Search Results - "Howard, M O"

Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells by Yoshimura, Teizo, Howard, O M Zack, Ito, Toshihiro, Kuwabara, Masaki, Matsukawa, Akihiro, Chen, Keqiang, Liu, Ying, Liu, Mingyong, Oppenheim, Joost J, Wang, Ji Ming

“…MCP-1/CCL2 plays an important role in the initiation and progression of cancer. Since tumor cells produce MCP-1, they are considered to be the main source of…”
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Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells by Kopf, Heather, de la Rosa, Gonzalo M., Howard, O.M.Zack, Chen, Xin

“…Reciprocal differentiation of immunosuppressive CD4+CD25+FoxP3+ T regulatory cells (Tregs) and proinflammatory IL-17-producing cells (Th17) from naïve CD4…”
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Leukocyte-derived koebnerisin (S100A15) and psoriasin (S100A7) are systemic mediators of inflammation in psoriasis by Batycka-Baran, Aleksandra, Hattinger, Eva, Zwicker, Stephanie, Summer, Burkhard, Zack Howard, O.M, Thomas, Peter, Szepietowski, Jacek C, Ruzicka, Thomas, Prinz, Jörg C, Wolf, Ronald

“…Highlights • Leukocytes are a novel source of koebnerisin (S100A15) and psoriasin (S100A7). • Koebnerisin and psoriasin are induced in leukocytes of patients…”
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Painful pathways induced by TLR stimulation of dorsal root ganglion neurons by Qi, Jia, Buzas, Krisztina, Fan, Huiting, Cohen, Jeffrey I, Wang, Kening, Mont, Erik, Klinman, Dennis, Oppenheim, Joost J, Howard, O M Zack

“…We hypothesize that innate immune signals from infectious organisms and/or injured tissues may activate peripheral neuronal pain signals. In this study, we…”
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β-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-α production by human plasmacytoid dendritic cells, and promote inflammation by Tewary, Poonam, de la Rosa, Gonzalo, Sharma, Neeraj, Rodriguez, Luis G, Tarasov, Sergey G, Howard, O M Zack, Shirota, Hidekazu, Steinhagen, Folkert, Klinman, Dennis M, Yang, De, Oppenheim, Joost J

“…Alarmins are a group of structurally diverse host defense antimicrobial peptides that are important immune activators. In this article, we present a novel role…”
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Glucocorticoid amplifies IL‐2‐dependent expansion of functional FoxP3+CD4+CD25+ T regulatory cells in vivo and enhances their capacity to suppress EAE by Chen, Xin, Oppenheim, Joost J., Winkler‐Pickett, Robin T., Ortaldo, John R., Howard, O. M. Zack

“…IL‐2 is crucial for the production of CD4+CD25+ T regulatory (Treg) cells while important for the generation of effective T cell‐mediated immunity. How to…”
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Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways by Zhao, Zhizheng, Fan, Huiting, Higgins, Tim, Qi, Jia, Haines, Diana, Trivett, Anna, Oppenheim, Joost J, Wei, Hou, Li, Jie, Lin, Hongsheng, Howard, O.M. Zack

“…Highlights • Cancer Pain correlates with TRPV1-mediated ERK phosphorylation. • Fufang Kushen Injection reduces thermal hyperalgesia induced by sarcoma. •…”
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Cellular pharmacology studies of shikonin derivatives by Chen, Xin, Yang, Lu, Oppenheim, Joost J., Howard, O. M. Zack

“…The naphthoquinone pigment, shikonin, isolated from Lithospermum erythrorhizon Sieb. et Zucc.(Boraginaceae) and its derivatives are the active components…”
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β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6 by Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., Oppenheim, J. J.

