Search Results - "Housley, Nicole"

Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function by Audia, Jonathon P., Yang, Xi-Ming, Crockett, Edward S., Housley, Nicole, Haq, Ehtesham Ul, O’Donnell, Kristen, Cohen, Michael V., Downey, James M., Alvarez, Diego F.

“…Patients with acute myocardial infarction receive a P2Y 12 receptor antagonist prior to reperfusion, a treatment that has reduced, but not eliminated,…”
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The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model by Hardy, Kierra S, Tuckey, Amanda N, Housley, Nicole A, Andrews, Joel, Patel, Mita, Al-Mehdi, Abu-Bakr, Barrington, Robert A, Cassel, Suzanne L, Sutterwala, Fayyaz S, Audia, Jonathon P

“…Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark of P…”
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In the absence of effector proteins, the Pseudomonas aeruginosa type three secretion system needle tip complex contributes to lung injury and systemic inflammatory responses by Audia, Jonathon P, Lindsey, Ashley S, Housley, Nicole A, Ochoa, Courtney R, Zhou, Chun, Toba, Michie, Oka, Masahiko, Annamdevula, Naga S, Fitzgerald, Meshann S, Frank, Dara W, Alvarez, Diego F

“…Herein we describe a pathogenic role for the Pseudomonas aeruginosa type three secretion system (T3SS) needle tip complex protein, PcrV, in causing lung…”
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The Highly Selective Caspase-1 Inhibitor VX-765 Provides Additive Protection Against Myocardial Infarction in Rat Hearts When Combined With a Platelet Inhibitor by Yang, Xi-Ming, Downey, James M, Cohen, Michael V, Housley, Nicole A, Alvarez, Diego F, Audia, Jonathon P

“…Use of ischemic postconditioning and other related cardioprotective interventions to treat patients with acute myocardial infarction (AMI) has failed to…”
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Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents by Helgren, Travis R., Chen, Congling, Wangtrakuldee, Phumvadee, Edwards, Thomas E., Staker, Bart L., Abendroth, Jan, Sankaran, Banumathi, Housley, Nicole A., Myler, Peter J., Audia, Jonathon P., Horn, James R., Hagen, Timothy J.

“…[Display omitted] Methionine aminopeptidase (MetAP) is a class of ubiquitous enzymes essential for the survival of numerous bacterial species. These enzymes…”
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Analysis of pulmonary vascular injury and repair during Pseudomonas aeruginosa infection-induced pneumonia and acute respiratory distress syndrome by Lindsey, Ashley S., Sullivan, Lydia M., Housley, Nicole A., Koloteva, Anna, King, Judy A., Audia, Jonathon P., Alvarez, Diego F.

“…Herein we describe lung vascular injury and repair using a rodent model of Pseudomonas aeruginosa pneumonia-induced acute respiratory distress syndrome (ARDS)…”
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The Rickettsia prowazekii ExoU Homologue Possesses Phospholipase A1 (PLA1), PLA2, and Lyso-PLA2 Activities and Can Function in the Absence of Any Eukaryotic Cofactors In Vitro by HOUSLEY, Nicole A, WINKLER, Herbert H, AUDIA, Jonathon P

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Rickettsia prowazekii Uses an sn-Glycerol-3-Phosphate Dehydrogenase and a Novel Dihydroxyacetone Phosphate Transport System To Supply Triose Phosphate for Phospholipid Biosynthesis by Frohlich, Kyla M, Roberts, Rosemary A W, Housley, Nicole A, Audia, Jonathon P

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Thermodynamic Stability of Domain 2 of Epithelial Cadherin by Prasad, Alka, Housley, Nicole A, Pedigo, Susan

“…Cadherin is a cell adhesion molecule that participates in ordered calcium-dependent self-association interactions both between molecules on the same cell…”
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Ligand-linked stability of mutants of the C-domain of calmodulin by Hobson, Kenosha F., Housley, Nicole A., Pedigo, Susan

“…There is a necessary energetic linkage between ligand binding and stability in biological molecules. The critical glutamate in Site 4 was mutated to create two…”
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Secreted Caspase‐1 Contracts Amyloid‐related Danger Molecules Released from Pulmonary Microvascular Endothelial Cell as a Novel Stress Response during Infection by Eslaamizaad, Yasaman, Housley, Nicole, Bell, Jessica, Audia, Jon P., Alvarez, Diego F.

