Search Results - "Howard, Marthe J"

Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in Mice by Smith-Edwards, Kristen M., Najjar, Sarah A., Edwards, Brian S., Howard, Marthe J., Albers, Kathryn M., Davis, Brian M.

“…Proper colon function requires signals from extrinsic primary afferent neurons (ExPANs) located in spinal ganglia. Most ExPANs express the vanilloid receptor…”
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Robust, 3-Dimensional Visualization of Human Colon Enteric Nervous System Without Tissue Sectioning by Graham, Kahleb D., López, Silvia Huerta, Sengupta, Rajarshi, Shenoy, Archana, Schneider, Sabine, Wright, Christina M., Feldman, Michael, Furth, Emma, Valdivieso, Federico, Lemke, Amanda, Wilkins, Benjamin J., Naji, Ali, Doolin, Edward J., Howard, Marthe J., Heuckeroth, Robert O.

“…Small, 2-dimensional sections routinely used for human pathology analysis provide limited information about bowel innervation. We developed a technique to…”
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Targeted deletion of Hand2 in enteric neural precursor cells affects its functions in neurogenesis, neurotransmitter specification and gangliogenesis, causing functional aganglionosis by Lei, Jun, Howard, Marthe J

“…Targeted deletion of the bHLH DNA-binding protein Hand2 in the neural crest, impacts development of the enteric nervous system (ENS), possibly by regulating…”
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Cryptochromes Mediate Intrinsic Photomechanical Transduction in Avian Iris and Somatic Striated Muscle by Margiotta, Joseph F, Howard, Marthe J

“…Irises isolated from the eyes of diverse species constrict when exposed to light. Depending on species this intrinsic photomechanical transduction response…”
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Mechanisms and perspectives on differentiation of autonomic neurons by Howard, Marthe J.

“…Neurons share many features in common but are distinguished by expression of phenotypic characteristics that define their specific function, location, or…”
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Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis by Barron, Francie, Woods, Crystal, Kuhn, Katherine, Bishop, Jonathan, Howard, Marthe J, Clouthier, David E

“…Lower jaw development is a complex process in which multiple signaling cascades establish a proximal-distal organization. These cascades are regulated both…”
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Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crest by Vincentz, Joshua W, Firulli, Beth A, Lin, Andrea, Spicer, Douglas B, Howard, Marthe J, Firulli, Anthony B

“…Neural crest cells are multipotent progenitor cells that can generate both ectodermal cell types, such as neurons, and mesodermal cell types, such as smooth…”
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Synaptic Components, Function and Modulation Characterized by GCaMP6f Ca2+ Imaging in Mouse Cholinergic Myenteric Ganglion Neurons by Margiotta, Joseph F., Smith-Edwards, Kristen M., Nestor-Kalinoski, Andrea, Davis, Brian M., Albers, Kathryn M., Howard, Marthe J.

“…The peristaltic contraction and relaxation of intestinal circular and longitudinal smooth muscles is controlled by synaptic circuit elements that impinge upon…”
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Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death by VanDusen, Nathan J., Vincentz, Joshua W., Firulli, Beth A., Howard, Marthe J., Rubart, Michael, Firulli, Anthony B.

“…The Periostin Cre (Postn-Cre) lineage includes endocardial and neural crest derived mesenchymal cells of the cardiac cushions, neural crest-derived components…”
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Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons by Hendershot, Tyler J., Liu, Hongbin, Clouthier, David E., Shepherd, Iain T., Coppola, Eva, Studer, Michèle, Firulli, Anthony B., Pittman, Douglas L., Howard, Marthe J.

“…Neural crest-derived structures that depend critically upon expression of the basic helix–loop–helix DNA binding protein Hand2 for normal development include…”
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Expression of Hand2 is sufficient for neurogenesis and cell type–specific gene expression in the enteric nervous system by Hendershot, Tyler J., Liu, Hongbin, Sarkar, Anjali A., Giovannucci, David R., Clouthier, David E., Abe, Makoto, Howard, Marthe J.

