Search Results - "Hostetter, Daniel"

Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index by Desnoyers, Luc R, Vasiljeva, Olga, Richardson, Jennifer H, Yang, Annie, Menendez, Elizabeth E M, Liang, Tony W, Wong, Chihunt, Bessette, Paul H, Kamath, Kathy, Moore, Stephen J, Sagert, Jason G, Hostetter, Daniel R, Han, Fei, Gee, Jason, Flandez, Jeanne, Markham, Kate, Nguyen, Margaret, Krimm, Michael, Wong, Kenneth R, Liu, Shouchun, Daugherty, Patrick S, West, James W, Lowman, Henry B

“…Target-mediated toxicity constitutes a major limitation for the development of therapeutic antibodies. To redirect the activity of antibodies recognizing…”
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Continuous Imaging of Plasmon Rulers in Live Cells Reveals Early-Stage Caspase-3 Activation at the Single-Molecule Level by Jun, Young-wook, Sheikholeslami, Sassan, Hostetter, Daniel R., Tajon, Cheryl, Craik, Charles S., Alivisatos, A. Paul

“…The use of plasmon coupling in metal nanoparticles has shown great potential for the optical characterization of many biological processes. Recently, we have…”
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Global identification of peptidase specificity by multiplex substrate profiling by O'Donoghue, Anthony J, Eroy-Reveles, A Alegra, Knudsen, Giselle M, Ingram, Jessica, Zhou, Min, Statnekov, Jacob B, Greninger, Alexander L, Hostetter, Daniel R, Qu, Gang, Maltby, David A, Anderson, Marc O, DeRisi, Joseph L, McKerrow, James H, Burlingame, Alma L, Craik, Charles S

“…A synthetic peptide library in conjunction with liquid chromatography–tandem mass spectrometry identifies the specificities of endo- and exopeptidases without…”
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Antagonistic Anti-urokinase Plasminogen Activator Receptor (uPAR) Antibodies Significantly Inhibit uPAR-mediated Cellular Signaling and Migration by Duriseti, Sai, Goetz, David H., Hostetter, Daniel R., LeBeau, Aaron M., Wei, Ying, Craik, Charles S.

“…Interactions between urokinase plasminogen activator receptor (uPAR) and its various ligands regulate tumor growth, invasion, and metastasis. Antibodies that…”
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Prediction of protease substrates using sequence and structure features by Barkan, David T., Hostetter, Daniel R., Mahrus, Sami, Pieper, Ursula, Wells, James A., Craik, Charles S., Sali, Andrej

“…Motivation:Granzyme B (GrB) and caspases cleave specific protein substrates to induce apoptosis in virally infected and neoplastic cells. While substrates for…”
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Human and mouse granzyme M display divergent and species-specific substrate specificities by de Poot, Stefanie A H, Westgeest, Marijn, Hostetter, Daniel R, Van Damme, Petra, Plasman, Kim, Demeyer, Kimberly, Broekhuizen, Roel, Gevaert, Kris, Craik, Charles S, Bovenschen, Niels

“…Cytotoxic lymphocyte protease GrM (granzyme M) is a potent inducer of tumour cell death and a key regulator of inflammation. Although hGrM (human GrM) and mGrM…”
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The myosin coiled-coil is a truly elastic protein structure by Rief, Matthias, Schwaiger, Ingo, Sattler, Clara, Hostetter, Daniel R

“…Coiled-coils occur in a variety of proteins involved in mechanical and structural tasks in the cell. Their mechanical properties are important in various…”
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Imaging active urokinase plasminogen activator in prostate cancer by LeBeau, Aaron M, Sevillano, Natalia, Markham, Kate, Winter, Michael B, Murphy, Stephanie T, Hostetter, Daniel R, West, James, Lowman, Henry, Craik, Charles S, VanBrocklin, Henry F

“…The increased proteolytic activity of membrane-bound and secreted proteases on the surface of cancer cells and in the transformed stroma is a common…”
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Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors by O'Donoghue, Anthony J, Ivry, Sam L, Chaudhury, Chaity, Hostetter, Daniel R, Hanahan, Douglas, Craik, Charles S

“…The cathepsin family of lysosomal proteases is increasingly being recognized for their altered expression in cancer and role in facilitating tumor progression…”
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Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis by Ray, Manisha, Hostetter, Daniel R., Loeb, Carly R.K., Simko, Jeffry, Craik, Charles S.

