Search Results - "Hotamisligil, Gôkhan S."

Foundations of Immunometabolism and Implications for Metabolic Health and Disease by Hotamisligil, Gökhan S.

“…Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of…”
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Inflammation, metaflammation and immunometabolic disorders by Hotamisligil, Gökhan S.

“…Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to…”
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Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment by Ertunc, Meric Erikci, Hotamisligil, Gökhan S.

“…Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids, and triglycerides. These molecules represent a highly efficient…”
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Cell Signaling and Stress Responses by Hotamisligil, Gökhan S, Davis, Roger J

“…Stress-signaling pathways are evolutionarily conserved and play an important role in the maintenance of homeostasis. These pathways are also critical for…”
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Metabolic functions of FABPs—mechanisms and therapeutic implications by Hotamisligil, Gökhan S., Bernlohr, David A.

“…Key Points Fatty acid-binding proteins (FABPs) are versatile proteins that can modulate lipid fluxes, trafficking, signalling and metabolism Fatty acid-binding…”
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Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease by Hotamisligil, Gökhan S.

“…The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking and is central to many cellular functions. Failure of the ER's…”
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Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes by Arruda, Ana Paula, Hotamisligil, Gökhan S.

“…A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular disease, asthma, and cancer, cluster together to present the greatest…”
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Metabolic Messengers: tumour necrosis factor by Sethi, Jaswinder K., Hotamisligil, Gökhan S.

“…Tumour necrosis factor (TNF) is a classical, pleiotropic pro-inflammatory cytokine. It is also the first ‘adipokine’ described to be produced from adipose…”
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FABP4 Attenuates PPARγ and Adipogenesis and Is Inversely Correlated With PPARγ in Adipose Tissues by GARIN-SHKOLNIK, Tali, RUDICH, Assaf, HOTAMISLIGIL, Gökhan S, RUBINSTEIN, Menachem

“…Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and…”
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Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity by Arruda, Ana Paula, Pers, Benedicte M, Parlakgül, Güneş, Güney, Ekin, Inouye, Karen, Hotamisligil, Gökhan S

“…Obesity-induced mitochondria stress and dysfunction results from disorganized mitochondria-associated ER membranes and excess calcium flux. Proper function of…”
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Inflammatory mechanisms in obesity by Gregor, Margaret F, Hotamisligil, Gökhan S

“…The modern rise in obesity and its strong association with insulin resistance and type 2 diabetes have elicited interest in the underlying mechanisms of these…”
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Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes by Hummasti, Sarah, Hotamisligil, Gökhan S

“…Obesity is a major problem worldwide that increases risk for a wide range of diseases, including diabetes and heart disease. As such, it is increasingly…”
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The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling by Fu, Suneng, Watkins, Steven M., Hotamisligil, Gökhan S.

“…The endoplasmic reticulum (ER) is a critical site of protein, lipid, and glucose metabolism, lipoprotein secretion, and calcium homeostasis. Many of the…”
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Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss by GREGOR, Margaret F, LING YANG, FABBRINI, Elisa, MOHAMMED, B. Selma, EAGON, J. Christopher, HOTAMISLIGIL, Gökhan S, KLEIN, Samuel

“…Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss Margaret F. Gregor 1 , Ling Yang 1 , Elisa Fabbrini 2 , B. Selma…”
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Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses by Prentice, Kacey J., Saksi, Jani, Hotamisligil, Gökhan S.

“…Although counterregulatory hormones and mediators of the fight-or-flight responses are well defined at many levels, how energy stores per se are integrated…”
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Coordinated regulation of protein synthesis and degradation by mTORC1 by Zhang, Yinan, Nicholatos, Justin, Dreier, John R., Ricoult, Stéphane J. H., Widenmaier, Scott B., Hotamisligil, Gökhan S., Kwiatkowski, David J., Manning, Brendan D.

“…mTORC1 is known to stimulate protein synthesis; now, it is shown to also promote the synthesis of proteasomes, which degrade proteins into the amino acids…”
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Nutrient sensing and inflammation in metabolic diseases by Hotamisligil, Gökhan S, Erbay, Ebru

“…Key Points Mounting an immune response is a metabolically costly endeavour and cannot operate well under conditions of energy deficit. Energy surplus (for…”
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Inflammation and metabolic disorders by Hotamisligil, G.S

“…Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and…”
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The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue by Lynes, Matthew D, Leiria, Luiz O, Lundh, Morten, Bartelt, Alexander, Shamsi, Farnaz, Huang, Tian Lian, Takahashi, Hirokazu, Hirshman, Michael F, Schlein, Christian, Lee, Alexandra, Baer, Lisa A, May, Francis J, Gao, Fei, Narain, Niven R, Chen, Emily Y, Kiebish, Michael A, Cypess, Aaron M, Blüher, Matthias, Goodyear, Laurie J, Hotamisligil, Gökhan S, Stanford, Kristin I, Tseng, Yu-Hua

“…Cold stimulation induces the synthesis and release of the lipid species 12,13-diHOME from brown adipose tissue. This ‘lipokine’ then acts on brown adipocytes…”
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Endoplasmic reticulum stress and atherosclerosis by Hotamisligil, Gökhan S

“…Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention…”
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