Search Results - "Hou, Shengping"

The cancer exosomes: Clinical implications, applications and challenges by Tang, Zhenye, Li, Dongpei, Hou, Shengping, Zhu, Xiao

“…The exosome is a small functional vesicle enriched in selected proteins, lipids and nucleic acids, displaying distinct molecular heterogeneity. Exosomes…”
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YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2 by Wang, Xiaotang, Fan, Wei, Li, Na, Ma, Yan, Yao, Mudi, Wang, Guoqing, He, Siyuan, Li, Wanqian, Tan, Jun, Lu, Qi, Hou, Shengping

“…Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the…”
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Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization by Wang, Guoqing, Li, Xingran, Li, Na, Wang, Xiaotang, He, Siyuan, Li, Wanqian, Fan, Wei, Li, Ruonan, Liu, Jiangyi, Hou, Shengping

“…Uveitis causes blindness and critical visual impairment in people of all ages, and retinal microglia participate in uveitis progression. Unfortunately,…”
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A metagenomic study of the gut microbiome in Behcet's disease by Ye, Zi, Zhang, Ni, Wu, Chunyan, Zhang, Xinyuan, Wang, Qingfeng, Huang, Xinyue, Du, Liping, Cao, Qingfeng, Tang, Jihong, Zhou, Chunjiang, Hou, Shengping, He, Yue, Xu, Qian, Xiong, Xiao, Kijlstra, Aize, Qin, Nan, Yang, Peizeng

“…Behcet's disease (BD) is a recalcitrant, multisystemic inflammatory disease that can lead to irreversible blindness. Microbial agents have been considered to…”
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Low Expression of YTH Domain-Containing 1 Promotes Microglial M1 Polarization by Reducing the Stability of Sirtuin 1 mRNA by Zhou, Hongxiu, Xu, Zongren, Liao, Xingyun, Tang, Shiyun, Li, Na, Hou, Shengping

“…The N6-methyladenosine (m6A) modification is the most abundant posttranscriptional mRNA modification in mammalian cells and is dynamically modulated by a…”
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Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation by Tan, Jun, Liu, Huan, Huang, Minhao, Li, Na, Tang, Shibing, Meng, Jiayu, Tang, Shiyun, Zhou, Hongxiu, Kijlstra, Aize, Yang, Peizeng, Hou, Shengping

“…Th17 cells, a lymphocyte subpopulation that is characterized by the expression of the transcription factor “retinoic acid receptor-related orphan receptor…”
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Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study by Hou, Shengping, Yang, Zhenglin, Du, Liping, Jiang, Zhengxuan, Shu, Qinmeng, Chen, Yuanyuan, Li, Fuzhen, Zhou, Qingyun, Ohno, Shigeaki, Chen, Rui, Kijlstra, Aize, Rosenbaum, James T., Yang, Peizeng

“…Objective To identify susceptibility loci for Behçet's disease (BD) and elucidate their functional role. Methods A genome‐wide association study (GWAS) and…”
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A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis by Fan, Wei, Zeng, Shuhao, Wang, Xiaotang, Wang, Guoqing, Liao, Dan, Li, Ruonan, He, Siyuan, Li, Wanqian, Huang, Jiaxing, Li, Xingran, Liu, Jiangyi, Li, Na, Hou, Shengping

“…Vascular endothelial growth factor (VEGF) is one of the most powerful proangiogenic factors and plays an important role in multiple diseases. Increased…”
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Inflammasome-targeting natural compounds in inflammatory bowel disease: Mechanisms and therapeutic potential by Xu, Qiuyun, Sun, Weichen, Zhang, Jie, Mei, Youmin, Bao, Jingyin, Hou, Shengping, Zhou, Xiaorong, Mao, Liming

“…Inflammatory bowel disease (IBD), mainly including Crohn’s disease and ulcerative colitis, seriously affects human health and causes substantial social and…”
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m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells by Zhou, Qian, Liu, Xianyang, Lu, Huiping, Li, Na, Meng, Jiayu, Huang, Jiaxing, Zhang, Zhi, Liu, Jiangyi, Fan, Wei, Li, Wanqian, Li, Xingran, Liu, Xiaoyan, Zuo, Hangjia, Yang, Peizeng, Hou, Shengping

“…Retinal neovascularization (RNV) disease is one of the leading causes of blindness, yet the molecular underpinnings of this condition are not well understood…”
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Aryl Hydrocarbon Receptor Regulates Apoptosis and Inflammation in a Murine Model of Experimental Autoimmune Uveitis by Huang, Yike, He, Junchi, Liang, Huaping, Hu, Ke, Jiang, Shaoqiu, Yang, Lu, Mei, Suyin, Zhu, Xiao, Yu, Jing, Kijlstra, Aize, Yang, Peizeng, Hou, Shengping

