Search Results - "Hou, Alicia"

CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors by Jin, Linchun, Tao, Haipeng, Karachi, Aida, Long, Yu, Hou, Alicia Y., Na, Meng, Dyson, Kyle A., Grippin, Adam J., Deleyrolle, Loic P., Zhang, Wang, Rajon, Didier A., Wang, Qiong J., Yang, James C., Kresak, Jesse L., Sayour, Elias J., Rahman, Maryam, Bova, Frank J., Lin, Zhiguo, Mitchell, Duane A., Huang, Jianping

“…Chimeric antigen receptor (CAR) T-cell therapy targeting solid tumors has stagnated as a result of tumor heterogeneity, immunosuppressive microenvironments,…”
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Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma by Long, Yu, Tao, Haipeng, Karachi, Aida, Grippin, Adam J, Jin, Linchun, Chang, Yifan Emily, Zhang, Wang, Dyson, Kyle A, Hou, Alicia Y, Na, Meng, Deleyrolle, Loic P, Sayour, Elias J, Rahman, Maryam, Mitchell, Duane A, Lin, Zhiguo, Huang, Jianping

“…Anti-VEGF therapy prolongs recurrence-free survival in patients with glioblastoma but does not improve overall survival. To address this discrepancy, we…”
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Differential DNA Methylation Profiles in Patients with Temporal Lobe Epilepsy and Hippocampal Sclerosis ILAE Type I by Zhang, Wang, Wang, Haiyang, Liu, Binchao, Jiang, Miaomiao, Gu, Yifei, Yan, Shi, Han, Xian, Hou, Alicia Y., Tang, Chongyang, Jiang, Zhenfeng, Shen, Hong, Na, Meng, Lin, Zhiguo

“…Hippocampal sclerosis (HS) is one of the most prevalent pathological types of temporal lobe epilepsy (TLE), and it significantly affects patient prognoses. The…”
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269 CAR T cell production expands endogenous T cell repertoire recognizing additional tumor antigen(s) by Hou, Alicia, Jin, Linchun, Tao, Haipeng, Mitchell, Duane A, Huang, Jianping

“…BackgroundGlioblastoma (GBM) is an aggressive and heterogeneous brain tumor that currently has no curative treatment. Our group identified CD70, which is…”
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Spatiotemporal Discharge Variability of the Doce River in SE Brazil During MIS 6 and 5 by Arndt, Iris, Voigt, Silke, Petschick, Rainer, Hou, Alicia, Raddatz, Jacek, Albuquerque, Ana Luiza S., Bahr, André

“…The modern precipitation balance in southeastern (SE) Brazil is regulated by the South American summer Monsoon and threatened by global climate change. On…”
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Forcing of western tropical South Atlantic sea surface temperature across three glacial-interglacial cycles by Hou, Alicia, Bahr, André, Schmidt, Stefan, Strebl, Cornelia, Albuquerque, Ana Luiza, Chiessi, Cristiano M., Friedrich, Oliver

“…The western tropical Atlantic (WTA) supplies warm and saline waters to the upper-limb of the Atlantic Meridional Overturning Circulation (AMOC) and may store…”
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Insolation and Greenhouse Gas Forcing of the South American Monsoon System Across Three Glacial‐Interglacial Cycles by Hou, Alicia, Bahr, André, Raddatz, Jacek, Voigt, Silke, Greule, Markus, Albuquerque, Ana Luiza, Chiessi, Cristiano M., Friedrich, Oliver

“…Precipitation extremes with devastating socioeconomic consequences within the South American Monsoon System (SAMS) are expected to become more frequent in the…”
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EXTH-57. IDENTIFICATION OF NOVEL IMMUNE CHECKPOINT MOLECULE IN GLIOMA, LAIR1 by Tao, Haipeng, Chen, Dongjiang, Yang, Changlin, Jin, Linchun, Von Roemeling, Christina, Mendez-Gomez, Hector, Liu, Ruixuan, Nguyen, Duy, Hou, Alicia Y, Pepe, Alfonso, Weidert, Frances, Ghiaseddin, Ashley, Mitchell, Duane, Deleyrolle, Loic, Sayour, Elias, Sawyer, W, Tran, David, Huang, Jianping

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Long-lived coralline alga records multidecadal variability in Labrador Sea carbon isotopes by Hou, A., Halfar, J., Adey, W., Wortmann, U.G., Zajacz, Z., Tsay, A., Williams, B., Chan, P.

