Search Results - "Houwertjes, Martin C"

Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming – The role of renal H2S-producing enzymes by Dugbartey, George J., Talaei, Fatemeh, Houwertjes, Martin C., Goris, Maaike, Epema, Anne H., Bouma, Hjalmar R., Henning, Robert H.

“…Hypothermia and rewarming produces organ injury through the production of reactive oxygen species. We previously found that dopamine prevents hypothermia and…”
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Platelet dynamics during natural and pharmacologically induced torpor and forced hypothermia by de Vrij, Edwin L, Vogelaar, Pieter C, Goris, Maaike, Houwertjes, Martin C, Herwig, Annika, Dugbartey, George J, Boerema, Ate S, Strijkstra, Arjen M, Bouma, Hjalmar R, Henning, Robert H

“…Hibernation is an energy-conserving behavior in winter characterized by two phases: torpor and arousal. During torpor, markedly reduced metabolic activity…”
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S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes by Samarska, Iryna V, Bouma, Hjalmar R, Buikema, Hendrik, Mungroop, Hubert E, Houwertjes, Martin C, Absalom, Anthony R, Epema, Anne H, Henning, Robert H

“…Cardiopulmonary bypass (CPB) may induce systemic inflammation and vascular dysfunction. Sphingosine 1-phosphate (S1P) modulates various vascular and immune…”
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Age-dependent Role of Microvascular Endothelial and Polymorphonuclear Cells in Lipopolysaccharide-induced Acute Kidney Injury by WULFERT, Francis M, MEURS, Matijs Van, KURNIATI, Neng F, JONGMAN, Rianne M, HOUWERTJES, Martin C, HEERINGA, Peter, STRUYS, Michel M. R. F, ZIJLSTRA, Jan G, MOLEMA, Grietje

“…The incidence of acute kidney injury following severe sepsis is higher in the elderly. We hypothesized that microvascular endothelium is "primed" by aging and…”
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Hemorrhagic Shock-induced Endothelial Cell Activation in a Spontaneous Breathing and a Mechanical Ventilation Hemorrhagic Shock Model Is Induced by a Proinflammatory Response and Not by Hypoxia by VAN MEURS, Matijs, WULFERT, Francis M, ZIJLSTRA, Jan G, MOLEMA, Grietje, JONGMAN, Rianne M, SCHIPPER, Martin, HOUWERTJES, Martin C, VANEKER, Michiel, SCHEFFER, Gert Jan, TEPPEMA, Luc J, AARTS, Leon P. H. J, HEERINGA, Peter

“…The interaction between neutrophils and activated endothelium is essential for the development of multiple organ dysfunction in patients with hemorrhagic shock…”
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Adjunct Nitrous Oxide Normalizes Vascular Reactivity Changes after Hemorrhagic Shock in Mice under Isoflurane Anesthesia by SAMARSKA, Iryna V, VAN MEURS, Matijs, BUIKEMA, Hendrik, HOUWERTJES, Martin C, WULFERT, Francis M, MOLEMA, Grietje, EPEMA, Anne H, HENNING, Robert H

“…Hemorrhagic shock is associated with changes in vascular responsiveness that may lead to organ dysfunction and, ultimately, multiple organ dysfunction…”
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The 6-hydroxychromanol derivative SUL-109 ameliorates renal injury after deep hypothermia and rewarming in rats by Vogelaar, Pieter C, Roorda, Maurits, de Vrij, Edwin L, Houwertjes, Martin C, Goris, Maaike, Bouma, Hjalmar, van der Graaf, Adrianus C, Krenning, Guido, Henning, Robert H

“…Mitochondrial dysfunction plays an important role in kidney damage in various pathologies, including acute and chronic kidney injury and diabetic nephropathy…”
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Novel Approach to Repeated Arterial Blood Sampling in Small Animal PET: Application in a Test-Retest Study with the Adenosine A1 Receptor Ligand [11C]MPDX by Sijbesma, Jürgen W. A., Zhou, Xiaoyun, Vállez García, David, Houwertjes, Martin C., Doorduin, Janine, Kwizera, Chantal, Maas, Bram, Meerlo, Peter, Dierckx, Rudi A., Slart, Riemer H. J. A., Elsinga, Philip H., van Waarde, Aren

“…Purpose Small animal positron emission tomography (PET) can be used to detect small changes in neuroreceptor availability. This often requires rapid arterial…”
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Troubleshooting the rat model of cardiopulmonary bypass: Effects of avoiding blood transfusion on long-term survival, inflammation and organ damage by Samarska, Iryna V., Henning, Robert H., Buikema, Hendrik, Bouma, Hjalmar R., Houwertjes, Martin C., Mungroop, Hubert, Struys, Michel M.R.F., Absalom, Anthony R., Epema, Anne H.

