Search Results - "Hoth, Lise R."

Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue by Fadeyi, Olugbeminiyi O, Hoth, Lise R, Choi, Chulho, Feng, Xidong, Gopalsamy, Ariamala, Hett, Erik C, Kyne, Robert E, Robinson, Ralph P, Jones, Lyn H

“…Irreversible enzyme inhibitors and covalent chemical biology probes often utilize the reaction of a protein cysteine residue with an appropriately positioned…”
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Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators by Rajamohan, Francis, Reyes, Allan R, Frisbie, Richard K, Hoth, Lise R, Sahasrabudhe, Parag, Magyar, Rachelle, Landro, James A, Withka, Jane M, Caspers, Nicole L, Calabrese, Matthew F, Ward, Jessica, Kurumbail, Ravi G

“…AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that serves as a pleotropic regulator of whole body energy homoeostasis. AMPK exists…”
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Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies by Conrad, Karen S., Cheng, Ting-Wen, Ysselstein, Daniel, Heybrock, Saskia, Hoth, Lise R., Chrunyk, Boris A., am Ende, Christopher W., Krainc, Dimitri, Schwake, Michael, Saftig, Paul, Liu, Shenping, Qiu, Xiayang, Ehlers, Michael D.

“…Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) contributes to endosomal and lysosomal function. LIMP-2 deficiency is associated with neurological…”
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Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease[S] by Rajamohan, Francis, Reyes, Allan R., Tu, Meihua, Nedoma, Nicole L., Hoth, Lise R., Schwaid, Adam G., Kurumbail, Ravi G., Ward, Jessica, Han, Seungil

“…Lysosomal acid lipase (LAL) is a serine hydrolase that hydrolyzes cholesteryl ester (CE) and TGs delivered to the lysosomes into free cholesterol and fatty…”
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Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia by Mansour, Mahmoud N, Seddon, Andrew P, Hoth, Lise R, Xia, Donghui, Geoghegan, Kieran F, Griffor, Matthew C, Subashi, Timothy A, Shenolikar, Shirish, Danley, Dennis E, Ammirati, Mark J, McGrath, Katherine M, Culp, Jeffrey S, Hawkins, Julie L, Varghese, Alison H, Qiu, Xiayang, Warren, Laurie C, Cunningham, David, Stutzman-Engwall, Kim J

“…Proprotein convertase subtilisin kexin type 9 (PCSK9) lowers the abundance of surface low-density lipoprotein (LDL) receptor through an undefined mechanism…”
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A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification by Nolte, Whitney M, Fortin, Jean-Philippe, Stevens, Benjamin D, Aspnes, Gary E, Griffith, David A, Hoth, Lise R, Ruggeri, Roger B, Mathiowetz, Alan M, Limberakis, Chris, Hepworth, David, Carpino, Philip A

“…BETP, a positive allosteric modulator of GLP-1R, a class B GPCR and an important therapeutic target for type II diabetes, covalently modifies two cysteine…”
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Activation of AMP-Activated Protein Kinase Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry by Landgraf, Rachelle R., Goswami, Devrishi, Rajamohan, Francis, Harris, Melissa S., Calabrese, Matthew F., Hoth, Lise R., Magyar, Rachelle, Pascal, Bruce D., Chalmers, Michael J., Busby, Scott A., Kurumbail, Ravi G., Griffin, Patrick R.

“…AMP-activated protein kinase (AMPK) monitors cellular energy, regulates genes involved in ATP synthesis and consumption, and is allosterically activated by…”
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Expression and functional characterization of human lysosomal acid lipase gene (LIPA) mutation responsible for cholesteryl ester storage disease (CESD) phenotype by Rajamohan, Francis, Reyes, Allan R., Ruangsiriluk, Wanida, Hoth, Lise R., Han, Seungil, Caspers, Nicole, Tu, Meihua, Ward, Jessica, Kurumbail, Ravi G.

“…•Mutations in lysosomal acid lipase are associated with Wolman disease and CESD.•Patients homozygous for His295Tyr (H295Y) mutation have <5% of normal LAL…”
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Kinetic Analysis of Estrogen Receptor/Ligand Interactions by Rich, Rebecca L., Hoth, Lise R., Geoghegan, Kieran F., Brown, Thomas A., LeMotte, Peter K., Simons, Samuel P., Hensley, Preston, Myszka, David G.

“…Surface plasmon resonance biosensor technology was used to directly measure the binding interactions of small molecules to the ligand-binding domain of human…”
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Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides by Zhou, Hua, Mukherjee, Paramita, Liu, Rongqiang, Evrard, Edelweiss, Wang, Dianpeng, Humphrey, John M, Butler, Todd W, Hoth, Lise R, Sperry, Jeffrey B, Sakata, Sylvie K, Helal, Christopher J, am Ende, Christopher W

“…The design, synthesis, and application of [4-(acetylamino)­phenyl]­imidodisulfuryl difluoride (AISF), a shelf-stable, crystalline reagent for the synthesis of…”
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Crystal structures of interleukin 17A and its complex with IL-17 receptor A by Liu, Shenping, Song, Xi, Chrunyk, Boris A., Shanker, Suman, Hoth, Lise R., Marr, Eric S., Griffor, Matthew C.

