Search Results - "Hou, Yixuan"

Emerging Highly Virulent Porcine Epidemic Diarrhea Virus: Molecular Mechanisms of Attenuation and Rational Design of Live Attenuated Vaccines by Hou, Yixuan, Wang, Qiuhong

“…The highly virulent porcine epidemic diarrhea virus (PEDV) emerged in China in 2010. It infects pigs of all ages, and causes severe diarrhea and high mortality…”
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Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid by Iserman, Christiane, Roden, Christine A., Boerneke, Mark A., Sealfon, Rachel S.G., McLaughlin, Grace A., Jungreis, Irwin, Fritch, Ethan J., Hou, Yixuan J., Ekena, Joanne, Weidmann, Chase A., Theesfeld, Chandra L., Kellis, Manolis, Troyanskaya, Olga G., Baric, Ralph S., Sheahan, Timothy P., Weeks, Kevin M., Gladfelter, Amy S.

“…We report that the SARS-CoV-2 nucleocapsid protein (N-protein) undergoes liquid-liquid phase separation (LLPS) with viral RNA. N-protein condenses with…”
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A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures by Dinnon, Kenneth H., Leist, Sarah R., Schäfer, Alexandra, Edwards, Caitlin E., Martinez, David R., Montgomery, Stephanie A., West, Ande, Yount, Boyd L., Hou, Yixuan J., Adams, Lily E., Gully, Kendra L., Brown, Ariane J., Huang, Emily, Bryant, Matthew D., Choong, Ingrid C., Glenn, Jeffrey S., Gralinski, Lisa E., Sheahan, Timothy P., Baric, Ralph S.

“…Coronaviruses are prone to transmission to new host species, as recently demonstrated by the spread to humans of severe acute respiratory syndrome coronavirus…”
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A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice by Leist, Sarah R., Dinnon, Kenneth H., Schäfer, Alexandra, Tse, Longping V., Okuda, Kenichi, Hou, Yixuan J., West, Ande, Edwards, Caitlin E., Sanders, Wes, Fritch, Ethan J., Gully, Kendra L., Scobey, Trevor, Brown, Ariane J., Sheahan, Timothy P., Moorman, Nathaniel J., Boucher, Richard C., Gralinski, Lisa E., Montgomery, Stephanie A., Baric, Ralph S.

“…The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures…”
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A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability by Zhu, Pengpeng, He, Fang, Hou, Yixuan, Tu, Gang, Li, Qiao, Jin, Ting, Zeng, Huan, Qin, Yilu, Wan, Xueying, Qiao, Yina, Qiu, Yuxiang, Teng, Yong, Liu, Manran

“…The hostile hypoxic microenvironment takes primary responsibility for the rapid expansion of breast cancer tumors. However, the underlying mechanism is not…”
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SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo by Hou, Yixuan J, Chiba, Shiho, Halfmann, Peter, Ehre, Camille, Kuroda, Makoto, Dinnon, 3rd, Kenneth H, Leist, Sarah R, Schäfer, Alexandra, Nakajima, Noriko, Takahashi, Kenta, Lee, Rhianna E, Mascenik, Teresa M, Graham, Rachel, Edwards, Caitlin E, Tse, Longping V, Okuda, Kenichi, Markmann, Alena J, Bartelt, Luther, de Silva, Aravinda, Margolis, David M, Boucher, Richard C, Randell, Scott H, Suzuki, Tadaki, Gralinski, Lisa E, Kawaoka, Yoshihiro, Baric, Ralph S

“…The spike aspartic acid-614 to glycine (D614G) substitution is prevalent in global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but…”
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Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes by Voss, William N, Hou, Yixuan J, Johnson, Nicole V, Delidakis, George, Kim, Jin Eyun, Javanmardi, Kamyab, Horton, Andrew P, Bartzoka, Foteini, Paresi, Chelsea J, Tanno, Yuri, Chou, Chia-Wei, Abbasi, Shawn A, Pickens, Whitney, George, Katia, Boutz, Daniel R, Towers, Dalton M, McDaniel, Jonathan R, Billick, Daniel, Goike, Jule, Rowe, Lori, Batra, Dhwani, Pohl, Jan, Lee, Justin, Gangappa, Shivaprakash, Sambhara, Suryaprakash, Gadush, Michelle, Wang, Nianshuang, Person, Maria D, Iverson, Brent L, Gollihar, Jimmy D, Dye, John, Herbert, Andrew, Finkelstein, Ilya J, Baric, Ralph S, McLellan, Jason S, Georgiou, George, Lavinder, Jason J, Ippolito, Gregory C

