Search Results - "Hou, Zhanjun"

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates by O’Connor, Carrie, Wallace-Povirk, Adrianne, Ning, Changwen, Frühauf, Josephine, Tong, Nian, Gangjee, Aleem, Matherly, Larry H., Hou, Zhanjun

“…There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled…”
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Biology of the Major Facilitative Folate Transporters SLC19A1 and SLC46A1 by Hou, Zhanjun, Matherly, Larry H.

“…This chapter focuses on the biology of the major facilitative membrane folate transporters, the reduced folate carrier (RFC), and the proton-coupled folate…”
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The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer by Matherly, Larry H, Wilson, Mike R, Hou, Zhanjun

“…This review summarizes the biology of the major facilitative membrane transporters, the reduced folate carrier (RFC) (Solute Carrier 19A1) and the…”
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Human reduced folate carrier: translation of basic biology to cancer etiology and therapy by Matherly, Larry H, Hou, Zhanjun, Deng, Yijun

“…This review attempts to provide a comprehensive overview of the biology of the physiologically and pharmacologically important transport system termed the…”
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Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment by Wallace-Povirk, Adrianne, Rubinsak, Lisa, Malysa, Agnes, Dzinic, Sijana H., Ravindra, Manasa, Schneider, Mathew, Glassbrook, James, O’Connor, Carrie, Hou, Zhanjun, Kim, Seongho, Back, Jessica, Polin, Lisa, Morris, Robert T., Gangjee, Aleem, Gibson, Heather, Matherly, Larry H.

“…Novel therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. In addition, therapies that target unique…”
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Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3- d ]pyrimidine Antifolates by Hou, Zhanjun, Gattoc, Leda, O'Connor, Carrie, Yang, Si, Wallace-Povirk, Adrianne, George, Christina, Orr, Steve, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Morris, Robert T, Gangjee, Aleem, Matherly, Larry H

“…Folate uptake in epithelial ovarian cancer (EOC) involves the reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT), both facilitative…”
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Synthesis and Discovery of High Affinity Folate Receptor-Specific Glycinamide Ribonucleotide Formyltransferase Inhibitors with Antitumor Activity by Deng, Yijun, Wang, Yiqiang, Cherian, Christina, Hou, Zhanjun, Buck, Steven A, Matherly, Larry H, Gangjee, Aleem

“…6-Substituted classical pyrrolo[2,3-d]pyrimidine antifolates with a three- to six-carbon bridge between the heterocycle and the benzoyl-l-glutamate (compounds…”
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Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry by Deng, Yijun, Zhou, Xilin, Kugel Desmoulin, Sita, Wu, Jianmei, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H, Gangjee, Aleem

“…A series of seven 2-amino-4-oxo-6-substituted thieno[2,3-d]pyrimidines with bridge length variations (from 2 to 8 carbon atoms) were synthesized as selective…”
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Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter by Kugel Desmoulin, Sita, Wang, Lei, Hales, Eric, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Stout, Mark, Hou, Zhanjun, Cherian, Christina, Gangjee, Aleem, Matherly, Larry H

“…The proton-coupled folate transporter (PCFT) is a proton-folate symporter with an acidic pH optimum. By real-time reverse transcription-polymerase chain…”
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Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry by Wang, Lei, Cherian, Christina, Kugel Desmoulin, Sita, Polin, Lisa, Deng, Yijun, Wu, Jianmei, Hou, Zhanjun, White, Kathryn, Kushner, Juiwanna, Matherly, Larry H, Gangjee, Aleem

“…2-Amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidines with a thienoyl side chain and four to six carbon bridge lengths (compounds 1−3) were synthesized as…”
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Pattern Analysis of Organellar Maps for Interpretation of Proteomic Data by Burton, Jordan B, Carruthers, Nicholas J, Hou, Zhanjun, Matherly, Larry H, Stemmer, Paul M

“…Localization of organelle proteins by isotope tagging (LOPIT) maps are a coordinate-directed representation of proteome data that can aid in biological…”
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Discovery of 5‑Substituted Pyrrolo[2,3‑d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity by Mitchell-Ryan, Shermaine, Wang, Yiqiang, Raghavan, Sudhir, Ravindra, Manasa Punaha, Hales, Eric, Orr, Steven, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H, Gangjee, Aleem

“…We synthesized 5-substituted pyrrolo[2,3-d]pyrimidine antifolates (compounds 5–10) with one-to-six bridge carbons and a benozyl ring in the side chain as…”
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Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6 by Wilson, Mike R, Kugel, Sita, Huang, Jenny, Wilson, Lucas J, Wloszczynski, Patrick A, Ye, Jun, Matherly, Larry H, Hou, Zhanjun

“…The human proton-coupled folate transporter (hPCFT) is expressed in solid tumours and is active at pHs characterizing the tumour microenvironment. Recent…”
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Identification and Functional Impact of Homo-oligomers of the Human Proton-coupled Folate Transporter by Hou, Zhanjun, Kugel Desmoulin, Sita, Etnyre, Erika, Olive, Mary, Hsiung, Benjamin, Cherian, Christina, Wloszczynski, Patrick A., Moin, Kamiar, Matherly, Larry H.

“…The proton-coupled folate transporter (PCFT; SLC46A1) is a proton-folate symporter that is abundantly expressed in solid tumors and normal tissues, such as…”
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Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter by Cherian, Christina, Kugel Desmoulin, Sita, Wang, Lei, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Stout, Mark, Hou, Zhanjun, Gangjee, Aleem, Matherly, Larry H.

“…Purpose We examined whether the novel 6-substituted pyrrolo[2,3- d ]pyrimidine thienoyl antifolate, compound 2 , might be an effective treatment for malignant…”
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Oligomeric Structure of the Human Reduced Folate Carrier by Hou, Zhanjun, Matherly, Larry H.

“…The ubiquitously expressed reduced folate carrier (RFC) is the major transport system for folate cofactors in mammalian cells and tissues. Previous…”
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The Metal Specificity and Selectivity of ZntA from Escherichia coli Using the Acylphosphate Intermediate by Hou, Zhanjun, Mitra, Bharati

“…ZntA from Escherichia coli is a P-type ATPase that confers resistance to Pb(II), Zn(II), and Cd(II) in vivo. We had previously shown that purified ZntA shows…”
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Identification of the Minimal Functional Unit of the Homo-oligomeric Human Reduced Folate Carrier by Hou, Zhanjun, Cherian, Christina, Drews, Joseph, Wu, Jianmei, Matherly, Larry H

“…The reduced folate carrier (RFC) is the major transport system for folates in mammals. We previously demonstrated the existence of human RFC (hRFC)…”
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Transmembrane Domains 4, 5, 7, 8, and 10 of the Human Reduced Folate Carrier Are Important Structural or Functional Components of the Transmembrane Channel for Folate Substrates by Hou, Zhanjun, Ye, Jun, Haska, Christina L., Matherly, Larry H.

“…The human reduced folate carrier (hRFC) facilitates membrane transport of folates and antifolates. hRFC is characterized by 12 transmembrane domains (TMDs). To…”
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Role of lysine 411 in substrate carboxyl group binding to the human reduced folate carrier, as determined by site-directed mutagenesis and affinity inhibition by Deng, Yijun, Hou, Zhanjun, Wang, Lei, Cherian, Christina, Wu, Jianmei, Gangjee, Aleem, Matherly, Larry H

“…Reduced folate carrier (RFC) is the major membrane transporter for folates and antifolates in mammalian tissues. Recent studies used radioaffinity labeling…”
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