Search Results - "Houin, Georges"

Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo by Cornaire, Gilles, Woodley, John, Hermann, Philippe, Cloarec, Alix, Arellano, Cécile, Houin, Georges

“…The efflux transporter, P-glycoprotein (P-gp), located in the apical membranes of intestinal absorptive cells, can reduce the bioavailability of a wide range…”
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Population Pharmacokinetics of Ceftazidime in Intensive Care Unit Patients: Influence of Glomerular Filtration Rate, Mechanical Ventilation, and Reason for Admission by GEORGES, Bernard, CONIL, Jean-Marie, SAIVIN, Sylvie, SEGUIN, Thierry, RUIZ, Stéphanie, MINVILLE, Vincent, COUGOT, Pierre, DECUN, Jean-Franqois, GONZALEZ, Hélène, HOUIN, Georges, FOURCADE, Olivier

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Gastrointestinal absorption of drugs: methods and studies by Barthe, Laurence, Woodley, John, Houin, Georges

“…— Physico‐chemical descriptors of drug molecules are often not adequate in predicting their oral bioavailability. In vitro methods can be useful in evaluating…”
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Tobramycin disposition in ICU patients receiving a once daily regimen: population approach and dosage simulations by Conil, Jean‐Marie, Georges, Bernard, Ruiz, Stéphanie, Rival, Thomas, Seguin, Thierry, Cougot, Pierre, Fourcade, Olivier, Pharmd, Georges Houin, Saivin, Sylvie

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT? • It is well known that tobramycin given as an once daily dose according to the usual recommendations needs…”
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The influence of weightlessness on pharmacokinetics by Gandia, Peggy, Saivin, Sylvie, Houin, Georges

“…The primary hostile factor during a spaceflight is the lack of gravity, which can induce space motion sickness and act on bones, muscles and the cardiovascular…”
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The roles of P-glycoprotein and intracellular metabolism in the intestinal absorption of methadone: in vitro studies using the rat everted intestinal sac by Bouër, Ronan, Barthe, Laurence, Philibert, Claude, Tournaire, Cécile, Woodley, John, Houin, Georges

“…— Methadone is used as a treatment for opiate detoxification in methadone maintenance programs. Intra‐ and inter‐patient variations in methadone…”
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A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection by Sadiq, Muhammad W., Nielsen, Elisabet I., Khachman, Dalia, Conil, Jean-Marie, Georges, Bernard, Houin, Georges, Laffont, Celine M., Karlsson, Mats O., Friberg, Lena E.

“…The purpose of this study was to develop a whole-body physiologically based pharmacokinetic (WB-PBPK) model for ciprofloxacin for ICU patients, based on only…”
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Determination of Plasma Unbound Fraction of Voriconazole in Patients Treated With a Prophylactic or a Curative Treatment by FLORENT, Aurélie, GANDIA, Peggy, SERAISSO, Patrick, CHATELUT, Etienne, HOUIN, Georges

“…Voriconazole (VOR) is a triazole antifungal used in the curative treatment of invasive fungal infections and the prophylactic treatment of opportunistic fungal…”
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Ceftazidime dosage regimen in intensive care unit patients: from a population pharmacokinetic approach to clinical practice via Monte Carlo simulations by Georges, Bernard, Conil, Jean‐Marie, Ruiz, Stéphanie, Seguin, Thierry, Cougot, Pierre, Fourcade, Olivier, Houin, Georges, Saivin, Sylvie

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT The large variability in drug pharmacokinetic disposition has already been described in ICU patients leading to…”
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Medical and pharmacological approach to adjust the salbutamol anti-doping policy in athletes by Pillard, Fabien, Lavit, Michel, Cances, Valérie Lauwers, Rami, Jacques, Houin, Georges, Didier, Alain, Rivière, Daniel

“…Salbutamol abuse detection by athletes is based on a urinary upper threshold defined by the World Anti-Doping Agency (WADA). However, this threshold was…”
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Optimizing ciprofloxacin dosing in intensive care unit patients through the use of population pharmacokinetic-pharmacodynamic analysis and Monte Carlo simulations by Khachman, Dalia, Conil, Jean-Marie, Georges, Bernard, Saivin, Sylvie, Houin, Georges, Toutain, Pierre-Louis, Laffont, Celine M.

