Search Results - "Hout, David R"

The Host Proteins Transportin SR2/TNPO3 and Cyclophilin A Exert Opposing Effects on HIV-1 Uncoating by Shah, Vaibhav B, Shi, Jiong, Hout, David R, Oztop, Ilker, Krishnan, Lavanya, Ahn, Jinwoo, Shotwell, Matthew S, Engelman, Alan, Aiken, Christopher

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Identification of triple-negative breast cancer cell lines classified under the same molecular subtype using different molecular characterization techniques: Implications for translational research by Espinosa Fernandez, Jose Rodrigo, Eckhardt, Bedrich L, Lee, Jangsoon, Lim, Bora, Pearson, Troy, Seitz, Rob S, Hout, David R, Schweitzer, Brock L, Nielsen, Tyler J, Lawrence, O Rayne, Wang, Ying, Rao, Arvind, Ueno, Naoto T

“…The original algorithm that classified triple-negative breast cancer (TNBC) into six subtypes has recently been revised. The revised algorithm (TNBCtype-IM)…”
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Rates of immune cell infiltration in patients with triple-negative breast cancer by molecular subtype by Harano, Kenichi, Wang, Ying, Lim, Bora, Seitz, Robert S, Morris, Stephan W, Bailey, Daniel B, Hout, David R, Skelton, Rachel L, Ring, Brian Z, Masuda, Hiroko, Rao, Arvind U K, Laere, Steven Van, Bertucci, Francois, Woodward, Wendy A, Reuben, James M, Krishnamurthy, Savitri, Ueno, Naoto T

“…In patients with triple-negative breast cancer (TNBC), tumor-infiltrating lymphocytes (TILs) are associated with improved survival. Lehmann et al. identified 4…”
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Association of a novel 27-gene immuno-oncology assay with efficacy of immune checkpoint inhibitors in advanced non-small cell lung cancer by Ranganath, Harsha, Jain, Amit L, Smith, Justin R, Ryder, Julie, Chaudry, Amina, Miller, Emily, Hare, Felicia, Valasareddy, Poojitha, Seitz, Robert S, Hout, David R, Varga, Matthew G, Schweitzer, Brock L, Nielsen, Tyler J, Mullins, Janice, Ross, Douglas T, Gandara, David R, Vidal, Gregory A

“…Immune checkpoint inhibitor (ICI) therapies represent a major advance in treating a variety of advanced-stage malignancies. Nevertheless, only a subset of…”
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Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue by Jovanović, Bojana, Sheng, Quanhu, Seitz, Robert S, Lawrence, Kasey D, Morris, Stephan W, Thomas, Lance R, Hout, David R, Schweitzer, Brock L, Guo, Yan, Pietenpol, Jennifer A, Lehmann, Brian D

“…Triple negative breast cancer (TNBC) is a heterogeneous disease that lacks unifying molecular alterations that can guide therapy decisions. We previously…”
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A novel immuno-oncology algorithm measuring tumor microenvironment to predict response to immunotherapies by Nielsen, Tyler J., Ring, Brian Z., Seitz, Robert S., Hout, David R., Schweitzer, Brock L.

“…Immune checkpoint inhibitor (ICI) therapies can improve clinical outcomes for patients with solid tumors, but relatively few patients respond. Because ICI…”
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Characterization of the tumor immune-microenvironment of adenocarcinoma of lung with a metastatic lesion in the pancreas treated successfully with first-line, single-agent pembrolizumab by Saltman, David L., Nielsen, Tyler J., Salina, Davide, Hout, David R., McMahon, Frank B., Valev, Boris R., Huk, Michael, Chandra, Pranil K., Spille, Jeremy, Seitz, Robert S., Schweitzer, Brock L.

“…Single-agent immune checkpoint inhibitor therapy in advanced non-small cell lung cancer can significantly prolong progression-free and overall survival when…”
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Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients by Ring, Brian Z, Hout, David R, Morris, Stephan W, Lawrence, Kasey, Schweitzer, Brock L, Bailey, Daniel B, Lehmann, Brian D, Pietenpol, Jennifer A, Seitz, Robert S

“…Recently, a gene expression algorithm, TNBCtype, was developed that can divide triple-negative breast cancer (TNBC) into molecularly-defined subtypes. The…”
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27-gene Immuno-Oncology (IO) Score is Associated With Efficacy of Checkpoint Immunotherapy in Advanced NSCLC: A Retrospective BC Cancer Study by Saltman, David L., Varga, Matthew G., Nielsen, Tyler J., Croteau, Nicole S., Lockyer, Heather M., Jain, Amit L., Vidal, Gregory A., Hout, David R., Schweitzer, Brock L., Seitz, Robert S., Ross, Douglas T., Gandara, David R.