“…The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following SARS-CoV-2 infection are…”
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The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients by Premkumar, Lakshmanane, Segovia-Chumbez, Bruno, Jadi, Ramesh, Martinez, David R, Raut, Rajendra, Markmann, Alena, Cornaby, Caleb, Bartelt, Luther, Weiss, Susan, Park, Yara, Edwards, Caitlin E, Weimer, Eric, Scherer, Erin M, Rouphael, Nadine, Edupuganti, Srilatha, Weiskopf, Daniela, Tse, Longping V, Hou, Yixuan J, Margolis, David, Sette, Alessandro, Collins, Matthew H, Schmitz, John, Baric, Ralph S, de Silva, Aravinda M

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in late 2019 is responsible for a pandemic of severe respiratory illness…”
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Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection by Edwards, Caitlin E., Yount, Boyd L., Graham, Rachel L., Leist, Sarah R., Hou, Yixuan J., Dinnon, Kenneth H., Sims, Amy C., Swanstrom, Jesica, Gully, Kendra, Scobey, Trevor D., Cooley, Michelle R., Currie, Caroline G., Randell, Scott H., Baric, Ralph S.

“…Zoonotic coronaviruses represent an ongoing threat, yet the myriads of circulating animal viruses complicate the identification of higher-risk isolates that…”
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A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2 by Hassan, Ahmed O., Kafai, Natasha M., Dmitriev, Igor P., Fox, Julie M., Smith, Brittany K., Harvey, Ian B., Chen, Rita E., Winkler, Emma S., Wessel, Alex W., Case, James Brett, Kashentseva, Elena, McCune, Broc T., Bailey, Adam L., Zhao, Haiyan, VanBlargan, Laura A., Dai, Ya-Nan, Ma, Meisheng, Adams, Lucas J., Shrihari, Swathi, Danis, Jonathan E., Gralinski, Lisa E., Hou, Yixuan J., Schäfer, Alexandra, Kim, Arthur S., Keeler, Shamus P., Weiskopf, Daniela, Baric, Ralph S., Holtzman, Michael J., Fremont, Daved H., Curiel, David T., Diamond, Michael S.

“…The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a…”
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Comparison of Subgenomic and Total RNA in SARS-CoV-2 Challenged Rhesus Macaques by Dagotto, Gabriel, Mercado, Noe B, Martinez, David R, Hou, Yixuan J, Nkolola, Joseph P, Carnahan, Robert H, Crowe, Jr, James E, Baric, Ralph S, Barouch, Dan H

“…Respiratory virus challenge studies involve administration of the challenge virus and sampling to assess for protection from the same anatomical locations. It…”
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A recombination-resistant genome for live attenuated and stable PEDV vaccines by engineering the transcriptional regulatory sequences by Niu, Xiaoyu, Liu, Mingde, Yang, Shaomin, Xu, Jiayu, Hou, Yixuan J, Liu, Dongxiao, Tang, Qiyi, Zhu, Hua, Wang, Qiuhong

“…Coronaviruses are important pathogens of humans and animals, and vaccine developments against them are imperative. Due to the ability to induce broad and…”
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A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties by Liu, Shuiqing, Sun, Yan, Hou, Yixuan, Yang, Liping, Wan, Xueying, Qin, Yilu, Liu, Yongcan, Wang, Rui, Zhu, Pengpeng, Teng, Yong, Liu, Manran

