Search Results - "Hosp, Fabian"

A Primer on Concepts and Applications of Proteomics in Neuroscience by Hosp, Fabian, Mann, Matthias

“…The enormous complexity of the central nervous system has impeded its systemic exploration for decades but powerful “omic” technologies are now pushing forward…”
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Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors by Kim, Yujin E., Hosp, Fabian, Frottin, Frédéric, Ge, Hui, Mann, Matthias, Hayer-Hartl, Manajit, Hartl, F. Ulrich

“…Huntington’s disease is one of several neurodegenerative disorders characterized by the aggregation of polyglutamine (polyQ)-expanded mutant protein. How polyQ…”
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Cortical circuit alterations precede motor impairments in Huntington’s disease mice by Burgold, Johanna, Schulz-Trieglaff, Elena Katharina, Voelkl, Kerstin, Gutiérrez-Ángel, Sara, Bader, Jakob Maximilian, Hosp, Fabian, Mann, Matthias, Arzberger, Thomas, Klein, Rüdiger, Liebscher, Sabine, Dudanova, Irina

“…Huntington’s disease (HD) is a devastating hereditary movement disorder, characterized by degeneration of neurons in the striatum and cortex. Studies in human…”
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Spatiotemporal Proteomic Profiling of Huntington’s Disease Inclusions Reveals Widespread Loss of Protein Function by Hosp, Fabian, Gutiérrez-Ángel, Sara, Schaefer, Martin H., Cox, Jürgen, Meissner, Felix, Hipp, Mark S., Hartl, F.-Ulrich, Klein, Rüdiger, Dudanova, Irina, Mann, Matthias

“…Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington’s disease (HD) proceeds from soluble oligomers to late-stage inclusions. The…”
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Lysine acetylation in mitochondria: From inventory to function by Hosp, Fabian, Lassowskat, Ines, Santoro, Valeria, De Vleesschauwer, David, Fliegner, Daniela, Redestig, Henning, Mann, Matthias, Christian, Sven, Hannah, Matthew A, Finkemeier, Iris

“…Cellular signaling pathways are regulated in a highly dynamic fashion in order to quickly adapt to distinct environmental conditions. Acetylation of lysine…”
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Structure and Function of the Hetero-oligomeric Cysteine Synthase Complex in Plants by Wirtz, Markus, Birke, Hannah, Heeg, Corinna, Müller, Christopher, Hosp, Fabian, Throm, Christian, König, Stephan, Feldman-Salit, Anna, Rippe, Karsten, Petersen, Gabriele, Wade, Rebecca C., Rybin, Vladimir, Scheffzek, Klaus, Hell, Rüdiger

“…Cysteine synthesis in bacteria and plants is catalyzed by serine acetyltransferase (SAT) and O-acetylserine (thiol)-lyase (OAS-TL), which form the…”
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Novel Multidimensional Liquid Chromatography Workflow with In-Loop Enzymatic Digests of Multiple Heart-Cuts for Fast and Flexible Characterization of Biotherapeutic Protein Variants by Mayr, Kilian, Weindl, Thomas, Gärtner, Achim, Camperi, Julien, Maetzke, Thomas, Förster, Markus, Nachtigall, Thomas, Steiner, Frank, Vogt, Annette, Hosp, Fabian, Mølhøj, Michael

“…Multidimensional liquid chromatography (mD-LC) is becoming a powerful tool for complete characterization of individual peaks and protein variants through…”
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Dimethyl-Labeling-Based Quantification of the Lysine Acetylome and Proteome of Plants by Lassowskat, Ines, Hartl, Markus, Hosp, Fabian, Boersema, Paul J, Mann, Matthias, Finkemeier, Iris