“…Immune checkpoint inhibitors (ICI) are standard of care in advanced non-small cell lung cancer (NSCLC). However, not all patients benefit, even among PD-L1…”
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Changes in Triple-Negative Breast Cancer Molecular Subtypes in Patients Without Pathologic Complete Response After Neoadjuvant Systemic Chemotherapy by Masuda, Hiroko, Harano, Kenichi, Miura, Sakiko, Wang, Ying, Hirota, Yuko, Harada, Oi, Jolly, Mohit Kumar, Matsunaga, Yuki, Lim, Bora, Wood, Anita L, Parinyanitikul, Napa, Jin Lee, Hee, Gong, Gyungyub, George, Jason T, Levine, Herbert, Lee, Jangsoon, Wang, Xiaoping, Lucci, Anthony, Rao, Arvind, Schweitzer, Brock L, Lawrence, O Rayne, Seitz, Robert S, Morris, Stephan W, Hout, David R, Nakamura, Seigo, Krishnamurthy, Savitri, Ueno, Naoto T

“…Lehmann et al have identified four molecular subtypes of triple-negative breast cancer (TNBC)-basal-like (BL) 1, BL2, mesenchymal (M), and luminal androgen…”
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Performance of a RT-PCR Assay in Comparison to FISH and Immunohistochemistry for the Detection of ALK in Non-Small Cell Lung Cancer by Hout, David R, Schweitzer, Brock L, Lawrence, Kasey, Morris, Stephan W, Tucker, Tracy, Mazzola, Rosetta, Skelton, Rachel, McMahon, Frank, Handshoe, John, Lesperance, Mary, Karsan, Aly, Saltman, David L

“…Patients with lung cancers harboring an activating anaplastic lymphoma kinase ( ) rearrangement respond favorably to ALK inhibitor therapy. Fluorescence in…”
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Erratum to: Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients by Ring, Brian Z, Hout, David R, Morris, Stephan W, Lawrence, Kasey, Schweitzer, Brock L, Bailey, Daniel B, Lehmann, Brian D, Pietenpol, Jennifer A, Seitz, Robert S

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Routine Screening for Triple-Negative Adenocarcinoma (TNA) Lung Cancer Patients: A New Hope for a Poor-Prognosis Population by Handshoe, John M., Skelton, Rachel L., Lawrence, Kasey D., Chatfield, Lindsay E., Morris, Stephan W., Hout, David R., Schweitzer, Brock L.

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A single amino acid substitution within the transmembrane domain of the human immunodeficiency virus type 1 Vpu protein renders simian–human immunodeficiency virus (SHIV KU-1bMC33) susceptible to rimantadine by Hout, David R., Gomez, Lisa M., Pacyniak, Erik, Miller, Jean-Marie, Hill, M. Sarah, Stephens, Edward B.

“…Previous studies from our laboratory have shown that the transmembrane domain (TM) of the Vpu protein of human immunodeficiency virus type 1 (HIV-1)…”
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Identification of a region within the cytoplasmic domain of the subtype B Vpu protein of human immunodeficiency virus type 1 (HIV-1) that is responsible for retention in the golgi complex and its absence in the Vpu protein from a subtype C HIV-1 by Pacyniak, Erik, Gomez, Melissa L, Gomez, Lisa M, Mulcahy, Ellyn R, Jackson, Mollie, Hout, David R, Wisdom, Billie J, Stephens, Edward B

“…The structure of the Vpu protein of human immunodeficiency virus type 1 (HIV-1) is composed of a short Nterminal domain (NTD), a transmembrane domain (TM), and…”
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Scrambling of the amino acids within the transmembrane domain of Vpu results in a simian-human immunodeficiency virus (SHIV TM) that is less pathogenic for pig-tailed macaques by Hout, David R., Gomez, Melissa L., Pacyniak, Erik, Gomez, Lisa M., Inbody, Sarah H., Mulcahy, Ellyn R., Culley, Nathan, Pinson, David M., Powers, Michael F., Wong, Scott W., Stephens, Edward B.

“…Previous studies have shown that the transmembrane (TM) domain of the subtype B Vpu enhances virion release from cells and some studies have shown that this…”
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Substitution of the transmembrane domain of Vpu in simian–human immunodeficiency virus (SHIV KU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques by Hout, David R., Gomez, Melissa L., Pacyniak, Erik, Gomez, Lisa M., Fegley, Barbara, Mulcahy, Ellyn R., Hill, M. Sarah, Culley, Nathan, Pinson, David M., Nothnick, Warren, Powers, Michael F., Wong, Scott W., Stephens, Edward B.

“…The Vpu protein of human immunodeficiency virus type 1 has been shown to shunt the CD4 receptor molecule to the proteasome for degradation and to enhance virus…”
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The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4+ T cell loss caused by the simian–human immunodeficiency virus SHIVKU-lbMC33 in pig-tailed macaques by Singh, Dinesh K, Griffin, Darcy M, Pacyniak, Erik, Jackson, Mollie, Werle, Michael J, Wisdom, Bo, Sun, Francis, Hout, David R, Pinson, David M, Gunderson, Robert S, Powers, Michael F, Wong, Scott W, Stephens, Edward B

“…The simian–human immunodeficiency virus (SHIV)/ macaque model for human immunodeficiency virus type 1 has become a useful tool to assess the role of Vpu in…”
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Abstract 23: Validation of a 27-gene immuno-oncology algorithm in metastatic urothelial carcinoma treated with an immune checkpoint inhibitor by Seitz, Robert S., Ross, Douglas T., Nielsen, Tyler J., Hout, David R., Schweitzer, Brock L.

“…Abstract Background Prognosis for patients with metastatic urothelial carcinoma (mUC) remains poor with fewer than 10% of patients surviving two years after…”
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Abstract 175: Pathway modeling to translate the 27-gene immuno-oncology algorithm into bladder cancer by Seitz, Robert S., Nielsen, Tyler J., Schweitzer, Brock L., Hout, David R., Ross, Douglas T.

“…Abstract Background The 27-gene immuno-oncology (IO) algorithm has demonstrated an association with immune checkpoint inhibitor (ICI) response in TNBC, NSCLC,…”
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