Search Results - "Howard, Jonathan"

The RNAissance family: SR proteins as multifaceted regulators of gene expression by Howard, Jonathan M., Sanford, Jeremy R.

“…Serine and arginine‐rich (SR) proteins play multiple roles in the eukaryotic gene expression pathway. Initially described as constitutive and alternative…”
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Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii by Steinfeldt, Tobias, Könen-Waisman, Stephanie, Tong, Lan, Pawlowski, Nikolaus, Lamkemeyer, Tobias, Sibley, L David, Hunn, Julia P, Howard, Jonathan C

“…Virulence of complex pathogens in mammals is generally determined by multiple components of the pathogen interacting with the functional complexity and…”
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Irgm2 and Gate‐16 cooperatively dampen Gram‐negative bacteria‐induced caspase‐11 response by Eren, Elif, Planès, Rémi, Bagayoko, Salimata, Bordignon, Pierre‐Jean, Chaoui, Karima, Hessel, Audrey, Santoni, Karin, Pinilla, Miriam, Lagrange, Brice, Burlet‐Schiltz, Odile, Howard, Jonathan C, Henry, Thomas, Yamamoto, Masahiro, Meunier, Etienne

“…Inflammatory caspase‐11 (rodent) and caspases‐4/5 (humans) detect the Gram‐negative bacterial component LPS within the host cell cytosol, promoting activation…”
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Who only stand and wait by Howard, Jonathan L.

“…For services rendered. Ready to serve…”
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A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins by Fleckenstein, Martin C, Reese, Michael L, Könen-Waisman, Stephanie, Boothroyd, John C, Howard, Jonathan C, Steinfeldt, Tobias

“…The ability of mice to resist infection with the protozoan parasite, Toxoplasma gondii, depends in large part on the function of members of a complex family of…”
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The Everywhere Bus by Howard, Jonathan L.

“…It's the latest in travel technology…”
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RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation by Palanichamy, Jayanth Kumar, Tran, Tiffany M, Howard, Jonathan M, Contreras, Jorge R, Fernando, Thilini R, Sterne-Weiler, Timothy, Katzman, Sol, Toloue, Masoud, Yan, Weihong, Basso, Giuseppe, Pigazzi, Martina, Sanford, Jeremy R, Rao, Dinesh S

“…Posttranscriptional control of gene expression is important for defining both normal and pathological cellular phenotypes. In vitro, RNA-binding proteins…”
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The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii by Howard, Jonathan C, Hunn, Julia P, Steinfeldt, Tobias

“…Highlights ► Up to 18 IRG proteins defend mice against Toxoplasma gondii and two Chlamydia species, but not against several other organisms. ► IRG proteins…”
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Epidemiology of Multiple Sclerosis by Howard, Jonathan, MD, Trevick, Stephen, MD, Younger, David S., MD, MPH, MS

“…The epidemiology of multiple sclerosis (MS) includes a consideration of genetic and environmental factors. Comparative studies of different populations have…”
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Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases by Martens, Sascha, Parvanova, Iana, Zerrahn, Jens, Griffiths, Gareth, Schell, Gudrun, Reichmann, Gaby, Howard, Jonathan C

“…The p47 GTPases are essential for interferon-gamma-induced cell-autonomous immunity against the protozoan parasite, Toxoplasma gondii, in mice, but the…”
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Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy by Reid, Adam James, Vermont, Sarah J, Cotton, James A, Harris, David, Hill-Cawthorne, Grant A, Könen-Waisman, Stephanie, Latham, Sophia M, Mourier, Tobias, Norton, Rebecca, Quail, Michael A, Sanders, Mandy, Shanmugam, Dhanasekaran, Sohal, Amandeep, Wasmuth, James D, Brunk, Brian, Grigg, Michael E, Howard, Jonathan C, Parkinson, John, Roos, David S, Trees, Alexander J, Berriman, Matthew, Pain, Arnab, Wastling, Jonathan M

“…Toxoplasma gondii is a zoonotic protozoan parasite which infects nearly one third of the human population and is found in an extraordinary range of vertebrate…”
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Friend or Foe: A Review and Synthesis of Computational Models of the Identity Labeling Problem by Joseph, Kenneth, Morgan, Jonathan Howard

“…We introduce the identity labeling problem - given an individual in a social situation, can we predict what identity(ies) they will be labeled with by someone…”
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A Class of Iron Chelators with a Wide Spectrum of Potent Antitumor Activity That Overcomes Resistance to Chemotherapeutics by Whitnall, Megan, Howard, Jonathan, Ponka, Prem, Richardson, Des R.

“…Novel chemotherapeutics with marked and selective antitumor activity are essential to develop, particularly those that can overcome resistance to established…”
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The impact of Toxoplasma gondii on the mammalian genome by Müller, Urs B, Howard, Jonathan C

“…Highlights • Correlating specific genomic modifications with particular infections is difficult. • T. gondii is a ubiquitous parasite but depends on infection…”
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James L. Gowans 1924–2020 by Howard, Jonathan C., Weissman, Irving L.

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The IRG proteins: A function in search of a mechanism by Howard, Jonathan

“…Abstract The IRG proteins (p47 GTPases) constitute one of the strongest resistance systems known to be active against intracellular pathogens in mice. The…”
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Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNγ-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death by Zhao, Yang O, Khaminets, Aliaksandr, Hunn, Julia P, Howard, Jonathan C

“…Toxoplasma gondii is a natural intracellular protozoal pathogen of mice and other small mammals. After infection, the parasite replicates freely in many cell…”
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Predicting transfer RNA gene activity from sequence and genome context by Thornlow, Bryan P, Armstrong, Joel, Holmes, Andrew D, Howard, Jonathan M, Corbett-Detig, Russell B, Lowe, Todd M

“…Transfer RNA (tRNA) genes are among the most highly transcribed genes in the genome owing to their central role in protein synthesis. However, there is…”
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Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men by Gazzinelli, Ricardo T., Mendonça-Neto, Rondon, Lilue, Jingtao, Howard, Jonathan, Sher, Alan

“…Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins…”
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Loss of exon identity is a common mechanism of human inherited disease by Sterne-Weiler, Timothy, Howard, Jonathan, Mort, Matthew, Cooper, David N, Sanford, Jeremy R

“…It is widely accepted that at least 10% of all mutations causing human inherited disease disrupt splice-site consensus sequences. In contrast to splice-site…”
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