Search Results - "Hounsou, Candide"

G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study by Hounsou, Candide, Guittat, Lionel, Monchaud, David, Jourdan, Muriel, Saettel, Nicolas, Mergny, Jean-Louis, Teulade-Fichou, Marie-Paule

“…The synthesis of a novel group of quinacridine‐based ligands (MMQs) is described along with an evaluation of their G‐quadruplex binding properties. A set of…”
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Telomerase Inhibitors Based on Quadruplex Ligands Selected by a Fluorescence Assay by Mergny, Jean-Louis, Lacroix, Laurent, Teulade-Fichou, Marie-Paule, Hounsou, Candide, Guittat, Lionel, Hoarau, Magali, Arimondo, Paola B., Vigneron, Jean-Pierre, Lehn, Jean-Marie, Riou, Jean-François, Garestier, Therese, Hélène, Claude

“…The reactivation of telomerase activity in most cancer cells supports the concept that telomerase is a relevant target in oncology, and telomerase inhibitors…”
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Palladium versus copper-catalyzed N-arylation towards an efficient access to polysubstituted dibenzophenanthrolines and carbazoles by Jacquelin, Clémence, Saettel, Nicolas, Hounsou, Candide, Teulade-Fichou, Marie-Paule

“…Compounds 1 are key precursors to polysubstituted dibenzophenanthrolines. The double amination of meta-diiodo and dibromobenzenes by anthranilic acid…”
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Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite® assays by Belhocine, Abderazak, Veglianese, Pietro, Hounsou, Candide, Dupuis, Elodie, Acher, Francine, Durroux, Thierry, Goudet, Cyril, Pin, Jean-Philippe

“…Group-III metabotropic glutamate (mGlu) receptors are important synaptic regulators and are potential druggable targets for Parkinson disease, autism and pain…”
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From the Promiscuous Asenapine to Potent Fluorescent Ligands Acting at a Series of Aminergic G‑Protein-Coupled Receptors by Hounsou, Candide, Baehr, Corinne, Gasparik, Vincent, Alili, Doria, Belhocine, Abderazak, Rodriguez, Thiéric, Dupuis, Elodie, Roux, Thomas, Mann, André, Heissler, Denis, Pin, Jean-Philippe, Durroux, Thierry, Bonnet, Dominique, Hibert, Marcel

“…Monoamine neurotransmitters such as serotonin, dopamine, histamine, and noradrenaline have important and varied physiological functions and similar chemical…”
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A Novel Approach to Indoloditerpenes by Nazarov Photocyclization: Synthesis and Biological Investigations of Terpendole E Analogues by Churruca, Fátima, Fousteris, Manolis, Ishikawa, Yuichi, von Wantoch Rekowski, Margarete, Hounsou, Candide, Surrey, Thomas, Giannis, Athanassios

“…The application of the Nazarov photocyclization as a mild and efficient method for access to the basic core of novel indoloditerpenoid derivatives is reported…”
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Time-resolved FRET strategy to screen GPCR ligand library by Oueslati, Nadia, Hounsou, Candide, Belhocine, Abderazak, Rodriguez, Thieric, Dupuis, Elodie, Zwier, Jurriaan M, Trinquet, Eric, Pin, Jean-Philippe, Durroux, Thierry

“…Screening chemical libraries to find specific drugs for G protein-coupled receptors is still of major interest. Indeed, because of their major roles in all…”
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Time-Resolved FRET Binding Assay to Investigate Hetero-Oligomer Binding Properties: Proof of Concept with Dopamine D1/D3 Heterodimer by Hounsou, Candide, Margathe, Jean-François, Oueslati, Nadia, Belhocine, Abderazak, Dupuis, Elodie, Thomas, Cécile, Mann, André, Ilien, Brigitte, Rognan, Didier, Trinquet, Eric, Hibert, Marcel, Pin, Jean-Philippe, Bonnet, Dominique, Durroux, Thierry

“…G protein-coupled receptors (GPCRs) have been described to form hetero-oligomers. The importance of these complexes in physiology and pathology is considered…”
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Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis by Flipo, Marion, Willand, Nicolas, Lecat-Guillet, Nathalie, Hounsou, Candide, Desroses, Matthieu, Leroux, Florence, Lens, Zoé, Villeret, Vincent, Wohlkönig, Alexandre, Wintjens, René, Christophe, Thierry, Kyoung Jeon, Hee, Locht, Camille, Brodin, Priscille, Baulard, Alain R, Déprez, Benoit

“…In this paper, we describe the screening of a 14640-compound library using a novel whole mycobacteria phenotypic assay to discover inhibitors of EthR, a…”
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PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil by Beghyn, Terence, Hounsou, Candide, Deprez, Benoit P.

“…The synthesis of potent PDE5 inhibitors is reported. Some heteroarylated compounds (e.g., 14a) display an improved aqueous solubility, when compared to…”
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Time-Resolved FRET Binding Assay to Investigate Hetero-Oligomer Binding Properties: Proof of Concept with Dopamine D 1 /D 3 Heterodimer by Hounsou, Candide, Margathe, Jean-François, Oueslati, Nadia, Belhocine, Abderazak, Dupuis, Elodie, Thomas, Cécile, Mann, André, Ilien, Brigitte, Rognan, Didier, Trinquet, Eric, Hibert, Marcel, Pin, Jean-Philippe, Bonnet, Dominique, Durroux, Thierry

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G‐quartets assembly within a G‐rich DNA flap. A possible event at the center of the HIV‐1 genome by Lyonnais, Sébastien, Hounsou, Candide, Teulade‐Fichou, Marie‐Paule, Jeusset, Josette, Cam, Eric Le, Mirambeau, Gilles

“…Stretches of guanines can associate in vitro through Hoogsteen hydrogen bonding to form four‐stranded structures. In the HIV‐1 central DNA flap, generated by…”
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G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study by Hounsou, Candide, Guittat, Lionel, Monchaud, David, Jourdan, Muriel, Saettel, Nicolas, Mergny, Jean-Louis, Teulade-Fichou, Marie-Paule

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