“…BACKGROUND In order for tumors to grow and proliferate, they must avoid recognition by immune cells and subsequent death by apoptosis. Granzyme B (GrB), a…”
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133 CRISPR/Cas9 gene-edited allogeneic CAR-T cells targeting CD33 show high preclinical efficacy against AML without long-term hematopoietic toxicity by Terrett, Jonathan, Mcewan, Brigid, Hostetter, Daniel, Gamboa, Luis, Kuppuraju, Meghna, Ghonime, Mohammed, Chain, Robert, Padalia, Zinkal, Kalaitzidis, Demetrios

“…BackgroundCD33 is the most consistently expressed antigen in AML, with high levels and homogeneous expression observed in malignant AML cells from most…”
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Hip Is a Pro-survival Substrate of Granzyme B by Hostetter, Daniel R., Loeb, Carly R.K., Chu, Feixia, Craik, Charles S.

“…The extended substrate specificity of granzyme B (GrB) was used to identify substrates among the chaperone superfamily. This approach identified Hsp90 and…”
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Optical Imaging of Cellular Immunotherapy against Prostate Cancer by Tavri, Sidhartha, Jha, Priyanka, Meier, Reinhard, Henning, Tobias D., Müller, Tina, Hostetter, Daniel, Knopp, Christiane, Johansson, Magnus, Reinhart, Verena, Boddington, Sophie, Sista, Akhilesh, Wels, Winfried S., Daldrup-Link, Heike E.

“…The purpose of this study was to track fluorophore-labeled, tumor-targeted natural killer (NK) cells to human prostate cancer xenografts with optical imaging…”
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Dictyostelium myosin bipolar thick filament formation: importance of charge and specific domains of the myosin rod by Hostetter, Daniel, Rice, Sarah, Dean, Sara, Altman, David, McMahon, Peggy M, Sutton, Shirley, Tripathy, Ashutosh, Spudich, James A

“…Myosin-II thick filament formation in Dictyostelium is an excellent system for investigating the phenomenon of self-assembly, as the myosin molecule itself…”
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Temperature dependence of myosin-II tail fragment assembly by McMahon, Peggy M., Hostetter, Daniel R., Rice, Sarah E.

“…Dictyostelium myosin-II bipolar thick filament (BTF) assembly is heavily dependent on ionic strength and temperature and is reversible by the phosphorylation…”
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Correction: Dictyostelium Myosin Bipolar Thick Filament Formation: Importance of Charge and Specific Domains of the Myosin Rod by Hostetter, Daniel, Rice, Sarah, Dean, Sara, Altman, David, McMahon, Peggy M, Sutton, Shirley, Tripathy, Ashutosh, Spudich, James A

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367 CRISPR/Cas9 gene-edited, allogeneic anti-CD83 CAR-T cells demonstrate potent activity in GvHD and AML tumor models by Oumzil, Ismael, Guerrero, Valerie, Keerthipati, Pooja Smruthi, Colangelo, Jaqlyn, Lawler, Brendan, Singson, Victoria, Khedkar, Aditya, Singh, Shweta, Terrett, Jonathan, Hostetter, Daniel

“…BackgroundCD83 is expressed on blood cancer cells, including acute myeloid leukemia (AML) blasts, and on allo-activated immune cells that are implicated in…”
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Monitoring of Natural Killer Cell Immunotherapy Using Noninvasive Imaging Modalities by JHA, Priyanka, GOLOVKO, Daniel, BAINS, Sukhmine, HOSTETTER, Daniel, MEIER, Reinhard, WENDLAND, Michael F, DALDRUP-LINK, Heike E

“…Cancer immunotherapies can be guided by cellular imaging techniques, which can identify the presence or absence of immune cell accumulation in the tumor tissue…”
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Abstract A203: CD3-EGFR bispecific Probody™ therapeutics induced tumor regressions and increased therapeutic window in preclinical studies by LaPorte, Sherry L., Hostetter, Daniel R., Wong, Laurie, Razo, Jennifer, Diep, Linnea, White, Clayton W., Richardson, Jennifer H., Kavanaugh, W. Michael, Irving, Bryan A.

“…Abstract T cell-engaging bispecific antibodies (TCBs) represent a highly potent modality to direct the activity of cytotoxic T cells to tumors. TCBs are…”
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Abstract 4570: Development of a proteolytically activatable EGFR Probody for cancer therapy by Desnoyers, Luc R., Yang, Annie, Liang, Tony W., Moore, Stephen, Sagert, Jason, Hostetter, Daniel R., Menendez, Elizabeth, Han, Fei, Krimm, Michael, Wong, Ken, Richardson, Jennifer, West, Jim W., Liu, Shouchun, Vasiljeva, Olga, Lowman, Henry B.

“…Abstract Antibodies directed to specific disease-related antigens have proven to be very successful therapeutics for a variety of disease indications. In spite…”
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