Search Results - "Houseman, Kathryn"

Electrophysiologic characterization of a novel hERG channel activator by Su, Zhi, Limberis, James, Souers, Andrew, Kym, Philip, Mikhail, Ann, Houseman, Kathryn, Diaz, Gilbert, Liu, Xiaoqin, Martin, Ruth L., Cox, Bryan F., Gintant, Gary A.

“…Activators of the human ether-a-go-go-related gene (hERG) K + channel have been reported recently to enhance hERG current amplitude (five synthetic small…”
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Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease by Nagarajan, Srinivasan R, De Crescenzo, Gary A, Getman, Daniel P, Lu, Hwang-Fun, Sikorski, James A, Walker, Jeffrey L, McDonald, Joseph J, Houseman, Kathryn A, Kocan, Geralyn P, Kishore, Nandini, Mehta, Pramod P, Funkes-Shippy, Christie L, Blystone, Lisa

“…The human immunodeficiency virus (HIV) has been shown to be the causative agent for AIDS. The HIV virus encodes for a unique aspartyl protease that is…”
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1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel by Dinges, Jürgen, Albert, Daniel H, Arnold, Lee D, Ashworth, Kimba L, Akritopoulou-Zanze, Irini, Bousquet, Peter F, Bouska, Jennifer J, Cunha, George A, Davidsen, Steven K, Diaz, Gilbert J, Djuric, Stevan W, Gasiecki, Alan F, Gintant, Gary A, Gracias, Vijaya J, Harris, Christopher M, Houseman, Kathryn A, Hutchins, Charles W, Johnson, Eric F, Li, Hu, Marcotte, Patrick A, Martin, Ruth L, Michaelides, Michael R, Nyein, Michelle, Sowin, Thomas J, Su, Zhi, Tapang, Paul H, Xia, Zhiren, Zhang, Henry Q

“…The synthesis of a novel series of 1,4-dihydroindeno[1,2-c]pyrazoles with acetylene-type side chains is described. Optimization of those compounds as KDR…”
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Ventricular rate adaptation: A novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds by Green, Jonathon R., Diaz, Gilbert J., Limberis, James T., Houseman, Kathryn A., Su, Zhi, Martin, Ruth L., Cox, Bryan F., Kantor, Stan, Gintant, Gary A.

“…Delayed cardiac repolarization is an established risk factor for proarrhythmia and Torsades-de-Pointes (TdeP) that is typically measured in vitro during slow,…”
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An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists by Iyengar, Rajesh R., Lynch, John K., Mulhern, Mathew M., Judd, Andrew S., Freeman, Jennifer C., Gao, Ju, Souers, Andrew J., Zhao, Gang, Wodka, Dariusz, Doug Falls, H., Brodjian, Sevan, Dayton, Brian D., Reilly, Regina M., Swanson, Sue, Su, Zhi, Martin, Ruth L., Leitza, Sandra T., Houseman, Kathryn A., Diaz, Gilbert, Collins, Christine A., Sham, Hing L., Kym, Philip R.

“…The optimization of potent MCHr1 antagonist 1 with respect to improving its in vitro profile by replacement of the 3,4-methylenedioxy phenyl (piperonyl) moiety…”
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Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity by Judd, Andrew S., Souers, Andrew J., Wodka, Dariusz, Zhao, Gang, Mulhern, Mathew M., Iyengar, Rajesh R., Gao, Ju, Lynch, John K., Freeman, Jennifer C., Falls, H. Douglas, Brodjian, Sevan, Dayton, Brian D., Reilly, Regina M., Gintant, Gary, Limberis, James T., Mikhail, Ann, Leitza, Sandra T., Houseman, Kathryn A., Diaz, Gilbert, Bush, Eugene N., Shapiro, Robin, Knourek-Segel, Victoria, Hernandez, Lisa E., Marsh, Kennan C., Sham, Hing L., Collins, Christine A., Kym, Philip R.

“…A series of potent 2-carboxychromone-based melanin-concentrating hormone receptor 1 (MCHr1) antagonists were synthesized and evaluated for hERG (human…”
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Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere by Getman, Daniel P, DeCrescenzo, Gary A, Heintz, Robert M, Reed, Kathryn L, Talley, John J, Bryant, Martin L, Clare, Michael, Houseman, Kathryn A, Marr, J. Joseph

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Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition. Evidence for multiple binding modes by Rich, Daniel H, Sun, Chong Qing, Prasad, J. V. N. Vara, Pathiasseril, Ahammadunny, Toth, Mihaly V, Marshall, Garland R, Clare, Michael, Mueller, Richard A, Houseman, Kathryn

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Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers by Liu, Xiaoqin, Limberis, James T., Su, Zhi, Houseman, Kathryn, Diaz, Gilbert J., Gintant, Gary A., Cox, Bryan F., Martin, Ruth L.