“…Uveitis is characterized as a common cause of blindness worldwide. Aryl hydrocarbon receptor (AhR), a ligand-activated nuclear receptor, has been implicated to…”
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Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3 by Hou, Shengping, Du, Liping, Lei, Bo, Pang, Chi Pui, Zhang, Meifen, Zhuang, Wenjuan, Zhang, Minglian, Huang, Lulin, Gong, Bo, Wang, Meilin, Zhang, Qi, Hu, Ke, Zhou, Qingyun, Qi, Jian, Wang, Chaokui, Tian, Yuan, Ye, Zi, Liang, Liang, Yu, Hongsong, Li, Hong, Zhou, Yan, Cao, Qingfeng, Liu, Yunjia, Bai, Lin, Liao, Dan, Kijlstra, Aize, Xu, Jianfeng, Yang, Zhenglin, Yang, Peizeng

“…Peizeng Yang, Zhenglin Yang and colleagues report results of a genome-wide association study of Vogt-Koyanagi-Harada syndrome. They confirm strong association…”
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Activated carbon prepared from waste tire pyrolysis carbon black via CO2/KOH activation used as supercapacitor electrode by Hou, ShengPing, Zhang, Da, Xie, ZhiPeng, Kang, Yao, Tang, ZhengGang, Dai, YongNian, Lei, Yong, Chen, Jian, Liang, Feng

“…As the quantity of waste tires increases, more pyrolysis carbon black (CBp), a type of low value-added carbon black, is being produced. However, the…”
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METTL3 inhibits inflammation of retinal pigment epithelium cells by regulating NR2F1 in an m6A-dependent manner by Meng, Jiayu, Liu, Xianyang, Tang, Shiyun, Liu, Yusen, Zhao, Chenyang, Zhou, Qian, Li, Na, Hou, Shengping

“…N 6 -metyladenosine (m 6 A) RNA methylation has been proven to be involved in diverse biological processes, but its potential roles in the development of…”
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Genetic Variation in the REL Gene Increases Risk of Behcet's Disease in a Chinese Han Population but That of PRKCQ Does Not by Chen, Feilan, Xu, Lei, Zhao, Tingting, Xiao, Xiang, Pan, Yongquan, Hou, Shengping

“…Genome-wide association studies (GWAS) and candidate gene studies have identified the REL and PRKCQ genes as risk loci for various autoimmune diseases. The…”
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Increased Notch pathway activation in Behçet's disease by Qi, Jian, Yang, Yan, Hou, Shengping, Qiao, Yanbin, Wang, Qian, Yu, Hongsong, Zhang, Qi, Cai, Tao, Kijlstra, Aize, Yang, Peizeng

“…Behçet's disease (BD) is a refractory inflammatory disorder with unknown causes. Since the Notch pathway is critically involved in the immune response, the…”
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Two-stage association study in Chinese Han identifies two independent associations in CCR1/CCR3 locus as candidate for Behçet’s disease susceptibility by Hou, Shengping, Xiao, Xiang, Li, Fuzhen, Jiang, Zhengxuan, Kijlstra, Aize, Yang, Peizeng

“…Previous GWAS studies from Turkey suggested a potential risk locus at CCR1 / CCR3 for Behçet’s disease. However, this locus did not reach the GWAS significance…”
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YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes by Huang, Jiaxing, Wang, Xiaotang, Li, Na, Fan, Wei, Li, Xingran, Zhou, Qian, Liu, Jiangyi, Li, Wanqian, Zhang, Zhi, Liu, Xiaoyan, Zeng, Shuhao, Yang, Hui, Tian, Meng, Yang, Peizeng, Hou, Shengping

“…Activated microglia in the retina are essential for the development of autoimmune uveitis. Yin‐Yang 1 (YY1) is an important transcription factor that…”
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TNFAIP3 gene polymorphisms confer risk for Behcet’s disease in a Chinese Han population by Li, Hong, Liu, Qing, Hou, Shengping, Du, Liping, Zhou, Qingyun, Zhou, Yan, Kijlstra, Aize, Li, Zheng, Yang, Peizeng

“…The tumor necrosis factor alpha-inducible protein 3 ( TNFAIP3 ) gene polymorphisms have recently been reported to be associated with the susceptibility to…”
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FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis by He, Siyuan, Li, Wanqian, Wang, Guoqing, Wang, Xiaotang, Fan, Wei, Zhang, Zhi, Li, Na, Hou, Shengping

“…Uveitis, a vision-threatening inflammatory disease worldwide, is closely related to resident microglia. Retinal microglia are the main immune effector cells…”
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