Search Results - "Houwman, Joseline A."

Lysosomes nor Mice Move Forward without Borcs7 by Joshi, Urjita, Houwman, Joseline A., van der Sluijs, Peter

“…Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of…”
Get full text

Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase by Leferink, Nicole G. H., Antonyuk, Svetlana V., Houwman, Joseline A., Scrutton, Nigel S., Eady, Robert R., Hasnain, S. Samar

“…Enzyme mechanisms are often probed by structure-informed point mutations and measurement of their effects on enzymatic properties to test mechanistic…”
Get full text

Folding of proteins with a flavodoxin‐like architecture by Houwman, Joseline A., Mierlo, Carlo P. M.

“…The flavodoxin‐like fold is a protein architecture that can be traced back to the universal ancestor of the three kingdoms of life. Many proteins share this…”
Get full text

Concurrent presence of on- and off-pathway folding intermediates of apoflavodoxin at physiological ionic strength by Houwman, Joseline A, Westphal, Adrie H, Visser, Antonie J W G, Borst, Jan Willem, van Mierlo, Carlo P M

“…Flavodoxins have a protein topology that can be traced back to the universal ancestor of the three kingdoms of life. Proteins with this type of architecture…”
Get more information

The Ribosome Restrains Molten Globule Formation in Stalled Nascent Flavodoxin by Houwman, Joseline A., André, Estelle, Westphal, Adrie H., van Berkel, Willem J.H., van Mierlo, Carlo P.M.

“…Folding of proteins usually involves intermediates, of which an important type is the molten globule (MG). MGs are ensembles of interconverting conformers that…”
Get full text

Stalled flavodoxin binds its cofactor while fully exposed outside the ribosome by Houwman, Joseline A., Westphal, Adrie H., van Berkel, Willem J.H., van Mierlo, Carlo P.M.

“…Correct folding of proteins is crucial for cellular homeostasis. More than thirty percent of proteins contain one or more cofactors, but the impact of these…”
Get full text

The Ribosome Regulates Flavodoxin Folding by Houwman, Joseline A

“…During and after their translation by the ribosome, folding of polypeptides to biologically active proteins is of vital importance for all living organisms…”
Get full text