“…Abstract Background Cancer stem cells (CSCs) are considered as the major cause to tumor initiation, recurrence, metastasis, and drug resistance, driving poor…”
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Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome by Zhang, Kaiming, Zheludev, Ivan N., Hagey, Rachel J., Haslecker, Raphael, Hou, Yixuan J., Kretsch, Rachael, Pintilie, Grigore D., Rangan, Ramya, Kladwang, Wipapat, Li, Shanshan, Wu, Marie Teng-Pei, Pham, Edward A., Bernardin-Souibgui, Claire, Baric, Ralph S., Sheahan, Timothy P., D’Souza, Victoria, Glenn, Jeffrey S., Chiu, Wah, Das, Rhiju

“…Drug discovery campaigns against COVID-19 are beginning to target the SARS-CoV-2 RNA genome. The highly conserved frameshift stimulation element (FSE),…”
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De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2 by Linsky, Thomas W, Vergara, Renan, Codina, Nuria, Nelson, Jorgen W, Walker, Matthew J, Su, Wen, Barnes, Christopher O, Hsiang, Tien-Ying, Esser-Nobis, Katharina, Yu, Kevin, Reneer, Z Beau, Hou, Yixuan J, Priya, Tanu, Mitsumoto, Masaya, Pong, Avery, Lau, Uland Y, Mason, Marsha L, Chen, Jerry, Chen, Alex, Berrocal, Tania, Peng, Hong, Clairmont, Nicole S, Castellanos, Javier, Lin, Yu-Ru, Josephson-Day, Anna, Baric, Ralph S, Fuller, Deborah H, Walkey, Carl D, Ross, Ted M, Swanson, Ryan, Bjorkman, Pamela J, Gale, Jr, Michael, Blancas-Mejia, Luis M, Yen, Hui-Ling, Silva, Daniel-Adriano

“…We developed a de novo protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracellular host proteins to infect the…”
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Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis by Peng, Meixi, Yang, Dan, Hou, Yixuan, Liu, Shuiqing, Zhao, Maojia, Qin, Yilu, Chen, Rui, Teng, Yong, Liu, Manran

“…Citrate, a substance being related to de novo fatty acid synthesis and tricarboxylic acid (TCA) cycle, has a pivotal role in cell survival. However, the…”
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Evaluation of heavy metal distribution characteristics of agricultural soil–rice system in a high geological background area according to the influence index of comprehensive quality (IICQ) by Liu, Shuang, Zhao, Huafu, Wu, Kening, Zhang, Zhuo, Hou, Yixuan, Chen, Tingyong, Jin, Qiu

“…Heavy metal pollution is a global ecological safety issue, especially in crops, where it directly threatens regional ecological security and human health…”
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Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replication by Niu, Xiaoyu, Kong, Fanzhi, Hou, Yixuan J, Wang, Qiuhong

“…Abstract Background Coronavirus (CoV) nonstructural protein 14 (nsp14) has exoribonuclease (ExoN) activity, responsible for proofreading and contributing to…”
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Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays by Sholukh, Anton M, Fiore-Gartland, Andrew, Ford, Emily S, Miner, Maurine D, Hou, Yixuan J, Tse, Longping V, Kaiser, Hannah, Zhu, Haiying, Lu, Joyce, Madarampalli, Bhanupriya, Park, Arnold, Lempp, Florian A, St Germain, Russell, Bossard, Emily L, Kee, Jia Jin, Diem, Kurt, Stuart, Andrew B, Rupert, Peter B, Brock, Chance, Buerger, Matthew, Doll, Margaret K, Randhawa, April Kaur, Stamatatos, Leonidas, Strong, Roland K, McLaughlin, Colleen, Huang, Meei-Li, Jerome, Keith R, Baric, Ralph S, Montefiori, David, Corey, Lawrence

“…Determinants of protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection require the development of…”
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Molecular mechanisms of Thrombospondin-2 modulates tumor vasculogenic mimicry by PI3K/AKT/mTOR signaling pathway by Huang, Ju, Wang, Congcong, Hou, Yixuan, Tian, Yuanyuan, Li, Yanru, Zhang, Haiying, Zhang, Lihong, Li, Wei

“…Vasculogenic mimicry (VM) differs from the classical tumor angiogenesis model. VM does not depend on endothelial cells; instead, highly aggressive tumor cells…”
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