Search Results - "Houtkooper, R."

Cardiolipin, the heart of mitochondrial metabolism by Houtkooper, R. H, Vaz, F. M

“…Cardiolipin is a unique phospholipid, which is almost exclusively localized in the mitochondrial inner membrane where it is synthesized from…”
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Endothelial tip cells in vitro are less glycolytic and have a more flexible response to metabolic stress than non-tip cells by Yetkin-Arik, B., Vogels, I. M. C., Neyazi, N., van Duinen, V., Houtkooper, R. H., van Noorden, C. J. F., Klaassen, I., Schlingemann, R. O.

“…Formation of new blood vessels by differentiated endothelial tip cells, stalk cells, and phalanx cells during angiogenesis is an energy-demanding process. How…”
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NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults by Connell, N J, Grevendonk, L, Fealy, C E, Moonen-Kornips, E, Bruls, Y M H, Schrauwen-Hinderling, V B, de Vogel, J, Hageman, R, Geurts, J, Zapata-Perez, R, Houtkooper, R H, Havekes, B, Hoeks, J, Schrauwen, P

“…Boosting NAD+ via supplementation with niacin equivalents has been proposed as a potential modality capable of promoting healthy aging and negating…”
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BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane by Schug, Z T, Gonzalvez, F, Houtkooper, R H, Vaz, F M, Gottlieb, E

“…Caspase-8 stably inserts into the mitochondrial outer membrane during extrinsic apoptosis. Inhibition of caspase-8 enrichment on the mitochondria impairs…”
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mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin by Ramirez-Moral, I., Yu, X., Butler, J. M., van Weeghel, M., Otto, N. A., Ferreira, B. Lima, Maele, L. Van, Sirard, J. C., de Vos, A. F., de Jong, M. D., Houtkooper, R. H., van der Poll, T.

“…Human bronchial epithelial (HBE) cells play an essential role during bacterial infections of the airways by sensing pathogens and orchestrating protective…”
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Only One Splice Variant of the Human TAZ Gene Encodes a Functional Protein with a Role in Cardiolipin Metabolism by Vaz, Frédéric M., Houtkooper, Riekelt H., Valianpour, Fredoen, Barth, Peter G., Wanders, Ronald J.A.

“…Barth syndrome (BTHS) is an X-linked recessive disorder caused by mutations in the TAZ gene and is characterized by cardiomyopathy, short stature, neutropenia,…”
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Le sommeil in vitro : des neurones corticaux en culture révèlent des caractéristiques clés du sommeil et de l’éveil by Hinard, V, Mikhail, C, Houtkooper, R, Auwerx, J, Tafti, M

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Metabolomics to characterise adaptations in cellular metabolism for the stages of atrial fibrillation by Wijdeveld, L F J M, Pool, L, Van Weeghel, M, Schomakers, B V, De Groot, N M S, Houtkooper, R H, Brundel, B J J M

“…Abstract Background Atrial fibrillation (AF) is a highly prevalent, progressive cardiac arrhythmia associated with high cardiovascular comorbidity. Current…”
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Altered lipid metabolism in synovial fibroblasts of individuals at risk of developing rheumatoid arthritis by de Jong, T.A., Semmelink, J.F., Denis, S.W., van de Sande, M.G.H., Houtkooper, R.H.L., van Baarsen, L.G.M.

“…Fibroblast-like synoviocytes (FLS) can augment the inflammatory process observed in synovium of patients with rheumatoid arthritis (RA). A recent…”
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A single day of high fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice by Modder, M., Kuipers, E.N., Held, N.M., Het Panhuis, W. In, Ruppert, P.M.M., Kersten, S., Kooijman, S., Guisas, B., Houtkooper, R., Rensen, P., Boon, M.

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Residual inflammatory risk increases endothelial metabolism, thereby facilitating sustained vascular inflammation and leukocyte extravasation by Hanford, K.M.L., Schnitzler, J.G., Hoogeveen, R.M., Ali, K., Prange, K.H.M., Weeghel, M.V., Versloot, M., Waissi, F., Houtkooper, R., De Kleijn, D.P.V., De Winther, M., Koschinsky, M.L., Tsimikas, S., Witztum, J.L., Stroes, E.S.G., Kroon, J.

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Atherogenic lipoprotein(A) increases vascular glycolysis, thereby facilitating inflammation and leukocyte extravasation by Schnitzler, J.G., Hoogeveen, R.M., Ali, L., Prange, K., Weeghel, M.V., Versloot, M., Waissi, F., Houtkooper, R., De Kleijn, D.P.V., De Winther, M., Koschinsky, M., Tsimikas, S., Witztum, J.L., Stroes, E., Kroon, J.

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Mutations in LPIN1 Cause Recurrent Acute Myoglobinuria in Childhood by Zeharia, Avraham, Shaag, Avraham, Houtkooper, Riekelt H., Hindi, Tareq, de Lonlay, Pascale, Erez, Gilli, Hubert, Laurence, Saada, Ann, de Keyzer, Yves, Eshel, Gideon, Vaz, Frédéric M., Pines, Ophry, Elpeleg, Orly

“…Recurrent episodes of life-threatening myoglobinuria in childhood are caused by inborn errors of glycogenolysis, mitochondrial fatty acid beta-oxidation, and…”
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Mitochondrial fission: firing up mitochondria in brown adipose tissue by Gao, Arwen W, Houtkooper, Riekelt H

“…Brown adipose tissue (BAT) is an important site for energy expenditure, for instance to generate heat in times of cold exposure. BAT expansion and activation…”
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The Effect Of Mirabegron On Energy Expenditure, Brown Adipose Tissue And The Lipidomic Profile In Healthy Lean South Asian And White Caucasian Men by Martinez-Tellez, B., Nahon, K.J., Janssen, L.G.M., Sardjoe-Mishre, A.S., van Weeghel, M., Vaz, F.M., Houtkooper, R., Burakiewicz, J., Dzyubachyk, O., Kooijman, S., Webb, A.G., Kan, H.E., Berbée, J.F.P., Jazet, I.M., Boon, M., Rensen, P.C.N.

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Targeting Lipoprotein(A)-Induced Endothelial Cell Metabolic Reprogramming Reverses Inflammation And Leukocyte Migration by Schnitzler, J., Hoogeveen, R., Ali, L., Prange, K., Van Weeghel, M., Bachmann, J., Versloot, M., Houtkooper, R., Tsimikas, S., Koschinksky, M., De Winther, M., Groen, A., Stroes, E., Kroon, J.

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NAD depletion and mitochondrial protein hyperacetylation: New insights on liver toxicity and drug-induced effects in vivo by Moedas, M., Van Chruchten, A., IJlst, L., Castro, R., Houtkooper, R.H., Wanders, R.J.A., Silva, M.F.B.

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Energy Balance at a Crossroads: Translating the Science into Action by Manore, Melinda M., PhD, RD, CSSD, FACSM, Brown, Katie, EdD, RD, Houtkooper, Linda, PhD, RD, FACSM, Jakicic, John M., PhD, Peters, John C., PhD, Smith Edge, Marianne, MS, RD, LD, FADA, Steiber, Alison, PhD, RD, LD, Going, Scott, PhD, Guillermin Gable, Lisa, MA, Krautheim, Ann Marie, MS, RD

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