Search Results - "Householder, Kyle T"

A critical evaluation of drug delivery from ligand modified nanoparticles: Confounding small molecule distribution and efficacy in the central nervous system by Cook, Rebecca L., Householder, Kyle T., Chung, Eugene P., Prakapenka, Alesia V., DiPerna, Danielle M., Sirianni, Rachael W.

“…In this work, we sought to test how surface modification of poly(lactic-co-glycolic acid) (PLGA) nanoparticles with peptide ligand alters the brain specific…”
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CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation by Moutal, Aubin, Villa, Lex Salas, Yeon, Seul Ki, Householder, Kyle T., Park, Ki Duk, Sirianni, Rachael W., Khanna, Rajesh

“…Glioblastoma (GBM) is an aggressive primary brain tumor. The rapid growth and the privileged provenance of the tumor within the brain contribute to its…”
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Curcumin-releasing mechanically adaptive intracortical implants improve the proximal neuronal density and blood–brain barrier stability by Potter, Kelsey A., Jorfi, Mehdi, Householder, Kyle T., Foster, E. Johan, Weder, Christoph, Capadona, Jeffrey R.

“…[Display omitted] The cellular and molecular mechanisms by which neuroinflammatory pathways respond to and propagate the reactive tissue response to…”
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Intravenous delivery of camptothecin-loaded PLGA nanoparticles for the treatment of intracranial glioma by Householder, Kyle T., DiPerna, Danielle M., Chung, Eugene P., Wohlleb, Gregory M., Dhruv, Harshil D., Berens, Michael E., Sirianni, Rachael W.

“…[Display omitted] Effective treatment of glioblastoma multiforme remains a major clinical challenge, due in part to the difficulty of delivering…”
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pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma by Householder, Kyle T., DiPerna, Danielle M., Chung, Eugene P., Luning, Anne Rosa, Nguyen, Duong T., Stabenfeldt, Sarah E., Mehta, Shwetal, Sirianni, Rachael W.

“…[Display omitted] •Ionized quisinostat is loaded more efficiently onto PLA-PEG nanoparticles.•Quisinostat potency is maintained through nanoparticle…”
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Abstract 1314: Evaluating payload delivery to the CNS from surface-modified nanoparticles by Householder, Kyle T., DiPerna, Danielle, Ghaffari, Layla, Sirianni, Rachael

“…The blood-brain barrier (BBB) remains a major obstacle to treatment of intracranial tumors. Most drugs are poorly bioavailable in the brain, and peripheral…”
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Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo by Medina, David X., Householder, Kyle T., Ceton, Ricki, Kovalik, Tina, Heffernan, John M., Shankar, Rohini V., Bowser, Robert P., Wechsler-Reya, Robert J., Sirianni, Rachael W.

“…Understanding of the mechanisms by which systemically administered nanoparticles achieve delivery across biological barriers remains incomplete, due in part to…”
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A comparison of neuroinflammation to implanted microelectrodes in rat and mouse models by Potter-Baker, Kelsey A, Ravikumar, Madhumitha, Burke, Alan A, Meador, William D, Householder, Kyle T, Buck, Amy C, Sunil, Smrithi, Stewart, Wade G, Anna, Jake P, Tomaszewski, William H, Capadona, Jeffrey R

“…Abstract Rat models have emerged as a common tool to study neuroinflammation to intracortical microelectrodes. While a number of studies have attempted to…”
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EXTH-61. NANOPARTICLE DELIVERY TO THE SPINAL CORD VIA DIRECT ADMINISTRATION TO CEREBROSPINAL FLUID by Householder, Kyle T., Chung, Eugene P., Enns, Justine, Sirianni, Rachael

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Abstract B21: Use of polymeric nanoparticles for the delivery of YM155 to glioma cells in vitro and in vivo by Householder, Kyle T., DiPerna, Danielle M., Yamaguchi, Jonathan T., Sanai, Nader, Mehta, Shwetal, Sirianni, Rachael W.

“…YM155 (Sepantronium Bromide) is a potent survivin inhibitor that is the subject of clinical trials for multiple types of cancer including melanoma, lypmphoma,…”
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Abstract 4579: Pathogen-derived targets for the delivery of chemotherapeutics to the brain by McCall, Rebecca L., Householder, Kyle T., Chung, Eugene P., Sirianni, Rachael W.

“…Introduction The blood-brain barrier (BBB) is a key obstacle to achieving better treatment of glioblastoma multiforme (GBM). Tight junctions in the BBB prevent…”
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Abstract 1329: Intravenous delivery of Erlotinib-loaded PLA-PEG nanoparticles for treatment of GB by Hartman, Lauren K., Dhruv, Harshil D., Householder, Kyle T., Roth, Jeffrey E., Schorzman, Allison N., Zamboni, William, Sirianni, Rachel, Berens, Michael E.

“…Amplification, overexpression, and mutation of the epidermal growth factor receptor (EGFR) gene represent common genetic signature abnormalities (>50%) in…”
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