“…Rat models of cardiopulmonary bypass (CPB) have been used to examine the mechanisms of associated organ damage and to test intervention strategies. However,…”
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Microarray analysis of gene expression profiles in the rat kidney demonstrates a local inflammatory response induced by cardiopulmonary bypass by Bouma, Hjalmar R, Samarska, Iryna V, Schenk, Maria, Dahlem, Kilian K.K, van den Bos, Hilda, Brebenel, Ioan, Duin, Marry, Houwertjes, Martin C, Loef, Bertus G, Mungroop, Hubert E, Struys, Michel M.R.F, Epema, Anne H, Henning, Robert H

“…CONTEXTCardiopulmonary bypass (CPB) is a commonly used technique in cardiac surgery but is associated with acute, transient, renal dysfunction that has a…”
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Pharmacokinetic-pharmacodynamic modeling of rocuronium in case of a decreased number of acetylcholine receptors: A study in myasthenic pigs by DE HAES, Ann, PROOST, Johannes H, DE BAETS, Mark H, STASSEN, Maurice H. W, HOUWERTJES, Martin C, WIERDA, J. Mark K. H

“…In myasthenic patients, the sensitivity for nondepolarizing relaxants is increased and the time course of effect is prolonged due to a reduced number of…”
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An isolated, antegrade, perfused, peroneal nerve anterior tibialis muscle model in the rat: A novel model developed to study the factors governing the time course of action of neuromuscular blocking agents by DE HAES, Ann, HOUWERTJES, Martin C, PROOST, Johannes H, WIERDA, J. Mark K. H

“…A model of an antegrade, perfused, isolated rat peroneal nerve anterior tibial muscle was developed to study potentially important factors governing the time…”
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Structure-pharmacokinetics relationship of series of aminosteroidal neuromuscular blocking agents in the cat by Proost, J H, Wierda, J M, Houwertjes, M C, Roggeveld, J, Meijer, D K

“…To obtain more insight in the relationship between physicochemical properties of neuromuscular blocking agents (NMBAs) and their pharmacokinetic…”
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The pulmonary first-pass uptake of five nondepolarizing muscle relaxants in the pig by BEAUFORT, T. M, PROOST, J. H, HOUWERTJES, M. C, ROGGEVELD, J, WIERDA, J. M. K. H

“…It is not known whether the lungs influence the early pharmacokinetics of muscle relaxants and, if they do, whether differences in pulmonary uptake contribute…”
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S1P.sub.1 Receptor Modulation Preserves Vascular Function in Mesenteric and Coronary Arteries after CPB in the Rat Independent of Depletion of Lymphocytes by Samarska, Iryna V, Bouma, Hjalmar R, Buikema, Hendrik, Mungroop, Hubert E, Houwertjes, Martin C, Absalom, Anthony R, Epema, Anne H, Henning, Robert H

“…Background Cardiopulmonary bypass (CPB) may induce systemic inflammation and vascular dysfunction. Sphingosine 1-phosphate (S1P) modulates various vascular and…”
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Do plasma concentrations obtained from early arterial blood sampling improve pharmacokinetic/pharmacodynamic modeling? by Beaufort, T M, Proost, J H, Kuizenga, K, Houwertjes, M C, Kleef, U W, Wierda, J M

“…In pharmacokinetic/pharmacodynamic (PK/PD) modeling the first blood sample is usually taken 1 to 2 min after drug administration (late sampling). Therefore,…”
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S1P1 Receptor Modulation Preserves Vascular Function in Mesenteric and Coronary Arteries after CPB in the Rat Independent of Depletion of Lymphocytes: e97196 by Samarska, Iryna V, Bouma, Hjalmar R, Buikema, Hendrik, Mungroop, Hubert E, Houwertjes, Martin C, Absalom, Anthony R, Epema, Anne H, Henning, Robert H

“…Background Cardiopulmonary bypass (CPB) may induce systemic inflammation and vascular dysfunction. Sphingosine 1-phosphate (S1P) modulates various vascular and…”
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An Isolated, Antegrade, Perfused, Peroneal Nerve Anterior Tibialis Muscle Model in the Rat by De Haes, Ann, Houwertjes, Martin C., Proost, Johannes H., Wierda, J. Mark K. H.

“…Background A model of an antegrade, perfused, isolated rat peroneal nerve anterior tibial muscle was developed to study potentially important factors governing…”
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Pharmacokinetic–Pharmacodynamic Modeling of Rocuronium in Case of a Decreased Number of Acetylcholine Receptors by De Haes, Ann, Proost, Johannes H., De Baets, Mark H., Stassen, Maurice H. W., Houwertjes, Martin C., Wierda, J. Mark K. H.

“…Background In myasthenic patients, the sensitivity for nondepolarizing relaxants is increased and the time course of effect is prolonged due to a reduced…”
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Inhibition of the enzymic degradation of suxamethonium and mivacurium increases the onset time of submaximal neuromuscular block by BEAUFORT, T. M, NIGROVIC, V, PROOST, J. H, HOUWERTJES, M. C, WIERDA, J. M. K. H

“…The factors that influence the onset time of submaximal (<100%) neuromuscular block are not fully known. The authors hypothesized that differences in the rate…”
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