Search Results - "Houston, Todd A."

Rational Design and Synthesis of Methyl-β-d-galactomalonyl Phenyl Esters as Potent Galectin-8 N Antagonists by Patel, Brijesh, Kishor, Chandan, Houston, Todd A, Shatz-Azoulay, Hadas, Zick, Yehiel, Vinik, Yaron, Blanchard, Helen

“…Galectin-8 is a β-galactoside-recognizing protein having an important role in the regulation of bone remodeling and cancer progression and metastasis. Methyl…”
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Rational Design and Synthesis of Methyl-β‑d‑galactomalonyl Phenyl Esters as Potent Galectin‑8N Antagonists by Patel, Brijesh, Kishor, Chandan, Houston, Todd. A, Shatz-Azoulay, Hadas, Zick, Yehiel, Vinik, Yaron, Blanchard, Helen

“…Galectin-8 is a β-galactoside-recognizing protein having an important role in the regulation of bone remodeling and cancer progression and metastasis. Methyl…”
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Multisite Modification of Neomycin B:  Combined Mitsunobu and Click Chemistry Approach by Quader, Sabina, Boyd, Sue E, Jenkins, Ian D, Houston, Todd A

“…The aminoglycoside antibiotic neomycin B has been converted into several novel building blocks that can be used for the specific modification of three of the…”
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Carbohydrate-based nanocarriers and their application to target macrophages and deliver antimicrobial agents by Mosaiab, Tamim, Farr, Dylan C., Kiefel, Milton J., Houston, Todd A.

“…Many deadly infections are produced by microorganisms capable of sustained survival in macrophages. This reduces exposure to chemadrotherapy, prevents immune…”
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Synthesis of 1‑Deoxymannojirimycin from d‑Fructose using the Mitsunobu Reaction by Sunde-Brown, Peter, Jenkins, Ian D., Houston, Todd A.

“…Three different Mitsunobu reactions have been investigated for the synthesis of 1-deoxymannojirimycin (1-DMJ) from d-fructose. The highest yielding and most…”
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Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency by Simone, Michela I., Wood, Adam, Campkin, David, Kiefel, Milton J., Houston, Todd A.

“…This review covers the literature in the past 15 years on glycosidase inhibitors lacking a basic nitrogen (for example iminosugars/azasugars) with a focus on…”
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Reassessing the putative molecular Target(s) of potent antitubercular 2-(Alkylsulfonyl)acetamides by Farr, Dylan C, Haselhorst, Thomas, Tan, Lendl, Furness, Juanelle, Strong, Emily, Grice, I Darren, West, Nicholas P, Houston, Todd A

“…Simple alkyl-sulfonylacetamides have potent antitubercular activity and significantly decrease mycolic acid levels in mycobacteria. Although these compounds…”
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Synthesis and antibacterial activity of 6″-decanesulfonylacetamide-functionalised amphiphilic derivatives of amikacin and kanamycin by Farr, Dylan C, Tan, Lendl, Furness, Juanelle, Grice, I Darren, West, Nicholas P, Houston, Todd A

“…Aminoglycoside antibiotics represent the first class of successful drugs in the treatment of tuberculosis; however, mycobacteria and other bacterial species…”
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Synthetic Routes to 3,4,5‐Trihydroxypiperidines via Stereoselective and Biocatalysed Protocols, and Strategies to N‐ and O‐Derivatisation by Prichard, Kate L., O'Brien, Nicholas, Ghorbani, Mahdi, Wood, Adam, Barnes, Evan, Kato, Atsushi, Houston, Todd A., Simone, Michela I.

“…Stereoselective and biocatalysed synthetic routes to 3,4,5‐trihydroxypiperidines and their N‐ and O‐derivatisations are reviewed. These iminosugars effectively…”
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Synthetic Pathways to 3,4,5‐Trihydroxypiperidines from the Chiral Pool by Wood, Adam, Prichard, Kate L., Clarke, Zane, Houston, Todd A., Fleet, George W. J., Simone, Michela I.

“…3,4,5‐Trihydroxypiperidines represent a family of biologically active natural products, found to modulate principally the glycosidase enzymes. This is ascribed…”
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Carbonic Anhydrase Inhibitors:  Inhibition of Isozymes I, II, and IX with Triazole-Linked O-Glycosides of Benzene Sulfonamides by Wilkinson, Brendan L, Bornaghi, Laurent F, Houston, Todd A, Innocenti, Alessio, Vullo, Daniela, Supuran, Claudiu T, Poulsen, Sally-Ann

“…We report the synthesis of a series of benzene sulfonamides containing triazole-O-glycoside tails for evaluation as carbonic anhydrase (CA) inhibitors. These…”
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A Novel Class of Carbonic Anhydrase Inhibitors:  Glycoconjugate Benzene Sulfonamides Prepared by “Click-Tailing” by Wilkinson, Brendan L, Bornaghi, Laurent F, Houston, Todd A, Innocenti, Alessio, Supuran, Claudiu T, Poulsen, Sally-Ann

“…Aryl and heteroaryl sulfonamides (ArSO2NH2) are therapeutically used to inhibit the catalytic activity of carbonic anhydrases (CAs). Using a “click-tail”…”
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Developing High-Affinity Boron-Based Receptors for Cell-Surface Carbohydrates by Houston, Todd A

“…The rich history of research into boron–carbohydrate interactions has, unfortunately, not translated into many examples of boron‐based receptors for…”
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Synthetic utility of glycosyl triazoles in carbohydrate chemistry by Wilkinson, Brendan L., Bornaghi, Laurent F., Poulsen, Sally-Ann, Houston, Todd A.

“…We report herein a study of the synthetic utility of the glucosyl triazole moiety in carbohydrate chemistry. A model glucosyl triazole was prepared by a…”
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A Simple Glycolipid Mimic of the Phosphatidylinositol Mannoside Core from Mycobacterium tuberculosis Inhibits Macrophage Cytokine Production by Mosaiab, Tamim, Boiteux, Sandra, Zulfiker, Abu Hasanat Md, Wei, Ming Q., Kiefel, Milton J., Houston, Todd A.

“…Glycolipids from Mycobacterium tuberculosis have a profound impact on the innate immune response of the host. Macrophage‐inducible C‐type lectin (Mincle) is a…”
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Redox state influence on human galectin-1 function by Yu, Xing, Scott, Stacy A., Pritchard, Rhys, Houston, Todd A., Ralph, Stephen J., Blanchard, Helen

“…Intracellular and extracellular functions of human galectin-1 are influenced by its redox surroundings due to the presence of six cysteines within its amino…”
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Direct Mitsunobu monoesterification of N-protected tobramycin competes with intramolecular pyrrolidine formation in ester prodrug synthesis by Quader, Sabina, Boyd, Sue E., Jenkins, Ian D., Houston, Todd A.

“…Unlike the related aminoglycoside neomycin B, N-protected tobramycin can be selectively esterified at its sole, primary hydroxyl group under Mitsunobu…”
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Boronolectin with divergent fluorescent response specific for free sialic acid by Levonis, Stephan M, Kiefel, Milton J, Houston, Todd A

“…A fluorescent boronate receptor with a unique response to free sialic acid has been developed; this divergent response system may find use in design of other…”
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Squalamine and its derivatives as potential antitubercular compounds by Walker, Brian T, Houston, Todd A

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3α-Azido-5-cholestene by Houston, Todd A, Quader, Sabina, Boyd, Sue E, Jenkins, Ian D, Healy, Peter C

“…The crystal structure of the title compound, C(27)H(45)N(3), has been determined as part of our investigation into the hydro-phobic modification of…”
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