“…Photorespiratory enzymes in different cellular compartments have been reported to be posttranslational modified by phosphorylation, disulfide formation,…”
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A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function by Kälin, Stefanie, Becker, Maike, Ott, Verena B., Serr, Isabelle, Hosp, Fabian, Mollah, Mohammad M.H., Keipert, Susanne, Lamp, Daniel, Rohner-Jeanrenaud, Francoise, Flynn, Victoria K., Scherm, Martin G., Nascimento, Lucas F.R., Gerlach, Katharina, Popp, Vanessa, Dietzen, Sarah, Bopp, Tobias, Krishnamurthy, Purna, Kaplan, Mark H., Serrano, Manuel, Woods, Stephen C., Tripal, Philipp, Palmisano, Ralf, Jastroch, Martin, Blüher, Matthias, Wolfrum, Christian, Weigmann, Benno, Ziegler, Anette-Gabriele, Mann, Matthias, Tschöp, Matthias H., Daniel, Carolin

“…Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3+ regulatory T cells (Tregs) control tissue homeostasis…”
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Systematic mapping of mitochondrial calcium uniporter channel (MCUC)-mediated calcium signaling networks by Delgado de la Herran, Hilda, Vecellio Reane, Denis, Cheng, Yiming, Katona, Máté, Hosp, Fabian, Greotti, Elisa, Wettmarshausen, Jennifer, Patron, Maria, Mohr, Hermine, Prudente de Mello, Natalia, Chudenkova, Margarita, Gorza, Matteo, Walia, Safal, Feng, Michael Sheng-Fu, Leimpek, Anja, Mielenz, Dirk, Pellegata, Natalia S, Langer, Thomas, Hajnóczky, György, Mann, Matthias, Murgia, Marta, Perocchi, Fabiana

“…The mitochondrial calcium uniporter channel (MCUC) mediates mitochondrial calcium entry, regulating energy metabolism and cell death. Although several MCUC…”
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A Double-Barrel Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) System to Quantify 96 Interactomes per Day by Hosp, Fabian, Scheltema, Richard A., Eberl, H. Christian, Kulak, Nils A., Keilhauer, Eva C., Mayr, Korbinian, Mann, Matthias

“…The field of proteomics has evolved hand-in-hand with technological advances in LC-MS/MS systems, now enabling the analysis of very deep proteomes in a…”
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Analyzing protein–protein interactions by quantitative mass spectrometry by Paul, Florian E., Hosp, Fabian, Selbach, Matthias

“…Since most cellular processes depend on interactions between proteins, information about protein–protein interactions (PPIs) provide valuable insights into…”
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A Stat6/Pten axis links cold exposure with T cell tolerance in adipose tissue by Kälin, Stefanie, Becker, Maike, Ott, Verena B., Serr, Isabelle, Hosp, Fabian, Mollah, Mohammad M. H., Keipert, Susanne, Lamp, Daniel, Rohner-Jeanrenaud, Francoise, Flynn, Victoria K., Scherm, Martin G., Nascimento, Lucas F. R., Gerlach, Katharina, Popp, Vanessa, Dietzen, Sarah, Bopp, Tobias, Krishnamurthy, Purna, Kaplan, Mark H., Serrano, Manuel, Woods, Stephen C., Tripal, Philipp, Palmisano, Ralf, Jastroch, Martin, Blüher, Matthias, Wolfrum, Christian, Weigmann, Benno, Ziegler, Anette-Gabriele, Mann, Matthias, Tschöp, Matthias H., Daniel, Carolin

“…Obesity and type-2 diabetes are associated with tissue-inflammation and metabolic defects in fat depots. Foxp3 + regulatory T(Treg) cells mediate T-cell…”
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Proteomic Analysis of Mitotic RNA Polymerase II Reveals Novel Interactors and Association With Proteins Dysfunctional in Disease by Möller, André, Xie, Sheila Q., Hosp, Fabian, Lang, Benjamin, Phatnani, Hemali P., James, Sonya, Ramirez, Francisco, Collin, Gayle B., Naggert, Jürgen K., Babu, M. Madan, Greenleaf, Arno L., Selbach, Matthias, Pombo, Ana

“…RNA polymerase II (RNAPII) transcribes protein-coding genes in eukaryotes and interacts with factors involved in chromatin remodeling, transcriptional…”
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