Search Results - "Howard, James"

Myasthenia gravis: the role of complement at the neuromuscular junction by Howard, James F.

“…Generalized myasthenia gravis (gMG) is a rare autoimmune disorder characterized by skeletal muscle weakness caused by disrupted neurotransmission at the…”
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De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: A systematic review and meta-analysis of current clinical trials by Masterson, Liam, Moualed, Daniel, Liu, Zi Wei, Howard, James E.F, Dwivedi, Raghav C, Tysome, James R, Benson, Richard, Sterling, Jane C, Sudhoff, Holger, Jani, Piyush, Goon, Peter K.C

“…Abstract Iatrogenic complications associated with current treatment protocols for oropharyngeal squamous cell carcinoma are noted to cause high rates of acute…”
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Identity-Specific Reward Representations in Orbitofrontal Cortex Are Modulated by Selective Devaluation by Howard, James D, Kahnt, Thorsten

“…Goal-directed behavior is sensitive to the current value of expected outcomes. This requires independent representations of specific rewards, which have been…”
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Identity prediction errors in the human midbrain update reward-identity expectations in the orbitofrontal cortex by Howard, James D., Kahnt, Thorsten

“…There is general consensus that dopaminergic midbrain neurons signal reward prediction errors, computed as the difference between expected and received reward…”
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Age-related differences in multiple measures of white matter integrity: A diffusion tensor imaging study of healthy aging by Bennett, Ilana J., Madden, David J., Vaidya, Chandan J., Howard, Darlene V., Howard Jr, James H.

“…Diffusion tensor imaging (DTI) measures diffusion of molecular water, which can be used to calculate indices of white matter integrity. Early DTI studies of…”
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Meta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation by Ahmad, Yousif, Howard, James P.

“…One of the most feared complications of transcatheter aortic valve implantation (TAVI) is stroke, with increased mortality and disability observed in patients…”
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Long-term efficacy and safety of ravulizumab in adults with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis: results from the phase 3 CHAMPION MG open-label extension by Meisel, Andreas, Annane, Djillali, Vu, Tuan, Mantegazza, Renato, Katsuno, Masahisa, Aguzzi, Rasha, Frick, Glen, Gault, Laura, Howard, James F.

“…Introduction Ravulizumab demonstrated efficacy and an acceptable safety profile versus placebo in the randomized controlled period (RCP) of the phase 3…”
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Ligand binding to the FeMo-cofactor: Structures of CO-bound and reactivated nitrogenase by Spatzal, Thomas, Perez, Kathryn A., Einsle, Oliver, Howard, James B., Rees, Douglas C.

“…The mechanism of nitrogenase remains enigmatic, with a major unresolved issue concerning how inhibitors and substrates bind to the active site.We report a…”
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Guidance for the management of myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) during the COVID-19 pandemic by Jacob, Saiju, Muppidi, Srikanth, Guidon, Amanda, Guptill, Jeffrey, Hehir, Michael, Howard, James F., Illa, Isabel, Mantegazza, Renato, Murai, Hiroyuki, Utsugisawa, Kimiaki, Vissing, John, Wiendl, Heinz, Nowak, Richard J.

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To Be Specific: The Role of Orbitofrontal Cortex in Signaling Reward Identity by Howard, James D., Kahnt, Thorsten

“…The orbitofrontal cortex (OFC) plays a prominent role in signaling reward expectations. Two important features of rewards are their value (how good they are)…”
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Differential Representations of Prior and Likelihood Uncertainty in the Human Brain by Vilares, Iris, Howard, James D., Fernandes, Hugo L., Gottfried, Jay A., Kording, Konrad P.

“…Uncertainty shapes our perception of the world and the decisions we make. Two aspects of uncertainty are commonly distinguished: uncertainty in previously…”
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Surgical Approach in Primary Total Hip Arthroplasty: Anatomy Technique and Clinical Outcomes by Petis, Stephen, MD, MSc, Howard, James L., MD, MSc, Lanting, Brent L., MD, MSc, Vasarhelyi, Edward M, MD, MSc

“…Total hip arthroplasty (THA) has revolutionized the treatment of hip arthritis. A number of surgical approaches to the hip joint exist, each with unique…”
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Mental Representations Mediate Aversive Learning in Humans by Qiao, Xiaolin, Wolters, Lauren, Howard, James D.