“…The constituent polypeptides of the interleukin-17 family form six different homodimeric cytokines (IL-17A–F) and the heterodimeric IL-17A/F. Their…”
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Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms by Calabrese, Matthew F., Rajamohan, Francis, Harris, Melissa S., Caspers, Nicole L., Magyar, Rachelle, Withka, Jane M., Wang, Hong, Borzilleri, Kris A., Sahasrabudhe, Parag V., Hoth, Lise R., Geoghegan, Kieran F., Han, Seungil, Brown, Janice, Subashi, Timothy A., Reyes, Allan R., Frisbie, Richard K., Ward, Jessica, Miller, Russell A., Landro, James A., Londregan, Allyn T., Carpino, Philip A., Cabral, Shawn, Smith, Aaron C., Conn, Edward L., Cameron, Kimberly O., Qiu, Xiayang, Kurumbail, Ravi G.

“…AMP-activated protein kinase (AMPK) is a principal metabolic regulator affecting growth and response to cellular stress. Comprised of catalytic and regulatory…”
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Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists by Liu, Shenping, Dakin, Leslie A., Xing, Li, Withka, Jane M., Sahasrabudhe, Parag V., Li, Wei, Banker, Mary Ellen, Balbo, Paul, Shanker, Suman, Chrunyk, Boris A., Guo, Zuojun, Chen, Jinshan M., Young, Jennifer A., Bai, Guoyun, Starr, Jeremy T., Wright, Stephen W., Bussenius, Joerg, Tan, Sheng, Gopalsamy, Ariamala, Lefker, Bruce A., Vincent, Fabien, Jones, Lyn H., Xu, Hua, Hoth, Lise R., Geoghegan, Kieran F., Qiu, Xiayang, Bunnage, Mark E., Thorarensen, Atli

“…Interleukin-17A (IL-17A) is a principal driver of multiple inflammatory and immune disorders. Antibodies that neutralize IL-17A or its receptor (IL-17RA)…”
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Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules by Thompson, John F, Wang, Ing-Kae, Stutzman-Engwall, Kim J, Freeman, Thomas B, Chrunyk, Boris A, Hayward, Cheryl M, Ammirati, Mark J, Cong, Yang, Lloyd, David B, Subashi, Timothy A, Karam, George A, Hoth, Lise R, McGrath, Katherine M, Seddon, Andrew P, Lira, Maruja E, Mistry, Anil, Hawrylik, Steven J, Qiu, Xiayang, Geoghegan, Kieran F, Griffor, Matthew C, Hensley, Preston, Clark, Ronald W, Danley, Dennis E, Subashi, Ann K, Zhao, Honglei, Culp, Jeffrey S

“…Cholesteryl ester transfer protein (CETP) shuttles various lipids between lipoproteins, resulting in the net transfer of cholesteryl esters from…”
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Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system by Caspers, Nicole L., Han, Seungil, Rajamohan, Francis, Hoth, Lise R., Geoghegan, Kieran F., Subashi, Timothy A., Vazquez, Michael L., Kaila, Neelu, Cronin, Ciarán N., Johnson, Eric, Kurumbail, Ravi G.

“…Crystals of phosphorylated JAK1 kinase domain were initially generated in complex with nucleotide (ADP) and magnesium. The tightly bound Mg2+‐ADP at the…”
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Unexpected mucin-type O-glycosylation and host-specific N-glycosylation of human recombinant interleukin-17A expressed in a human kidney cell line by Geoghegan, Kieran F., Song, Xi, Hoth, Lise R., Feng, Xidong, Shanker, Suman, Quazi, Amira, Luxenberg, Deborah P., Wright, Jill F., Griffor, Matthew C.

“…► Human recombinant interleukin-17A expressed in HEK293 cells was variably glycosylated. ► Mass spectrometry was used to characterize its glycosylation. ► At…”
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Biophysical and Biochemical Approach to Locating an Inhibitor Binding Site on Cholesteryl Ester Transfer Protein by Cunningham, David, Lin, Wen, Hoth, Lise R, Danley, Dennis E, Ruggeri, Roger B, Geoghegan, Kieran F, Chrunyk, Boris A, Boyd, James G

“…Cholesteryl ester transfer protein (CETP) transfers neutral lipids between different types of plasma lipoprotein. Inhibitors of CETP elevate the fraction of…”
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Binding to the Low-Density Lipoprotein Receptor Accelerates Futile Catalytic Cycling in PCSK9 and Raises the Equilibrium Level of Intramolecular Acylenzyme by Geoghegan, Kieran F, Hoth, Lise R, Varghese, Alison H, Lin, Wen, Boyd, James G, Griffor, Matthew C

“…Proprotein convertase subtilisin-kexin type 9 (PCSK9) binds to the low-density lipoprotein receptor (LDLR) on target cells and lowers the level of receptor by…”
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Cyclization of N-Terminal S-Carbamoylmethylcysteine Causing Loss of 17 Da from Peptides and Extra Peaks in Peptide Maps by Geoghegan, Kieran F, Hoth, Lise R, Tan, Douglas H, Borzilleri, Kris A, Withka, Jane M, Boyd, James G

“…Enzymatic digests of proteins S-alkylated with iodoacetamide may contain peptides with N-terminal S-carbamoylmethylcysteine. These can be partly converted to a…”
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Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors by Letavic, Michael A., Axt, Matt Z., Barberia, John T., Carty, Thomas J., Danley, Dennis E., Geoghegan, Kieran F., Halim, Nadia S., Hoth, Lise R., Kamath, Ajith V., Laird, Ellen R., Lopresti-Morrow, Lori L., McClure, Kim F., Mitchell, Peter G., Natarajan, Vijayalakshmi, Noe, Mark C., Pandit, Jayvardhan, Reeves, Lisa, Schulte, Gayle K., Snow, Sheri L., Sweeney, Francis J., Tan, Douglas H., Yu, Chul H.

“…A series of novel, selective TNF-α converting enzyme inhibitors based on 4-hydroxy and 5-hydroxy pipecolate hydroxamic acid scaffolds is described. The potency…”
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