Search Results - "Hou, Kirk"

A role for peptides in overcoming endosomal entrapment in siRNA delivery — A focus on melittin by Hou, Kirk K., Pan, Hua, Schlesinger, Paul H., Wickline, Samuel A.

“…siRNA has the possibility to revolutionize medicine by enabling highly specific and efficient silencing of proteins involved in disease pathogenesis. Despite…”
Get full text

Peptide-Based Nanoparticles for Systemic Extrahepatic Delivery of Therapeutic Nucleotides by Wickline, Samuel A, Hou, Kirk K, Pan, Hua

“…Peptide-based nanoparticles (PBN) for nucleotide complexation and targeting of extrahepatic diseases are gaining recognition as potent pharmaceutical vehicles…”
Get full text

Mechanisms of Nanoparticle-Mediated siRNA Transfection by Melittin-Derived Peptides by Hou, Kirk K, Pan, Hua, Ratner, Lee, Schlesinger, Paul H, Wickline, Samuel A

“…Traditional peptide-mediated siRNA transfection via peptide transduction domains exhibits limited cytoplasmic delivery of siRNA due to endosomal entrapment…”
Get full text

Melittin derived peptides for nanoparticle based siRNA transfection by Hou, Kirk K, Pan, Hua, Lanza, Gregory M, Wickline, Samuel A

“…Abstract Traditional transfection agents including cationic lipids and polymers have high efficiency but cause cytotoxicity. While cell penetrating peptide…”
Get full text

Outcomes After Switching to Faricimab for Refractive Macular Edema in Treatment-Experienced Eyes with Neovascular Age-Related Macular Degeneration by Qaseem, Yaqoob, Hou, Kirk, Pettenkofer, Moritz

“…To examine response to faricimab in neovascular age-related macular degeneration (nARMD) refractory to traditional anti-vascular endothelial growth factor…”
Get full text

Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis by Zhou, Hui-fang, Yan, Huimin, Pan, Hua, Hou, Kirk K, Akk, Antonina, Springer, Luke E, Hu, Ying, Allen, J Stacy, Wickline, Samuel A, Pham, Christine T N

“…The NF-κB signaling pathway is implicated in various inflammatory diseases, including rheumatoid arthritis (RA); therefore, inhibition of this pathway has the…”
Get full text

CHRONIC HYPOTONY AND UVEITIS MANAGED WITH PARS PLANA VITRECTOMY, SILICONE OIL TAMPONADE, AND PERMANENT KERATOPROSTHESIS by Hou, Kirk K., Aldave, Anthony J., Kreiger, Allan E.

“…PURPOSEWe report a case of silicone oil placement after Boston Type 1 keratoprosthesis implantation for improvement and maintenance of intraocular pressure in…”
Get full text

An unusual presentation of peripapillary pachychoroid syndrome by Hubschman, Sasha, Hou, Kirk, Sarraf, David, Tsui, Irena

“…Peripapillary pachychoroid syndrome (PPS) is a recently described entity of the pachychoroid disease spectrum and is characterized by thickening of the nasal…”
Get full text

Probing the surface-enhanced Raman scattering properties of Au-Ag nanocages at two different excitation wavelengths by Rycenga, Matthew, Hou, Kirk K, Cobley, Claire M, Schwartz, Andrea G, Camargo, Pedro H C, Xia, Younan

“…The surface-enhanced Raman scattering (SERS) properties of bimetallic Au-Ag nanocages has been thoroughly investigated by changing the nanocage composition,…”
Get more information

Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice by Pan, Hua, Palekar, Rohun U, Hou, Kirk K, Bacon, John, Yan, Huimin, Springer, Luke E, Akk, Antonina, Yang, Lihua, Miller, Mark J, Pham, Christine Tn, Schlesinger, Paul H, Wickline, Samuel A

“…A direct and independent role of inflammation in atherothrombosis was recently highlighted by the Canakinumab Antiinflammatory Thrombosis Outcome Study…”
Get full text

The Polarity Protein Par1b/EMK/MARK2 Regulates T Cell Receptor-Induced Microtubule-Organizing Center Polarization by Lin, Joseph, Hou, Kirk K, Piwnica-Worms, Helen, Shaw, Andrey S

“…Engagement of a T cell to an APC induces the formation of an immunological synapse as well as reorientation of the microtubule-organizing center (MTOC) toward…”
Get full text