“…Mental representations of stimuli that are not physically present are critical for a range of cognitive capacities, including perception, memory, and learning…”
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Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis by Kelshiker, Mihir A, Seligman, Henry, Howard, James P, Rahman, Haseeb, Foley, Michael, Nowbar, Alexandra N, Rajkumar, Christopher A, Shun-Shin, Matthew J, Ahmad, Yousif, Sen, Sayan, Al-Lamee, Rasha, Petraco, Ricardo

“…Abstract Aims This meta-analysis aims to quantify the association of reduced coronary flow with all-cause mortality and major adverse cardiovascular events…”
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Grid-like Neural Representations Support Olfactory Navigation of a Two-Dimensional Odor Space by Bao, Xiaojun, Gjorgieva, Eva, Shanahan, Laura K., Howard, James D., Kahnt, Thorsten, Gottfried, Jay A.

“…Searching for food, friends, and mates often begins with an airborne scent. Importantly, odor concentration rises with physical proximity to an odorous source,…”
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From Gadolinium to Generative AI: The Quest for Contrast-Free Cardiac Imaging by Howard, James P, Cheung, Hoi Ching

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Complement Inhibitor Therapy for Myasthenia Gravis by Albazli, Khaled, Kaminski, Henry J, Howard, Jr, James F

“…Complement activation as a driver of pathology in myasthenia gravis (MG) has been appreciated for decades. The terminal complement component [membrane attack…”
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Configural and Elemental Coding of Natural Odor Mixture Components in the Human Brain by Howard, James D., Gottfried, Jay A.

“…Most real-world odors are complex mixtures of distinct molecular components. Olfactory systems can adopt different strategies to contend with this stimulus…”
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Sleep Does Not Benefit Probabilistic Motor Sequence Learning by Song, Sunbin, Howard, James H., Jr, Howard, Darlene V

“…It has become widely accepted that sleep-dependent consolidation occurs for motor sequence learning based on studies using finger-tapping tasks. Studies using…”
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Safety and clinical activity of autologous RNA chimeric antigen receptor T-cell therapy in myasthenia gravis (MG-001): a prospective, multicentre, open-label, non-randomised phase 1b/2a study by Granit, Volkan, Benatar, Michael, Kurtoglu, Metin, Miljković, Miloš D, Chahin, Nizar, Sahagian, Gregory, Feinberg, Marc H, Slansky, Adam, Vu, Tuan, Jewell, Christopher M, Singer, Michael S, Kalayoglu, Murat V, Howard, James F, Mozaffar, Tahseen, Granit, Volkan, Benatar, Michael, Mozaffar, Tahseen, Chahin, Nizar, Howard, James F., Slansky, Adam D., Feinberg, Marc H., Sahagian, Gregory, Vu, Tuan, Pereira, Denise, Steele, Julie, Paredes, Maria Elena, Benjamin, Cara, Komanduri, Krishna, Habib, Ali Aamer, Fong, Julia Kimberly, De La Cruz, Luis, Dimitrova, Diana, Chopra, Manisha, Holley, Kelly, DeMaria, Gabrielle, Tenorio, April, Requena, Naraly, Brooks, Beverly Mackanzie, Suresh, Niraja, Farias, Jerrica, Miljković, Miloš D, Kurtoglu, Metin, Ngo Casi, Minhtran, Chowdhury, Adam, Kamboh, Hafsa, Stewart, C Andrew, Tosun, Mehmet, Shan, Yufei, Daniel, Shaji, Duvernay, Matthew T., Kireeva, Maria, English, Emily, Jewell, Christopher M., Singer, Michael S, Kalayoglu, Murat V

“…Chimeric antigen receptor (CAR) T cells are highly effective in treating haematological malignancies, but associated toxicities and the need for…”
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