Search Results - "Hovanky, Vanna"
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Idecabtagene vicleucel chimeric antigen receptor T-cell therapy for relapsed/refractory multiple myeloma with renal impairment
Published in Haematologica (Roma) (01-03-2024)“…We evaluated patients with relapsed multiple myeloma with renal impairment (RI) treated with standard of care idecabtagene vicleucel (ide-cel), as outcomes…”
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Bendamustine vs. fludarabine/cyclophosphamide lymphodepletion prior to BCMA CAR-T cell therapy in multiple myeloma
Published in Blood cancer journal (New York) (13-10-2023)Get full text
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160 Circulating tumor DNA for measurable residual disease (MRD) detection in multiple myeloma patients undergoing CAR T-cell therapy
Published in Journal for immunotherapy of cancer (01-11-2023)“…BackgroundMeasurable residual disease (MRD) is an important predictor of survival outcomes in both newly diagnosed and relapsed/refractory multiple myeloma…”
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Disease Characterization and Response Prediction in Myeloma Patients Undergoing Conventional and Cellular Therapies from Circulating Tumor DNA
Published in Blood (15-11-2022)Get full text
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Fludarabine Lymphodepletion Exposure Is Associated with Idecabtagene Vicleucel Toxicity in Relapsed and Refractory Multiple Myeloma Patients: Real-World Experience from the US Myeloma Immunotherapy Consortium
Published in Blood (02-11-2023)“…Background. Idecabtagene vicleucel (ide-cel) is an anti-B-cell maturation antigen (BCMA) CAR-T associated with durable responses in relapsed/refractory…”
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Safety and Efficacy of Standard of Care Ciltacabtagene Autoleucel for Relapsed/Refractory Multiple Myeloma
Published in Blood (04-10-2024)“…Ciltacabtagene autoleucel (cilta-cel) CAR-T therapy was approved in 2022 for patients with relapsed/refractory multiple myeloma (RRMM). We report outcomes with…”
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Idecabtagene Vicleucel Chimeric Antigen Receptor T-Cell Therapy for Relapsed/Refractory Multiple Myeloma with Renal Insufficiency: Real World Experience
Published in Blood (15-11-2022)Get full text
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Early cytopenias and infections after standard of care idecabtagene vicleucel in relapsed or refractory multiple myeloma
Published in Blood advances (27-12-2022)“…•Grade ≥ 3 cytopenias were at their worst at day 7 after ide-cel (94% of patients) but persisted in 40% at day 90, particularly thrombocytopenia.•Infections…”
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Immune Reconstitution and Infectious Complications Following BCMA-Targeted CAR-T Therapy in Relapsed/Refractory Multiple Myeloma (RRMM)
Published in Transplantation and cellular therapy (01-02-2024)“…Although BCMA-targeted CAR-T therapy has demonstrated efficacy in RRMM, prolonged immunosuppression and infectious complications result in significant…”
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Clinical outcomes after idecabtagene vicleucel in older patients with multiple myeloma: a multicenter real-world experience
Published in Blood advances (10-09-2024)“…•The safety and efficacy benefits of ide-cel were proportionate in young and older patients despite frailty and geriatric characteristics.•Treatment with…”
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Abstract 5707: Tumor and immune determinants of response to anti-BCMA CAR T-cell therapy in multiple myeloma using cell-free DNA
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract Background: Multiple myeloma (MM) is an incurable disease with a heterogenous clinical course and genomic landscape. Autologous anti-BCMA chimeric…”
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Idecabtagene Vicleucel (ide-cel) Chimeric Antigen Receptor T-Cell for Plasma Cell Leukemia (PCL): A Multicenter Experience
Published in Transplantation and cellular therapy (01-02-2024)“…Despite improvements in long-term outcomes of patients (pts) with multiple myeloma, the prognosis of pts with plasma cell leukemia (PCL) remains poor. We…”
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Absolute Lymphocyte Count and Outcomes of Multiple Myeloma Patients Treated with Idecabtagene Vicleucel: The US Myeloma Immunotherapy Consortium Real- World Experience
Published in Transplantation and cellular therapy (01-08-2024)“…•We explored the impact of ALC on the survival outcomes of myeloma patients treated with commercial idecabtagene vicleucel.•We created a new ALC profile and…”
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