Search Results - "Howard, Mark J."

Elucidation of the biosynthesis of the methane catalyst coenzyme F430 by Moore, Simon J., Sowa, Sven T., Schuchardt, Christopher, Deery, Evelyne, Lawrence, Andrew D., Ramos, José Vazquez, Billig, Susan, Birkemeyer, Claudia, Chivers, Peter T., Howard, Mark J., Rigby, Stephen E. J., Layer, Gunhild, Warren, Martin J.

“…Methane biogenesis in methanogens is mediated by methyl-coenzyme M reductase, an enzyme that is also responsible for the utilization of methane through…”
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Membrane remodeling by the M2 amphipathic helix drives influenza virus membrane scission by Martyna, Agnieszka, Bahsoun, Basma, Badham, Matthew D., Srinivasan, Saipraveen, Howard, Mark J., Rossman, Jeremy S.

“…Membrane scission is a crucial step in all budding processes, from endocytosis to viral budding. Many proteins have been associated with scission, though the…”
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Recent developments and applications of saturation transfer difference nuclear magnetic resonance (STD NMR) spectroscopy by Wagstaff, Jane L, Taylor, Samantha L, Howard, Mark J

“…This review aims to illustrate that STD NMR is not simply a method for drug screening and discovery, but has qualitative and quantitative applications that can…”
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Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B₁₂) by Moore, Simon J., Lawrence, Andrew D., Biedendieck, Rebekka, Deery, Evelyne, Frank, Stefanie, Howard, Mark J., Rigby, Stephen E. J., Warren, Martin J.

“…It has been known for the past 20 years that two pathways exist in nature for the de novo biosynthesis of the coenzyme form of vitamin B ₁₂, adenosylcobalamin,…”
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CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress by Holyoake, Louise V, Hunt, Stuart, Sanguinetti, Guido, Cook, Gregory M, Howard, Mark J, Rowe, Michelle L, Poole, Robert K, Shepherd, Mark

“…The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli. A cydD mutant strain was used to probe the influence of CydDC upon reduced…”
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Construction of Fluorescent Analogs to Follow the Uptake and Distribution of Cobalamin (Vitamin B 12 ) in Bacteria, Worms, and Plants by Lawrence, Andrew D, Nemoto-Smith, Emi, Deery, Evelyne, Baker, Joseph A, Schroeder, Susanne, Brown, David G, Tullet, Jennifer M A, Howard, Mark J, Brown, Ian R, Smith, Alison G, Boshoff, Helena I, Barry, 3rd, Clifton E, Warren, Martin J

“…Vitamin B is made by only certain prokaryotes yet is required by a number of eukaryotes such as mammals, fish, birds, worms, and Protista, including algae…”
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New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis by Bastow, Emma L, Peswani, Amber R, Tarrant, Daniel S J, Pentland, Daniel R, Chen, Xi, Morgan, Alan, Staniforth, Gemma L, Tullet, Jennifer M, Rowe, Michelle L, Howard, Mark J, Tuite, Mick F, Gourlay, Campbell W

“…A number of genes have been linked to familial forms of the fatal motor neuron disease amyotrophic lateral sclerosis (ALS). Over 150 mutations within the gene…”
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Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses by Pappalardo, Morena, Juliá, Miguel, Howard, Mark J., Rossman, Jeremy S., Michaelis, Martin, Wass, Mark N.

“…Reston viruses are the only Ebolaviruses that are not pathogenic in humans. We analyzed 196 Ebolavirus genomes and identified specificity determining positions…”
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Fully Collapsed Imploded Cryptophanes in Solution and in the Solid State by Thorp‐Greenwood, Flora L., Howard, Mark J., Kuhn, Lars T., Hardie, Michaele J.

“…Cryptophanes with flexible linkers derived from (±)‐tris‐(4‐formyl‐phenyl)‐cyclotriguaiacylene with either bisoxydi(ethylamine) or bis(aminopropyl)ether were…”
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Structural Definition Is Important for the Propagation of the Yeast [PSI+] Prion by Marchante, Ricardo, Rowe, Michelle, Zenthon, Jo, Howard, Mark J., Tuite, Mick F.

