Search Results - "Howard, Laurence M"

Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis by Foster, Carolyn A, Howard, Laurence M, Schweitzer, Alain, Persohn, Elke, Hiestand, Peter C, Balatoni, Balázs, Reuschel, Roland, Beerli, Christian, Schwartz, Manuela, Billich, Andreas

“…FTY720 [2-amino-2-[2-(4-octylphenyl) ethyl]propane-1,3-diol hydrochloride] is an oral sphingosine-1-phosphate receptor modulator under development for the…”
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FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood-Brain-Barrier Damage by Foster, Carolyn A., Mechtcheriakova, Diana, Storch, Maria K., Balatoni, Balázs, Howard, Laurence M., Bornancin, Frédéric, Wlachos, Alexander, Sobanov, Jury, Kinnunen, Anu, Baumruker, Thomas

“…FTY720 (fingolimod) is an oral sphingosine‐1 phosphate (S1P) receptor modulator in phase III development for the treatment of multiple sclerosis. To further…”
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CD154 Blockade Results in Transient Reduction in Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease by Howard, Laurence M, Neville, Katherine L, Haynes, Lia M, Dal Canto, Mauro C, Miller, Stephen D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis by Howard, L M, Miga, A J, Vanderlugt, C L, Dal Canto, M C, Laman, J D, Noelle, R J, Miller, S D

“…Relapsing experimental autoimmune encephalomyelitis (R-EAE) in the SJL mouse is a Th1-mediated autoimmune demyelinating disease model for human multiple…”
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Transient anti-CD154-mediated immunotherapy of ongoing relapsing experimental autoimmune encephalomyelitis induces long-term inhibition of disease relapses by Howard, Laurence M, Dal Canto, Mauro C, Miller, Stephen D

“…Relapsing experimental autoimmune encephalomyelitis (R-EAE) is a Th1-mediated central nervous system (CNS) autoimmune disease with pathology similar to that of…”
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Immunotherapy Targeting the CD40/CD154 Costimulatory Pathway for Treatment of Autoimmune Disease by Howard, Laurence M., Miller, Stephen D.

“…The CD154-CD40 ligand pair interaction plays a central role in both induction of the immune response and in immune effector functions. Indeed, many animal…”
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Autoimmune Intervention by CD154 Blockade Prevents T Cell Retention and Effector Function in the Target Organ by Howard, Laurence M, Miller, Stephen D

“…The CD40-CD154 interaction is an attractive target for therapeutic intervention in many autoimmune disorders, including multiple sclerosis. Previously, we…”
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Normal Th1 development following long-term therapeutic blockade of CD154-CD40 in experimental autoimmune encephalomyelitis by Howard, Laurence M, Ostrovidov, Serge, Smith, Cassandra E, Dal Canto, Mauro C, Miller, Stephen D

“…Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated demyelinating disease of the CNS with similarities to multiple sclerosis. We and others have…”
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Therapeutic blockade of TCR signal transduction and co-stimulation in autoimmune disease by Howard, Laurence M, Kohm, Adam P, Castaneda, Carol L, Miller, Stephen D

“…Autoimmune diseases are initiated and maintained by presentation of self antigen through complex interactions between different cells of the immune system. In…”
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The functional significance of epitope spreading and its regulation by co-stimulatory molecules by Vanderlugt, Carol L., Begolka, Wendy Smith, Neville, Katherine L., Katz-Levy, Yael, Howard, Laurence M., Eagar, Todd N., Bluestone, Jeffrey A., Miller, Stephen D.

“…Epitope spreading is a process whereby epitopes distinct from and non‐cross‐reactive with an inducing epitope become major targets of an ongoing immune…”
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Immunotherapy targeting the CD40/CD154 costimulatory pathway for treatment of autoimmune disease: Microbes and autoimmunity by HOWARD, Laurence M, MILLER, Stephen D

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Restoration of ethanol‐compromised Th1 responses by sodium orthovanadate by Ostrovidov, Serge, Howard, Laurence M., Ikeda, Masato, Ikeda, Akiko, Waltenbaugh, Carl

“…Alcohol consumption often diminishes antigen‐specific cell‐mediated immunity. In alcohol‐consuming mice IFN‐γ and delayed‐type hypersensitivity (DTH) responses…”
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Normal Th1 development following long-term therapeutic blockade of CD154-CD40 in experimental autoimmune encephalomyelitis by Howard, Laurence M., Ostrovidov, Serge, Smith, Cassandra E., Dal Canto, Mauro C., Miller, Stephen D.

“…Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated demyelinating disease of the CNS with similarities to multiple sclerosis. We and others have…”
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Restoration of ethanol-compromised T(h)1 responses by sodium orthovanadate by Ostrovidov, Serge, Howard, Laurence M, Ikeda, Masato, Ikeda, Akiko, Waltenbaugh, Carl

“…Alcohol consumption often diminishes antigen-specific cell-mediated immunity. In alcohol-consuming mice IFN-gamma and delayed-type hypersensitivity (DTH)…”
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Mouse models of multiple sclerosis: experimental autoimmune encephalomyelitis and Theiler's virus-induced demyelinating disease by Fuller, Kevin G, Olson, Julie K, Howard, Laurence M, Croxford, J Ludovic, Miller, Stephen D

“…Experimental autoimmune encephalomyelitis (EAE) and Theiler's murine encephalitis virus-induced demyelinating disease (TMEV-IDD) are two clinically relevant…”
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CD72 Ligation Regulates Defective Naive Newborn B Cell Responses by Howard, Laurence M., Reen, Denis J.

“…The biological basis for reduced Ig production by naive newborn B cells compared to adult peripheral blood B cells is not fully understood. In a Con A + IL-2 T…”
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