Search Results - "Howard, Maureen C"

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development by Burns, Jennifer M, Summers, Bretton C, Wang, Yu, Melikian, Anita, Berahovich, Rob, Miao, Zhenhua, Penfold, Mark E T, Sunshine, Mary Jean, Littman, Dan R, Kuo, Calvin J, Wei, Kevin, McMaster, Brian E, Wright, Kim, Howard, Maureen C, Schall, Thomas J

“…The chemokine stromal cell-derived factor (SDF-1; also known as chemokine ligand 12 [CXCL12]) regulates many essential biological processes, including cardiac…”
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CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature by Miao, Zhenhua, Luker, Kathryn E, Summers, Bretton C, Berahovich, Rob, Bhojani, Mahaveer S, Rehemtulla, Alnawaz, Kleer, Celina G, Essner, Jeffrey J, Nasevicius, Aidas, Luker, Gary D, Howard, Maureen C, Schall, Thomas J

“…Chemokines and chemokine receptors have been posited to have important roles in several common malignancies, including breast and lung cancer. Here, we…”
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Engineered CAR-T cells targeting TAG-72 and CD47 in ovarian cancer by Shu, Runzhe, Evtimov, Vera J., Hammett, Maree V., Nguyen, Nhu-Y N., Zhuang, Junli, Hudson, Peter J., Howard, Maureen C., Pupovac, Aleta, Trounson, Alan O., Boyd, Richard L.

“…Chimeric antigen receptor (CAR) T cells have revolutionized blood cancer immunotherapy; however, their efficacy against solid tumors has been limited. A common…”
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Proteolytic Activation of Alternative CCR1 Ligands in Inflammation by Berahovich, Robert D, Miao, Zhenhua, Wang, Yu, Premack, Brett, Howard, Maureen C, Schall, Thomas J

“…Although chemokines CCL3/MIP-1alpha and CCL5/RANTES are considered to be primary CCR1 ligands in inflammatory responses, alternative CCR1 ligands have also…”
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Arrest of B Lymphocyte Terminal Differentiation by CD40 Signaling: Mechanism for Lack of Antibody-Secreting Cells in Germinal Centers by Randall, Troy D, Heath, Andrew W, Santos-Argumedo, Leopoldo, Howard, Maureen C, Weissman, Irving L, Lund, Frances E

“…Despite extensive research, the role of CD40 signaling in B cell terminal differentiation remains controversial. Here we show that CD40 engagement arrests B…”
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Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3) by Grimaldi, J. Christopher, Yu, Nai‐Xuan, Grunig, Gabrielle, Seymour, Brian W. P., Cottrez, Françoise, Robinson, Douglas S., Hosken, Nancy, Ferlin, Walter G., Wu, Xiaoyan, Soto, Hortensia, O'Garra, Anne, Howard, Maureen C., Coffman, Robert L.

“…We have generated rat monoclonal antibodies specific for the mouse eotaxin receptor, C‐C chemokine receptor 3 (CCR3). Several anti‐CCR3 mAbs proved to be…”
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CD38 Signaling in B Lymphocytes Is Controlled by Its Ectodomain but Occurs Independently of Enzymatically Generated ADP-Ribose or Cyclic ADP-Ribose by Lund, Frances E, Muller-Steffner, Helene M, Yu, Naixuan, Stout, C. David, Schuber, Francis, Howard, Maureen C

“…CD38 is a type II transmembrane glycoprotein that is expressed by many cell types including lymphocytes. Signaling through CD38 on B lymphocytes can mediate B…”
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Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice by Nomura, T, Han, H, Howard, M C, Yagita, H, Yakura, H, Honjo, T, Tsubata, T

“…Mature B cells undergo programmed cell death when surface (s) Ig is extensively multimerized. A signal that blocks death of B cells is thus required for…”
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Mice Deficient for the Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase CD38 Exhibit Altered Humoral Immune Responses by Cockayne, Debra A., Muchamuel, Tony, Grimaldi, J. Christopher, Muller-Steffner, Hélène, Randall, Troy D., Lund, Frances E., Murray, Richard, Schuber, Francis, Howard, Maureen C.