“…In a previous study we found that A-935142 enhanced hERG current in a concentration-dependent manner by facilitating activation, reducing inactivation, and…”
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Drug-Induced hERG Current Enhancement is Modulated by Extracellular Proton and Potassium by Su, Zhi, Liu, Xiaoqin, Wu, Jian, Houseman, Kathryn, Limberis, James, Padden, Brian, Martin, Ruth L., Cox, Bryan F., Gintant, Gary A.

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Optimization of a Cav1.2 Cell Line for Use on QPatch and PatchXpress by Martin, Ruth L., Limberis, James T., Liu, Xiaoqin, Houseman, Kathryn, Su, Zhi, Niforatos, Wende, Cox, Bryan F., Gintant, Gary A.

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Inhibitors of HIV-1 Protease Containing the Novel and Potent (R)-(Hydroxyethyl)sulfonamide Isostere by Vazquez, Michael L, Bryant, Martin L, Clare, Michael, DeCrescenzo, Gary A, Doherty, Elizabeth M, Freskos, John N, Getman, Daniel P, Houseman, Kathryn A, Julien, Janet A, Kocan, Geralyn P, Mueller, Richard A, Shieh, Huey-Sheng, Stallings, William C, Stegeman, Roderick A, Tilley, John J

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Optimization of Chromone-2-carboxamide Melanin Concentrating Hormone Receptor 1 Antagonists:  Assessment of Potency, Efficacy, and Cardiovascular Safety by Lynch, John K, Freeman, Jennifer C, Judd, Andrew S, Iyengar, Rajesh, Mulhern, Mathew, Zhao, Gang, Napier, James J, Wodka, Dariusz, Brodjian, Sevan, Dayton, Brian D, Falls, Doug, Ogiela, Christopher, Reilly, Regina M, Campbell, Thomas J, Polakowski, James S, Hernandez, Lisa, Marsh, Kennan C, Shapiro, Robin, Knourek-Segel, Victoria, Droz, Brian, Bush, Eugene, Brune, Michael, Preusser, Lee C, Fryer, Ryan M, Reinhart, Glenn A, Houseman, Kathryn, Diaz, Gilbert, Mikhail, Ann, Limberis, James T, Sham, Hing L, Collins, Christine A, Kym, Philip R

“…Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in an anesthetized rat cardiovascualar assay led to…”
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Ion Channel Toolbox for Cardiac Safety Evaluation by Martin, Ruth L., Limberis, James T., Liu, Xiaoqin, Houseman, Kathryn A., Su, Zhi, Gintant, Gary A., Cox, Bryan F.

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Do hERG Enhancers and Blockers Compete? by Liu, Xiaoqin, Limberis, James T., Su, Zhi, Houseman, Kathryn A., Diaz, Gilbert J., Gintant, Gary A., Cox, Bryan F., Martin, Ruth L.

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Electrophysiologic Characterization of a Complex hERG Channel Activator by Su, Zhi, Limberis, James, Souers, Andrew, Kym, Philip, Mikhail, Ann, Houseman, Kathryn, Diaz, Gilbert, Martin, Ruth L., Cox, Bryan F., Gintant, Gary A.

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Radiation protection in vivo by prostaglandins and related compounds of the arachidonic acid cascade by Hanson, W R, Houseman, K A, Collins, P W

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The effects of mandated standardized testing on teachers' perceptions on the formation and development of professional learning communities in the schools of the Rock Valley Conference by Houseman, Kathryn

“…The staff professional development and school improvement model of the professional learning community is a powerful tool for reculturing schools from within…”
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New hydroxyethylamine HIV protease inhibitors that suppress viral replication by Rich, Daniel H, Prasad, J. V. N. Vara, Sun, Chong Qing, Green, Jeremy, Mueller, Richard, Houseman, Kathryn, MacKenzie, Debra, Malkovsky, Miroslav

“…The synthesis of analogues of AcSerLeuAsn[Phe-HEA-Pro]IleValOMe (1, JG-365; where HEA stands for the hydroxyethylamine unit 2), a tight-binding inhibitor of…”
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HIV-1 protease inhibitors: ketomethylene isosteres with unusually high affinity compared with hydroxyethylene isostere analogs by Marinier, A, Toth, M V, Houseman, K, Mueller, R, Marshall, G R

“…HIV protease is a member of the aspartic proteinase family of proteolytic enzymes which include pepsin and renin. In contrast to the enhanced affinity seen…”
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