Search Results - "Housh, Kurt"

Formation and Repair of an Interstrand DNA Cross-Link Arising from a Common Endogenous Lesion by Housh, Kurt, Jha, Jay S, Yang, Zhiyu, Haldar, Tuhin, Johnson, Kevin M, Yin, Jiekai, Wang, Yinsheng, Gates, Kent S

“…Interstrand DNA cross-links (ICLs) are cytotoxic because they block the strand separation required for read-out and replication of the genetic information in…”
Get full text

Synthesis of DNA Duplexes Containing Site-Specific Interstrand Cross-Links via Sequential Reductive Amination Reactions Involving Diamine Linkers and Abasic Sites on Complementary Oligodeoxynucleotides by Housh, Kurt, Gates, Kent S

“…Interstrand DNA cross-links are important in biology, medicinal chemistry, and materials science. Accordingly, methods for the targeted installation of…”
Get full text

Unexpected Complexity in the Products Arising from NaOH‑, Heat‑, Amine‑, and Glycosylase-Induced Strand Cleavage at an Abasic Site in DNA by Haldar, Tuhin, Jha, Jay S, Yang, Zhiyu, Nel, Christopher, Housh, Kurt, Cassidy, Orla J, Gates, Kent S

“…Hydrolytic loss of nucleobases from the deoxyribose backbone of DNA is one of the most common unavoidable types of damage in synthetic and cellular DNA. The…”
Get full text

Products Generated by Amine-Catalyzed Strand Cleavage at Apurinic/Apyrimidinic Sites in DNA: New Insights from a Biomimetic Nucleoside Model System by Jha, Jay S., Nel, Christopher, Haldar, Tuhin, Peters, Daniel, Housh, Kurt, Gates, Kent S.

“…Abasic sites are common in cellular and synthetic DNA. As a result, it is important to characterize the chemical fate of these lesions. Amine-catalyzed strand…”
Get full text

Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA by Housh, Kurt, Jha, Jay S., Haldar, Tuhin, Amin, Saosan Binth Md, Islam, Tanhaul, Wallace, Amanda, Gomina, Anuoluwapo, Guo, Xu, Nel, Christopher, Wyatt, Jesse W., Gates, Kent S.

“…Genome integrity is essential for life and, as a result, DNA repair systems evolved to remove unavoidable DNA lesions from cellular DNA. Many forms of life…”
Get full text

Unhooking of an interstrand cross-link at DNA fork structures by the DNA glycosylase NEIL3 by Imani Nejad, Maryam, Housh, Kurt, Rodriguez, Alyssa A., Haldar, Tuhin, Kathe, Scott, Wallace, Susan S., Eichman, Brandt F., Gates, Kent S.

“…[Display omitted] •This article characterizes a novel pathway for interstrand DNA cross-link (ICL) repair.•This ICL repair pathway involves the unhooking of…”
Get full text

Reactivity of Lesions Derived from Abasic (AP) Sites in DNA by Housh, Kurt L

“…DNA is vital to cellular function. Therefore, maintaining the integrity of the structure of DNA is of utmost importance. Damage to the DNA is unavoidable and…”
Get full text