Search Results - "Houlbrook, Susan"

8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs by ROBBINS, Susan K, HOULBROOK, Susan, PRIDDLE, John D, HARRIS, Adrian L

“…8-Cl-cAMP has been undergoing clinical trials as a potential chemotherapy agent, but there is much discussion in the literature as to whether the active agent…”
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Evaluation of toremifene for reversal of multidrug resistance in renal cell cancer patients treated with vinblastine by BRAYBROOKE, J. P, VALLIS, K. A, HOULBROOK, S, ROCKETT, H, ELLMEN, J, ANTTILA, M, GANESAN, T. S, HARRIS, A. L, TALBOT, D. C

“…Expression of P-glycoprotein (Pgp), which confers the multidrug resistance (MDR) phenotype, is thought to contribute to the insensitivity of renal cell cancer…”
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Synthesis and Biological Activity of Thiazolylindolequinones, Analogs of the Natural Product BE 10988 by Moody, Christopher J, Swann, Elizabeth, Houlbrook, Susan, Stephens, Miriam A, Stratford, Ian J

“…A number of analogues of the naturally occurring thiazolylindolequinone BE 10988, a reported potent inhibitor of topoisomerase II, have been prepared and…”
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Synthesis and cytotoxic activity of thiazolyl indolequinones by Moody, C J, Roffey, J R, Swann, E, Lockyer, S, Houlbrook, S, Strafford, I J

“…A number of thiazolyl indolequinones have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate…”
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The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233) by Patterson, A V, Robertson, N, Houlbrook, S, Stephens, M A, Adams, G E, Harris, A L, Stratford, I J, Carmichael, J

“…To determine the dependency of the aerobic and hypoxic toxicity of tirapazamine on the intracellular activity of DT-diaphorase. A panel of 18 human cell lines…”
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