“…The basic helix‐loop‐helix DNA binding protein Hand2 is expressed in neural crest–derived precursors of enteric neurons and has been shown to affect both…”
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Refining Enteric Neural Circuitry by Quantitative Morphology and Function in Mice by Howard, Marthe J

“…RNA-Seq, electrophysiology and optogenetics in mouse models are used to assess function, identify disease related genes and model enteric neural circuits…”
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Sympathetic Input to Multiple Cell Types in Mouse and Human Colon Produces Region-Specific Responses by Smith-Edwards, Kristen M., Edwards, Brian S., Wright, Christina M., Schneider, Sabine, Meerschaert, Kimberly A., Ejoh, Lindsay L., Najjar, Sarah A., Howard, Marthe J., Albers, Kathryn M., Heuckeroth, Robert O., Davis, Brian M.

“…The colon is innervated by intrinsic and extrinsic neurons that coordinate functions necessary for digestive health. Sympathetic input suppresses colon…”
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Simple rules for a “simple” nervous system? Molecular and biomathematical approaches to enteric nervous system formation and malformation by Newgreen, Donald F., Dufour, Sylvie, Howard, Marthe J., Landman, Kerry A.

“…We review morphogenesis of the enteric nervous system from migratory neural crest cells, and defects of this process such as Hirschsprung disease, centering on…”
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Distinct roles of hand2 in developing and adult autonomic neurons by Stanzel, Sabine, Stubbusch, Jutta, Pataskar, Abhijeet, Howard, Marthe J., Deller, Thomas, Ernsberger, Uwe, Tiwari, Vijay K., Rohrer, Hermann, Tsarovina, Konstantina

“…ABSTRACT The bHLH transcription factor Hand2 is essential for the acquisition and maintenance of noradrenergic properties of embryonic sympathetic neurons and…”
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scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3 by Wright, Christina M., Schneider, Sabine, Smith-Edwards, Kristen M., Mafra, Fernanda, Leembruggen, Anita J.L., Gonzalez, Michael V., Kothakapa, Deepika R., Anderson, Jessica B., Maguire, Beth A., Gao, Tao, Missall, Tricia A., Howard, Marthe J., Bornstein, Joel C., Davis, Brian M., Heuckeroth, Robert O.

“…Bowel function requires coordinated activity of diverse enteric neuron subtypes. Our aim was to define gene expression in these neuron subtypes to facilitate…”
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Unique Neural Circuit Connectivity of Mouse Proximal, Middle, and Distal Colon Defines Regional Colonic Motor Patterns by Nestor-Kalinoski, Andrea, Smith-Edwards, Kristen M., Meerschaert, Kimberly, Margiotta, Joseph F., Rajwa, Bartek, Davis, Brian M., Howard, Marthe J.

“…Colonic motor patterns have been described by a number of different groups, but the neural connectivity and ganglion architecture supporting patterned motor…”
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Striking parallels between carotid body glomus cell and adrenal chromaffin cell development by Hockman, Dorit, Adameyko, Igor, Kaucka, Marketa, Barraud, Perrine, Otani, Tomoki, Hunt, Adam, Hartwig, Anna C., Sock, Elisabeth, Waithe, Dominic, Franck, Marina C.M., Ernfors, Patrik, Ehinger, Sean, Howard, Marthe J., Brown, Naoko, Reese, Jeffrey, Baker, Clare V.H.

“…Carotid body glomus cells mediate essential reflex responses to arterial blood hypoxia. They are dopaminergic and secrete growth factors that support…”
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The Endocrine-Disrupting Compound, Nonylphenol, Inhibits Neurotrophin-Dependent Neurite Outgrowth by Bevan, Cassandra L, Porter, Donna M, Schumann, Christopher R, Bryleva, Elena Y, Hendershot, Tyler J, Liu, Hongbin, Howard, Marthe J, Henderson, Leslie P

“…Endocrine-disrupting compounds (EDCs) may interfere with neuronal development due to high levels of accumulation in biological tissue and potentially aberrant…”
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The bHLH transcription factor Hand2 is essential for the maintenance of noradrenergic properties in differentiated sympathetic neurons by Schmidt, Mirko, Lin, Shengyin, Pape, Manuela, Ernsberger, Uwe, Stanke, Matthias, Kobayashi, Kazuto, Howard, Marthe J., Rohrer, Hermann

“…The basic helix–loop–helix transcription factor Hand2 is essential for the proliferation and noradrenergic differentiation of sympathetic neuron precursors…”
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