“…Objectives To explore different ciprofloxacin dosage regimens for the treatment of intensive care unit (ICU) patients with respect to clinical outcome and the…”
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Is Once-Daily Mesalazine Equivalent to the Currently Used Twice-Daily Regimen? A Study Performed in 30 Healthy Volunteers by Gandia, Peggy, Idier, Isabelle, Houin, Georges

“…A randomized, 2‐way, crossover study was conducted in 30 volunteers to compare the pharmacokinetic profile of a new once‐daily dosing regimen of mesalazine (1…”
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A population pharmacokinetic approach to ceftazidime use in burn patients: influence of glomerular filtration, gender and mechanical ventilation by Conil, Jean Marie, Georges, Bernard, Lavit, Michel, Laguerre, Jacky, Samii, Kamram, Houin, Georges, Saivin, Sylvie

“…What is already known about this subject • There is only one published study of the population pharmacokinetics of ceftazidime in burn patients. Only one…”
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Influence of renal function on trough serum concentrations of piperacillin in intensive care unit patients by CONIL, Jean-Marie, GEORGES, Bernard, MIMOZ, Olivier, DIEYE, Eric, RUIZ, Stéphanie, COUGOT, Pierre, SAMII, Kamran, HOUIN, Georges, SAIVIN, Sylvie

“…To explore the effects of renal function estimated by measured creatinine clearance (Cl(CR)) on trough serum concentration (C(min)) of piperacillin given to…”
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Tuberculosis: relevance of isoniazid dosage in prevention of liver side effects by Negri, Lucie, Le Grusse, Jean, Séraissol, Patrick, Lavit, Michel, Houin, Georges, Gandia, Peggy

“…Several recent studies have established a correlation between NAT2 polymorphism and hepatotoxicity induced by isoniazid. The objective of this work was to…”
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Ciprofloxacin use in critically ill patients: pharmacokinetic and pharmacodynamic approaches by Conil, Jean-Marie, Georges, Bernard, de Lussy, Anne, Khachman, Dalia, Seguin, Thierry, Ruiz, Stéphanie, Cougot, Pierre, Fourcade, Olivier, Houin, Georges, Saivin, Sylvie

“…Abstract The objective of this study was to evaluate the properties of ciprofloxacin in intensive care patients using a population approach. Seventy patients…”
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In vitro Intestinal Degradation and Absorption of Chondroitin Sulfate, a Glycosaminoglycan Drug by Barthe, Laurence, Woodley, John, Lavit, Michel, Przybylski, Chistophe, Philibert, Claude, Houin, Georges

“…Summary Chondroitin sulfate (CAS 24967-93-9, CS) is a natural polymer of a disaccharide consisting of glucuronic acid and N-acetyl glucosamine which is…”
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The metabolism of midazolam and comparison with other CYP enzyme substrates during intestinal absorption: in vitro studies with rat everted gut sacs by Arellano, Cécile, Philibert, Claude, Vachoux, Christelle, Woodley, John, Houin, Georges

“…The purpose of this study was to quantify the intestinal metabolism of midazolam, a CYP P450 substrate, usually used as a probe for the activity of the isoform…”
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Assessment of renal function in clinical practice at the bedside of burn patients by Conil, J. M., Georges, B., Fourcade, O., Seguin, T., Lavit, M., Samii, K., Houin, G., Tack, I., Saivin, S.

“…What is already known about this subject • In burn patients it has been shown ([2]), that there is a correlation between the creatinine clearance (CLCR) and…”
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Influence of Simulated Weightlessness on the Intramuscular and Oral Pharmacokinetics of Promethazine in 12 Human Volunteers by Gandia, Peggy, Saivin, Sylvie, Le-Traon, Anne Pavy, Guell, Antonio, Houin, Georges

“…The National Aeronautics and Space Administration (NASA) recommends using promethazine to prevent and treat space motion sickness, but pharmacologic responses…”
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