“…CD38 is a membrane-associated ecto-nicotinamide adenine dinucleotide (NAD+) glycohydrolase that is expressed on multiple hematopoietic cells. The extracellular…”
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CD38: a new paradigm in lymphocyte activation and signal transduction by Lund, Frances E., Cockayne, Debm A., Randall, Troy D., Solvason, Nanette, Schuber, Francis, Howard, Maureen C.

“…CD38 is a type II transmembrane glycoprotein that is extensively expressed on cells of bematopoietic and non‐hematopoietic lineage. Although the intracellular…”
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CD40 signaling induces interleukin-4-independent IgE switching in vivo by Ferlin, W G, Severinson, E, Ström, L, Heath, A W, Coffman, R L, Ferrick, D A, Howard, M C

“…T cell-deficient T cell receptor (TCR) beta-/- x TCR delta-/- knockout mice lack circulating IgE and fail to produce antigen-specific IgE in response to…”
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Mice Deficient for the Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase CD38 Exhibit Altered Humoral Immune Responses by Cockayne, Debra A., Muchamuel, Tony, Grimaldi, J. Christopher, Muller-Steffner, Hélène, Randall, Troy D., Lund, Frances E., Murray, Richard, Schuber, Francis, Howard, Maureen C.

“…CD38 is a membrane-associated ecto-nicotinamide adenine dinucleotide (NAD+) glycohydrolase that is expressed on multiple hematopoietic cells. The extracellular…”
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IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production by Muchamuel, T, Menon, S, Pisacane, P, Howard, MC, Cockayne, DA

“…IL-13 is a potent down-modulator of macrophage proinflammatory activity in vitro, similar in this context to the anti-inflammatory cytokines IL-4 and IL-10…”
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Monoclonal antibodies to murine CD40 define two distinct functional epitopes by Heath, A W, Wu, W W, Howard, M C

“…Two rat IgG2a antibodies which define distinct epitopes on murine CD40 have been generated. These antibodies specifically bind recombinant murine CD40…”
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MHC-based diagnostics and therapeutics – clinical applications for disease-linked genes by Howard, Maureen C, Spack, Edward G, Choudhury, Kalidip, Greten, Tim F, Schneck, Jonathan P

“…Human diseases frequently occur in discrete, genetically susceptible groups rather than being distributed randomly in the population. As discussed at a recent…”
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Signaling through CD38 augments B cell antigen receptor (BCR) responses and is dependent on BCR expression by Lund, FE, Yu, N, Kim, KM, Reth, M, Howard, MC

“…mAbs directed against the ectoenzyme CD38 will induce B cell proliferation in normal resting B lymphocytes, but cannot induce proliferation in B cells that are…”
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Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes by Solvason, N, Wu, W W, Kabra, N, Wu, X, Lees, E, Howard, M C

“…Progression through the cell cycle is a tightly controlled process that integrates signals generated at the plasma membrane with the proteins that form the…”
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Protective effects of IL-4 and IL-10 against immune complex-induced lung injury by Mulligan, MS, Jones, ML, Vaporciyan, AA, Howard, MC, Ward, PA

“…Recombinant murine IL-4 and IL-10 have been used in two models of inflammatory lung injury in rats after intrapulmonary deposition of IgG or IgA immune…”
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The induction of a protective response in Leishmania major‐infected BALB/c mice with anti‐CD40 mAb by Ferlin, Walter G., von der Weid, Thierry, Cottrez, Françoise, Ferrick, David A., Coffman, Robert L., Howard, Maureen C.

“…A protective immune response to the intracellular parasite Leishmania major requires the development of a Th1 CD4+ T cell phenotype. We demonstrate herein that…”
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Expression of Murine CD38 Defines a Population of Long-Term Reconstituting Hematopoietic Stem Cells by Randall, Troy D., Lund, Frances E., Howard, Maureen C., Weissman, Irving L.

“…Using a monoclonal antibody to murine CD38, we showed that a population of adult bone marrow cells that expressed the markers Sca-1 and c-kit but lacked the…”
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