“…Prions are propagated in Saccharomyces cerevisiae with remarkable efficiency, yet we know little about the structural basis of sequence variations in the prion…”
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An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis by Deery, Evelyne, Schroeder, Susanne, Lawrence, Andrew D, Taylor, Samantha L, Seyedarabi, Arefeh, Waterman, Jitka, Wilson, Keith S, Brown, David, Geeves, Michael A, Howard, Mark J, Pickersgill, Richard W, Warren, Martin J

“…The use of abbreviated pathway constructs leads to trapping of a series of cobalamin intermediates, allowing assignment of the full biosynthetic pathway and…”
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An Evaluation of the Potential of NMR Spectroscopy and Computational Modelling Methods to Inform Biopharmaceutical Formulations by Pandya, Akash, Howard, Mark J, Zloh, Mire, Dalby, Paul A

“…Protein-based therapeutics are considered to be one of the most important classes of pharmaceuticals on the market. The growing need to prolong stability of…”
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Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway by Irvine, Alistair G, Wallis, A Katrine, Sanghera, Narinder, Rowe, Michelle L, Ruddock, Lloyd W, Howard, Mark J, Williamson, Richard A, Blindauer, Claudia A, Freedman, Robert B

“…In contrast to molecular chaperones that couple protein folding to ATP hydrolysis, protein disulfide-isomerase (PDI) catalyzes protein folding coupled to…”
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Mapping of the ligand-binding site on the b' domain of human PDI: interaction with peptide ligands and the x-linker region by Byrne, Lee J, Sidhu, Ateesh, Wallis, A Katrine, Ruddock, Lloyd W, Freedman, Robert B, Howard, Mark J, Williamson, Richard A

“…PDI (protein disulfide-isomerase) catalyses the formation of native disulfide bonds of secretory proteins in the endoplasmic reticulum. PDI consists of four…”
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Alternative Conformations of the x Region of Human Protein Disulphide-Isomerase Modulate Exposure of the Substrate Binding b’ Domain by Nguyen, Van Dat, Wallis, Katrine, Howard, Mark J., Haapalainen, Antti M., Salo, Kirsi E.H., Saaranen, Mirva J., Sidhu, Ateesh, Wierenga, Rik K., Freedman, Robert B., Ruddock, Lloyd W., Williamson, Richard A.

“…Protein disulphide isomerase (PDI) is a key multi-domain protein folding catalyst in the endoplasmic reticulum. The b’ domain of PDI is essential for the…”
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NMR metabolomics reveals effects of Cryptosporidium infections on host cell metabolome by Miller, Christopher N, Panagos, Charalampos G, Mosedale, William R T, Kváč, Martin, Howard, Mark J, Tsaousis, Anastasios D

“…is an important gut microbe whose contributions towards infant and immunocompromise patient mortality rates are steadily increasing. Over the last decade, we…”
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Comparison of the effects of 2,2,2-trifluoroethanol on peptide and protein structure and function by Povey, Jane F., Smales, C. Mark, Hassard, Stuart J., Howard, Mark J.

“…The co-solvent 2,2,2-trifluoroethanol (TFE) has been often used to aid formation of secondary structure in solution peptides or alternately as a denaturant…”
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Solution state nuclear magnetic resonance spectroscopy for biological metabolism and pathway intermediate analysis by Nealon, Gareth L, Howard, Mark J

“…Using nuclear magnetic resonance (NMR) spectroscopy in the study of metabolism has been immensely popular in medical- and health-related research but has yet…”
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High-resolution NMR studies of structure and dynamics of human ERp27 indicate extensive interdomain flexibility by Amin, Nader T, Wallis, A Katrine, Wells, Stephen A, Rowe, Michelle L, Williamson, Richard A, Howard, Mark J, Freedman, Robert B

“…ERp27 (endoplasmic reticulum protein 27.7 kDa) is a homologue of PDI (protein disulfide-isomerase) localized to the endoplasmic reticulum. ERp27 is predicted…”
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Foot-and-Mouth Disease Virus Forms a Highly Stable, EDTA-Resistant Complex with Its Principal Receptor, Integrin αvβ6: Implications for Infectiousness by DICARA, Danielle, BURMAN, Alison, CLARK, Stuart, BERRYMAN, Stephen, HOWARD, Mark J, HART, Ian R, MARSHALL, John F, JACKSON, Terry

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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