Pseudoflow with OCT Angiography in Eyes with Hard Exudates and Macular Drusen by Hou, Kirk K, Au, Adrian, Kashani, Amir H, Freund, K Bailey, Sadda, Srinivas R, Sarraf, David

“…To analyze "pseudoflow," a false positive flow-artifact observed with optical coherence tomography angiography (OCTA) of stationary hyperreflective structures…”
Get full text

Traumatic Retinal Detachment in Patients with Self-Injurious Behavior: An International Multicenter Study by Rossin, Elizabeth J, Tsui, Irena, Wong, Sui Chien, Hou, Kirk K, Prakhunhungsit, Supalert, Blair, Michael P, Shapiro, Michael J, Leishman, Lisa, Nagiel, Aaron, Lifton, Jacob A, Quiram, Polly, Ringeisen, Alexander L, Henderson, Robert H, Arruti, Natalia, Buzzacco, Dominic M, Kusaka, Shunji, Ferrone, Philip J, Belin, Peter J, Chang, Emmanuel, Hubschman, Jean-Pierre, Murray, Timothy G, Leung, Ella H, Wu, Wei-Chi, Olsen, Karl R, Harper, 3rd, C Armitage, Rahmani, Safa, Goldstein, Jessica, Lee, Thomas, Nudleman, Eric, Cernichiaro-Espinosa, Linda A, Chhablani, Jay, Berrocal, Audina M, Yonekawa, Yoshihiro

“…To describe the clinical characteristics, surgical outcomes, and management recommendations in patients with traumatic rhegmatogenous retinal detachment (RRD)…”
Get more information

RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honey bee by Li-Byarlay, Hongmei, Li, Yang, Stroud, Hume, Feng, Suhua, Newman, Thomas C., Kaneda, Megan, Hou, Kirk K., Worley, Kim C., Elsik, Christine G., Wickline, Samuel A., Jacobsen, Steven E., Ma, Jian, Robinson, Gene E.

“…Studies of DNA methylation from fungi, plants, and animals indicate that gene body methylation is ancient and highly conserved in eukaryotic genomes, but its…”
Get full text

A novel mellitin‐derived peptide nanoparticle delivery system for STAT3 siRNA mediated killing of B16 melanoma cells by Hou, Kirk, Wickline, Sam

“…Abstract only Exogenously delivered siRNA has the potential to form a new class of cancer therapeutics based on sequence specific silencing of oncogene…”
Get full text

Posterior Uveitis Associated with Cemiplimab by Dow, Eliot R., Hou, Kirk, Ransome, Susan, Abbassi, Sam, Tsui, Edmund

“…The immune checkpoint inhibitors (ICPIs) comprise a class of oncologic immunotherapies. The most recent US Food and Drug Administration-approved ICPI is…”
Get full text

Alterations of the foveal central bouquet associated with cystoid macular edema by Lenis, Tamara L., Au, Adrian, Hou, Kirk, Govetto, Andrea, Sarraf, David

“…The central bouquet (CB) of the fovea comprises a dense array of cone photoreceptors intertwined with Müller cells. The aim of this investigation was to study…”
Get full text

Volumetric Analysis of Vascularized Serous Pigment Epithelial Detachment Progression in Neovascular Age-Related Macular Degeneration Using Optical Coherence Tomography Angiography by Au, Adrian, Hou, Kirk, Dávila, Juan Pablo, Gunnemann, Frederic, Fragiotta, Serena, Arya, Malvika, Sacconi, Riccardo, Pauleikhoff, Daniel, Querques, Giuseppe, Waheed, Nadia, Freund, K Bailey, Sadda, SriniVas, Sarraf, David

“…To analyze the evolution of type 1 neovascularization associated with vascularized serous pigment epithelial detachment (vsPED) using three-dimensional,…”
Get full text

Application of a platform nanotechnology for anti‐NF‐kB siRNA delivery to metastatic melanoma by Pan, Hua, Hou, Kirk, Allen, Stacy, Scott, Mike, Wickline, Samuel

“…Abstract only…”
Get full text

Programmable nanoparticle functionalization for in vivo targeting by Pan, Hua, Myerson, Jacob W., Hu, Lingzhi, Marsh, Jon N., Hou, Kirk, Scott, Michael J., Allen, John S., Hu, Grace, Roman, Susana San, Lanza, Gregory M., Schreiber, Robert D., Schlesinger, Paul H., Wickline, Samuel A.

“…The emerging demand for programmable functionalization of existing base nanocarriers necessitates development of an efficient approach for cargo loading that…”
Get full text