“…While the recent decline in the δ13C composition of oceanic dissolved inorganic carbon (DIC) can be attributed to increasing anthropogenic CO2 emissions (13C…”
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EXTH-58. BLOCKING IMMUNE CHECKPOINT— LAIR1: DISRUPTING THE LAIR1—FXIII-A—COLLAGEN IMMUNOSUPPRESSIVE CIRCUIT FOR ENHANCED ANTITUMOR THERAPEUTICS by Tao, Haipeng, Chen, Dongjiang, Yang, Changlin, Nguyen, Duy T, Liu, Ruixuan, Liu, Tianyi, Chakraborty, Avirup, Hou, Alicia Y, Petit, Nicole A, Von Roemeling, Christina, Lin, Tuo, Davis, Robert W, Zhang, Janie, Pepe, Alfonso, Pedro, Diego Ivan, Mendez-Gomez, Hector, Weidert, Frances, Jin, Dan, Long-James, Kaytora, Castillo, Paul C, Ligon, John A, Ghiaseddin, Ashley, Sayour, Elias J, Rahman, Maryam, Deleyrolle, Loic P, Kim, Betty Y S, Mitchell, Duane A, Sawyer, W Gregory, Huang, Jianping

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IMMU-26. RADIATION AND TEMOZOLOMIDE UP-REGULATES CD70 EXPRESSION AND ENHANCES CAR T- CELL RECOGNITION IN GBM by Na, Meng, Jin, Linchun, Tao, Haipeng, Hou, Alicia, Karachi, Aida, Lin, Zhiguo, Deleyrolle, Loic, Sayour, Elias, Mitchell, Duane, Huang, Jianping

“…Abstract BACKGROUND Glioblastoma (GBM) is a recalcitrant brain cancer in the clinic. The therapeutic effect of using standard care (SC), such as surgery,…”
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IMMU-15. A UNIQUE SELF-STIMULATIVE PROPERTY OF CD70 CAR ADVANCES T CELL FUNCTION AND ANTI-TUMOR RESPONSE IN GLIOBLASTOMA by Jin, Linchun, Hou, Alicia, Tao, Haipeng, Karachi, Aida, Na, Meng, Lin, Zhiguo, Deleyrolle, Loic, Sayour, Elias, Mitchell, Duane, Huang, Jianping

“…Abstract BACKGROUND Glioblastoma (GBM) is a refractory brain tumor that desperately needs new therapeutic interventions. Our group identified CD70 as a novel…”
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EXTH-22. AN IND-ENABLED STUDY USING A NOVEL CHECKPOINT BLOCKADE OF LAIR1 FOR GLIOBLASTOMA THERAPY by Tao, Haipeng, Chen, Dongjiang, Yang, Changlin, Nguyen, Duy, Pepe, Alfonso, Pedro, Diego, Jin, Linchun, Liu, Ruixuan, Liu, Tianyi, Von Roemeling, Christina, Abbas, Muhammad, Hou, Alicia Y, Petit, Nicole, Abboud, Georges, Mendez-Gomez, Hector, Weidert, Frances, Jin, Dan, Long-James, Kaytora, Sayour, Elias, Deleyrolle, Loic, Gregory Sawyer, W, Mitchell, Duane, Huang, Jianping

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IMMU-38. PRECLINICAL VALIDATION AND MANUFACTURE OF IL-8 RECEPTOR-MODIFIED CD70 CAR T CELLS FOR CLINICAL TRIAL by Jin, Linchun, Tao, Haipeng, Karachi, Aida, Mendez-Gomez, Hector, Weidert, Frances, Hou, Alicia, Sayour, Elias, Mitchell, Duane, Huang, Jianping

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TMIC-49. ABROGATING CD70 EXPRESSION IN GBM RESULTS IN A REDUCED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT by Tao, Haipeng, Jin, Linchun, Mendez-Gomez, Hector, Long, Yu, Na, Meng, Hou, Alicia, Karachi, Aida, Lin, Zhiguo, Deleyrolle, Loic, Sayour, Elias, Mitchell, Duane, Huang, Jianping

“…Abstract BACKGROUND We found that CD70, as an immune modulator, in GBM plays a critical role in immunosuppression and tumor progression. Although CD70+ tumors…”
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Obliquity Influence on Low‐Latitude Coastal Precipitation in Eastern Brazil During the Past ∼850 kyr by Hou, Alicia, Bahr, André, Chiessi, Cristiano M., Jaeschke, Andrea, Albuquerque, Ana Luiza S., Pross, Jörg, Koutsodendris, Andreas, Friedrich, Oliver

“…Paleoclimate records from tropical South America typically show precession‐paced variability in rainfall, caused by insolation‐driven changes in the South…”
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