Search Results - "Houchen, C"
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DCLK1 as part of EMT feedback-loop promotes colorectal cancer cell proliferation, invasion, and 5-Fu resistance
Published in Annals of oncology (01-11-2018)Get full text
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Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe
Published in Oncogene (31-07-2008)“…RNA-binding proteins play a key role in post-transcriptional regulation of mRNA stability and translation. We have identified that RBM3, a translation…”
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Utility of a bacterial infection model to study epithelial–mesenchymal transition, mesenchymal–epithelial transition or tumorigenesis
Published in Oncogene (15-05-2014)“…DCLK1 and Lgr5 have recently been identified as markers of quiescent and cycling stem cells in the small intestinal crypts, respectively…”
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Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence
Published in Cell death & disease (22-05-2014)“…Hyperactivation of the Wingless-type (Wnt)/ β -catenin pathway promotes tumor initiation, tumor growth and metastasis in various tissues. Although there is…”
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Cancer stem cells: a novel paradigm for cancer prevention and treatment
Published in Mini reviews in medicinal chemistry (01-05-2010)“…Cancer is the second leading cause for mortality in US only after heart disease and lacks a good or effective therapeutic paradigm. Despite the emergence of…”
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Epithelial apoptosis in mechanistically distinct methods of injury in the murine small intestine
Published in Histology and histopathology (01-06-2007)“…Gut epithelial apoptosis is involved in the pathophysiology of multiple diseases. This study characterized intestinal apoptosis in three mechanistically…”
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Coupled mRNA Stabilization and Translational Silencing of Cyclooxygenase-2 by a Novel RNA Binding Protein, CUGBP2
Published in Molecular cell (2003)“…Cyclooxygenase-2 (COX-2) expression is translationally silenced in epithelial cells undergoing radiation-induced apoptosis. CUGBP2, a predominantly nuclear…”
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140PDCLK1 as part of EMT feedback-loop promotes colorectal cancer cell proliferation, invasion, and 5-Fu resistance
Published in Annals of oncology (01-11-2018)Get full text
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Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury
Published in American journal of physiology: Gastrointestinal and liver physiology (01-11-2000)“…Prostaglandins may play an important role in regulating normal renewal of gastrointestinal epithelium, epithelial injury repair, and initiation or progression…”
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Clinical implications of prostaglandin inhibition in the small bowel
Published in Gastroenterology clinics of North America (01-12-2001)“…NSAID-induced intestinal toxicity is more common than previously recognized and may have clinically significant sequelae, especially in elderly arthritic…”
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Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases
Published in Journal of inflammation research (01-01-2020)“…Non-steroidal anti-inflammatory drugs, cyclooxygenase (COX)-2 selective inhibitors, have been explored for prevention and treatment of several inflammatory…”
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Cyclooxygenase expression in intestinal epithelial cells
Published in Current opinion in gastroenterology (01-03-1999)Get full text
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Dichotomous metabolism of Enterococcus faecalis induced by haematin starvation modulates colonic gene expression
Published in Journal of medical microbiology (01-10-2008)“…1 Muchmore Laboratories for Infectious Disease Research, Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA 2 Department of Medicine,…”
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Radiation injury induces expression of a novel COX-2 mRNA binding protein, CUGBP2 in intestinal epithelial cells
Published in Gastroenterology (New York, N.Y. 1943) (01-04-2001)Get full text
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Expression, function, and localization of the REG cell surface receptor
Published in Gastroenterology (New York, N.Y. 1943) (01-04-2001)Get full text
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EP2 receptor null mice have an impaired intestinal response to radiation injury
Published in Gastroenterology (New York, N.Y. 1943) (01-04-2001)Get full text
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Reg IV Activates the Epidermal Growth Factor Receptor/Akt/AP-1 Signaling Pathway in Colon Adenocarcinomas
Published in Gastroenterology (New York, N.Y. 1943) (01-01-2006)“…Background & Aims: Reg IV, a secreted protein and member of the Reg multigene family, is up-regulated in malignancies of the human gastrointestinal tract,…”
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PEGylated murine Granulocyte–macrophage colony-stimulating factor: Production, purification, and characterization
Published in Protein expression and purification (01-12-2005)“…Granulocyte–macrophage colony-stimulating factor (GM-CSF) regulates proliferation, differentiation, and function of hematopoietic progenitor cells. Aside from…”
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