“…Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human β-defensins are also chemotactic…”
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Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1 by XIN CHEN, LU YANG, NING ZHANG, TURPIN, Jim A, BUCKHEIT, Robert W, OSTERLING, Clay, OPPENHEIM, Joost J, HOWARD, O. M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Tumor-Infiltrating Myeloid Cells Co-Express TREM1 and TREM2 and Elevated TREM-1 Associates With Disease Progression in Renal Cell Carcinoma by Ford, Jill W, Gonzalez-Cotto, Marieli, MacFarlane, 4th, Alexander W, Peri, Suraj, Howard, O M Zack, Subleski, Jeffrey J, Ruth, Karen J, Haseebuddin, Mohammed, Al-Saleem, Tahseen, Yang, Youfeng, Rayman, Pat, Rini, Brian, Linehan, W Marston, Finke, James, Weiss, Jonathan M, Campbell, Kerry S, McVicar, Daniel W

“…Myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) contribute to cancer-related inflammation and tumor progression. While several…”
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Formylpeptide Receptor FPR and the Rapid Growth of Malignant Human Gliomas by Zhou, Ye, Bian, Xiuwu, Le, Yingying, Gong, Wanghua, Hu, Jinyue, Zhang, Xia, Wang, Lihua, Iribarren, Pablo, Salcedo, Rosalba, Howard, O. M. Zack, Farrar, William, Wang, Ji Ming

“…Background: The formylpeptide receptor (FPR) is a G-protein–coupled receptor (GPCR) that mediates chemotaxis of phagocytic leukocytes induced by bacterial…”
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Myeloid cells migrate in response to IL-24 by Buzas, Krisztina, Oppenheim, Joost J., Zack Howard, O.M.

“…► IL-24 induces human monocyte and neutrophil migration, in vitro. ► IL-24 attracted CD11b positive murine myeloid cells, in vivo. ► Pertussis toxin, MEK and…”
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Gene from a psoriasis susceptibility locus primes the skin for inflammation by Wolf, Ronald, Mascia, Francesca, Dharamsi, Alif, Howard, O M Zack, Cataisson, Christophe, Bliskovski, Val, Winston, Jason, Feigenbaum, Lionel, Lichti, Ulrike, Ruzicka, Thomas, Chavakis, Triantafyllos, Yuspa, Stuart H

“…Psoriasis is a common complex genetic disease characterized by hyperplasia and inflammation in the skin; however, the relative contributions of epidermal cells…”
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Alarmin‐induced cell migration by Yang, De, Wei, Feng, Tewary, Poonam, Howard, O. M. Zack, Oppenheim, Joost J.

“…Alarmins are endogenous, constitutively available, damage‐associated molecular patterns that upon release can mobilize and activate various leukocytes for the…”
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Interleukin-8-like activity in a filarial asparaginyl-tRNA synthetase by Kron, Michael A., Wang, Cheng, Vodanovic-Jankovic, Sanja, Zack Howard, O.M., Kuhn, Leslie A.

“…[Display omitted] Brugia malayi AsnRS has IL-8 like activity. ► IL-8-like activity resides in the tRNA binding domain of the filarial AsnRS. ► Structural…”
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Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation by Malik, Mariam, Jividen, Kasey, Padmakumar, V. C, Cataisson, Christophe, Li, Luowei, Lee, Jessica, Howard, O. M. Zack, Yuspa, Stuart H

“…Nuclear translocation of cytosolic CLIC4 is an essential feature of its proapoptotic and prodifferentiation functions. Here we demonstrate that CLIC4 is…”
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Pertussis Toxin by Inducing IL-6 Promotes the Generation of IL-17-Producing CD4 Cells by Chen, Xin, Howard, O. M. Zack, Oppenheim, Joost J

“…Compelling evidence has now demonstrated that IL-17-producing CD4 cells (Th17) are a major contributor to autoimmune pathogenesis, whereas CD4+CD25+ T…”
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Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking by Chen, Xin, Murakami, Takaya, Oppenheim, Joost J., Howard, O. M. Zack

“…Triptolide (TPT) is a chemically defined, potent immunosuppressive compound isolated from an anti-inflammatory Chinese herbal medicine. TPT has been reported…”
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Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells by Chen, Xin, Winkler‐Pickett, Robin T., Carbonetti, Nicholas H., Ortaldo, John R., Oppenheim, Joost J., Howard, O. M. Zack

“…We observed a remarkable reduction in the frequency and immunosuppressive activity of splenic CD4+CD25+ T cells in C57BL/6 mice with MOG33–55‐induced…”
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