Search Results - "Houlihan, William J."

γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion by Barros, Marilia, Houlihan, William J, Paresi, Chelsea J, Brendel, Matthew, Rynearson, Kevin D, Lee, Chang-Wook, Prikhodko, Olga, Cregger, Cristina, Chang, Geoffrey, Wagner, Steven L, Gilchrist, M Lane, Li, Yue-Ming

“…γ-Secretase is a multisubunit complex that catalyzes intramembranous cleavage of transmembrane proteins. The lipid environment forms membrane microdomains that…”
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Antitumor Activity of 5-Aryl-2,3-dihydroimidazo[2,1-a]isoquinolines by Houlihan, William J, Munder, Paul G, Handley, Dean A, Cheon, Seung H, Parrino, Vincent A

“…A series of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinolines previously reported to be platelet activating factor (PAF) receptor antagonists were evaluated for…”
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Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists by Houlihan, William J, Cheon, Seung H, Parrino, Vincent A, Handley, Dean A, Larson, Douglas A

“…In an effort to determine the effect of modification of the imidazo[2,1-a]isoquinoline portion of the PAF-receptor antagonist SDZ 64-412 (1), several new…”
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Three-Dimensional Quantitative Structure−Activity Relationships of Mazindol Analogues at the Dopamine Transporter by Kulkarni, Santosh S, Newman, Amy Hauck, Houlihan, William J

“…A three-dimensional quantitative structure−activity relationship (3D-QSAR) study was performed on a series of mazindol analogues using the comparative…”
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Mazindol Analogues as Potential Inhibitors of the Cocaine Binding Site at the Dopamine Transporter by Houlihan, William J, Kelly, Lawrence, Pankuch, Jessica, Koletar, Judith, Brand, Leonard, Janowsky, Aaron, Kopajtic, Theresa A

“…A series of mazindol (2) and homomazindol (3) analogues with a variety of electron-donating and electron-withdrawing groups in the pendant aryl group and the…”
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Assessment of mazindane, a pro-drug form of mazindol, in assays used to define cocaine treatment agents by Houlihan, William J., Kelly, Lawrence

“…The current studies compared mazindane (5-(4-chlorophenyl)-2,3-dihydro-5H-imidazo [2,1a] isoindole) hydrogen sulfate, a water soluble pro-drug of mazindol…”
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Benzo- and Cyclohexanomazindol Analogues as Potential Inhibitors of the Cocaine Binding Site at the Dopamine Transporter by Houlihan, William J, Ahmad, Umer F, Koletar, Judith, Kelly, Lawrence, Brand, Leonard, Kopajtic, Theresa A

“…A series of mazindol (1), homomazindol (2), and bishomomazindol (3) derivatives with a benzo or cyclohexano ring fused at various sites were prepared as part…”
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Novel cycloaddition products formed by the modified Madelung indole synthesis by Houlihan, William J, Uike, Yasuyuki, Parrino, Vincent A

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Halogenated Mazindol Analogs as Potential Inhibitors of the Cocaine Binding Site at the Dopamine Transporter by Houlihan, William J, Boja, John W, Parrino, Vincent A, Kopajtic, Theresa A, Kuhar, Michael J

“…A series of halogenated (F, Cl, Br, I), pyrimido and diazepino homologs of mazindol were prepared and evaluated for their ability to displace [3H]WIN 35,428…”
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Dimeric Products from the Base-Catalyzed Condensation of Benzaldehyde with 2,3-Dihydro-1H-inden-1-one or 2-(Phenylmethylene)-2,3-dihydro-1H- inden-1-one by Houlihan, William J, Shapiro, Michael J, Chin, Jefferson A

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Modification of Lipid Microenvironments on Solid Support Structures for Use in Transmembrane Protein Assays by Houlihan, William J

“…Gamma-Secretase (γ-secretase) is a transmembrane protease of increasing interest, which has been shown to have significant connections to both cancer and…”
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High Affinity Recognition of Serotonin Transporter Antagonists Defined by Species-scanning Mutagenesis by Barker, Eric L., Perlman, Melody A., Adkins, Erika M., Houlihan, William J., Pristupa, Zdenek B., Niznik, Hyman B., Blakely, Randy D.

“…Human and Drosophila melanogasterserotonin (5-HT) transporters (SERTs) exhibit similar 5-HT transport kinetics and can be distinguished pharmacologically by…”
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Synthesis and biological evaluation of substituted 2,2'-oxybis(propionic acid) derivatives and related compounds by Bennett, Gregory B, Houlihan, William J, Mason, Robert B, Engstrom, Robert G

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Antitumor Activity of the R- and S-Enantiomers of RS-2-[[Hydroxy[[2-[(octadecyloxy)methyl]tetrahydrofuran-2-yl]methoxy]phosphinyl]oxy]-N,N,N-trimethylethylaminium Hydroxide Inner Salt by Houlihan, William J, Prasad, Kapa, Underwood, Russell, Repič, Oljan, Munder, Paul G

“…The R- and S-enantiomers of 2-[[hydroxy[[2-[(octadecyloxy)methyl]tetrahydrofuran-2-yl]methoxy]phosphinyl]oxy]-N,N,N-trimethylethylaminium hydroxide salt (SRI…”
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Lithiation of N-(2-alkylphenyl)alkanamides and related compounds. A modified Madelung indole synthesis by Houlihan, William J, Parrino, Vincent A, Uike, Yasuyuki

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Directed lithiation of 2-phenyl- and 2-(o-methylphenyl)imidazoline by Houlihan, William J, Parrino, Vincent A

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High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol by Barker, E L, Perlman, M A, Adkins, E M, Houlihan, W J, Pristupa, Z B, Niznik, H B, Blakely, R D

“…Human and Drosophila melanogaster serotonin (5-HT) transporters (SERTs) exhibit similar 5-HT transport kinetics and can be distinguished pharmacologically by…”
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The Addition of Methyl Grignard to 4-t-Butylcyclohexanone by Houlihan, William J

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Hofmann elimination of heterocycles containing bridgehead hydrazines. I. 2,6-Benzodiazonine and dibenzo[c,h][1,6]diazecine derivatives by Aeberli, Paul, Houlihan, William J

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Sleep-inducing N-alkyl-5-[m-(trifluoromethyl)phenyl]-5-hydroxy-2-pyrrolidinones and N-alkyl-3-(trifluoromethyl)cinnamamides by Houlihan, William J, Gogerty, John H, Ryan, Eileen A, Schmitt, Gemma

“…A series of N-alkyl-3-[m-(trifluoromethyl)phenyl]-5-hydroxy-2-pyrrolidinones and N-alkyl-3-(trifluoromethyl)-cinnamamides were prepared and screened in a…”
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