“…Amyloid Beta (Aβ) are a group of peptides present in several oligomeric states that upon misfolding cause prionopathies. Emerging evidence indicates that…”
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Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions by Voth, Sarah, Gwin, Meredith, Francis, Christopher Michael, Balczon, Ron, Frank, Dara W., Pittet, Jean‐Francois, Wagener, Brant M., Moser, Stephen A., Alexeyev, Mikhail, Housley, Nicole, Audia, Jonathon P., Piechocki, Scott, Madera, Kayla, Simmons, Autumn, Crawford, Michaela, Stevens, Troy

“…Pseudomonas aeruginosa infection elicits the production of cytotoxic amyloids from lung endothelium, yet molecular mechanisms of host‐pathogen interaction that…”
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The Rickettsia prowazekii ExoU Homologue Possesses Phospholipase A 1 (PLA 1 ), PLA 2 , and Lyso-PLA 2 Activities and Can Function in the Absence of Any Eukaryotic Cofactors In Vitro by Housley, Nicole A., Winkler, Herbert H., Audia, Jonathon P.

“…ABSTRACT Here we have characterized the Rickettsia prowazekii RP534 protein, a homologue of the Pseudomonas aeruginosa ExoU phospholipase A (PLA) secreted…”
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cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection by Renema, Phoibe, Hardy, Kierra S, Housley, Nicole, Dunbar, Grace, Annamdevula, Naga, Britain, Andrea, Spadafora, Domenico, Leavesley, Silas, Rich, Thomas, Audia, Jonathon P, Alvarez, Diego F

“…Activation of the inflammasome-caspase-1 axis in lung endothelial cells is emerging as a novel arm of the innate immune response to pneumonia and sepsis caused…”
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Caspase-1 Activation Protects Lung Endothelial Barrier Function during Infection-Induced Stress by Alvarez, Diego F, Housley, Nicole, Koloteva, Anna, Zhou, Chun, O'Donnell, Kristen, Audia, Jonathon P

“…Dysregulated activation of the inflammasome-caspase-1-IL-1β axis elicits damaging hyperinflammation during critical illnesses, such as pneumonia and sepsis…”
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cAMP Potentiates Caspase‐1 Activation in Pulmonary Microvascular Endothelial Cells During Pseudomonas aeruginosa Infection by Renema, Phoibe, Housley, Nicole Ann, Audia, Jonathon Peter, Alvarez, Diego Fernando

“…Abstract only Caspase‐1 is an inflammatory protease responsible for cytokine maturation and programmed inflammatory cell death. In the lung, Pseudomonas…”
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The Rickettsia prowazekii ExoU Homologue Possesses Phospholipase A^sub 1^ (PLA^sub 1^), PLA^sub 2^, and Lyso-PLA^sub 2^ Activities and Can Function in the Absence of Any Eukaryotic Cofactors In Vitro by Housley, Nicole A, Winkler, Herbert H, Audia, Jonathon P

“…Here we have characterized the Rickettsia prowazekii RP534 protein, a homologue of the Pseudomonas aeruginosa ExoU phospholipase A (PLA) secreted cytotoxin…”
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EXPRESS: Analysis of Pulmonary Vascular Injury and Repair during Pseudomonas aeruginosa Infection-induced Pneumonia and Acute Respiratory Distress Syndrome by Lindsey, Ashley, Sullivan, Lydia, Housley, Nicole, Koloteva, Anna, King, Judy, Audia, Jonathon, Alvarez, Diego F

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Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y 12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function by Audia, Jonathon P, Yang, Xi-Ming, Crockett, Edward S, Housley, Nicole, Haq, Ehtesham Ul, O'Donnell, Kristen, Cohen, Michael V, Downey, James M, Alvarez, Diego F

“…Patients with acute myocardial infarction receive a P2Y receptor antagonist prior to reperfusion, a treatment that has reduced, but not eliminated, mortality,…”
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Rickettsia prowazekii Uses an sn-Glycerol-3-Phosphate Dehydrogenase and a Novel Dihydroxycetone Phosphate Transport System To Supply Triose Phosphate for Phospholipid Biosynthesis by FROHLICH, Kyla M, ROBERTS, Rosemary A. W, HOUSLEY, Nicole A, AUDIA, Jonathon P

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