John T, FURMAN, Wayne L, RIBEIRO, Raul C, SPUNT, Sheri L, RUBNITZ, Jeffrey E

“…Treatment outcome for black patients with cancer has been significantly worse than for their white counterparts. We determined whether recent improved…”
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Improved Prognosis for Older Adolescents With Acute Lymphoblastic Leukemia by PUI, Ching-Hon, DEQING PEI, CHENG CHENG, METZGER, Monika L, BHOJWANI, Deepa, INABA, Hiroto, RAIMONDI, Susana C, ONCIU, Mihaela, HOWARD, Scott C, LEUNG, Wing, DOWNING, James R, EVANS, William E, CAMPANA, Dario, RELLING, Mary V, BOWMAN, W. Paul, SANDLUND, John T, KASTE, Sue C, RIBEIRO, Raul C, RUBNITZ, Jeffrey E, COUSTAN-SMITH, Elaine, JEHA, Sima

“…The prognosis for older adolescents and young adults with acute lymphoblastic leukemia (ALL) has been historically much worse than that for younger patients…”
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Impact of tyrosine kinase inhibitors on minimal residual disease and outcome in childhood Philadelphia chromosome‐positive acute lymphoblastic leukemia by Jeha, Sima, Coustan‐Smith, Elaine, Pei, Deqing, Sandlund, John T., Rubnitz, Jeffrey E., Howard, Scott C., Inaba, Hiroto, Bhojwani, Deepa, Metzger, Monika L., Cheng, Cheng, Choi, John K., Jacobsen, Jeffrey, Shurtleff, Sheila A., Raimondi, Susana, Ribeiro, Raul C., Pui, Ching‐Hon, Campana, Dario

“…BACKGROUND Breakpoint cluster region‐Abelson murine leukemia viral oncogene homolog 1 (BCR‐ABL1) tyrosine kinase inhibitors (TKIs) improve the outcome of…”
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Reported availability and gaps of pediatric palliative care in low- and middle-income countries: a systematic review of published data by Caruso Brown, Amy E, Howard, Scott C, Baker, Justin N, Ribeiro, Raul C, Lam, Catherine G

“…The majority of young people in need of palliative care live in low- and middle-income countries, where curative treatment is less available. We systematically…”
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Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia by Kawedia, Jitesh D., Liu, Chengcheng, Pei, Deqing, Cheng, Cheng, Fernandez, Christian A., Howard, Scott C., Campana, Dario, Panetta, John C., Bowman, W. Paul, Evans, William E., Pui, Ching-Hon, Relling, Mary V.

“…We have previously hypothesized that higher systemic exposure to asparaginase may cause increased exposure to dexamethasone, both critical chemotherapeutic…”
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Multiple Asparaginase Infusions Cause Increasingly Severe Acute Hyperammonemia by Buddington, Randal K, Buddington, Karyl K, Howard, Scott C

“…Adverse reactions during and shortly after infusing asparaginase for the treatment of acute lymphoblastic leukemia can increase in severity with later doses,…”
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