Search Results - "Hosomi, Koji"

Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity by Yoshii, Ken, Hosomi, Koji, Sawane, Kento, Kunisawa, Jun

“…Vitamins are micronutrients that have physiological effects on various biological responses, including host immunity. Therefore, vitamin deficiency leads to…”
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Diversity of energy metabolism in immune responses regulated by micro-organisms and dietary nutrition by Hosomi, Koji, Kunisawa, Jun

“…Abstract Immune metabolism has been recognized as a new paradigm in the regulation of host immunity. In the environment, there are many micro-organisms…”
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Impact of the intestinal environment on the immune responses to vaccination by Hosomi, Koji, Kunisawa, Jun

“…Vaccination has contributed greatly to the control of infectious diseases; however, regional and individual differences are occasionally observed in the…”
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Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota by Hosomi, Koji, Saito, Mayu, Park, Jonguk, Murakami, Haruka, Shibata, Naoko, Ando, Masahiro, Nagatake, Takahiro, Konishi, Kana, Ohno, Harumi, Tanisawa, Kumpei, Mohsen, Attayeb, Chen, Yi-An, Kawashima, Hitoshi, Natsume-Kitatani, Yayoi, Oka, Yoshimasa, Shimizu, Hidenori, Furuta, Mari, Tojima, Yoko, Sawane, Kento, Saika, Azusa, Kondo, Saki, Yonejima, Yasunori, Takeyama, Haruko, Matsutani, Akira, Mizuguchi, Kenji, Miyachi, Motohiko, Kunisawa, Jun

“…The gut microbiome is an important determinant in various diseases. Here we perform a cross-sectional study of Japanese adults and identify the Blautia genus,…”
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Utilization of gut environment-mediated control system of host immunity in the development of vaccine adjuvants by Liu, Zilai, Hosomi, Koji, Kunisawa, Jun

“…Vaccination is one of the most powerful strategies for the preventive and therapeutic control of infectious diseases and other diseases such as cancer. To…”
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Fatty acid metabolism in the host and commensal bacteria for the control of intestinal immune responses and diseases by Hosomi, Koji, Kiyono, Hiroshi, Kunisawa, Jun

“…Intestinal tissue has a specialized immune system that exhibits an exquisite balance between active and suppressive responses important for the maintenance of…”
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12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice by Nagatake, Takahiro, Shibata, Yuki, Morimoto, Sakiko, Node, Eri, Sawane, Kento, Hirata, So-ichiro, Adachi, Jun, Abe, Yuichi, Isoyama, Junko, Saika, Azusa, Hosomi, Koji, Tomonaga, Takeshi, Kunisawa, Jun

“…Atherosclerosis is a chronic inflammatory disease associated with macrophage aggregate and transformation into foam cells. In this study, we sought to…”
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Induction of unique macrophage subset by simultaneous stimulation with LPS and IL-4 by Ishida, Kei, Nagatake, Takahiro, Saika, Azusa, Kawai, Soichiro, Node, Eri, Hosomi, Koji, Kunisawa, Jun

“…Macrophages manifest as various subtypes that play diverse and important roles in immunosurveillance and the maintenance of immunological homeostasis in…”
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Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs by Tabata, Tokiko, Yamashita, Tomoya, Hosomi, Koji, Park, Jonguk, Hayashi, Tomohiro, Yoshida, Naofumi, Saito, Yoshihiro, Fukuzawa, Koji, Konishi, Kana, Murakami, Haruka, Kawashima, Hitoshi, Mizuguchi, Kenji, Miyachi, Motohiko, Kunisawa, Jun, Hirata, Ken-ichi

“…Atrial fibrillation (AF) reduces the quality of life by triggering stroke and heart failure. The association between AF onset and gut metabolites suggests a…”
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Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue by Sun, Xiao, Hosomi, Koji, Shimoyama, Atsushi, Yoshii, Ken, Saika, Azusa, Yamaura, Haruki, Nagatake, Takahiro, Kiyono, Hiroshi, Fukase, Koichi, Kunisawa, Jun

“…Abstract We previously demonstrated that Alcaligenes-derived lipid A (ALA), which is produced from an intestinal lymphoid tissue-resident commensal bacterium,…”
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Lipopolysaccharide from Gut‐Associated Lymphoid‐Tissue‐Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A by Shimoyama, Atsushi, Di Lorenzo, Flaviana, Yamaura, Haruki, Mizote, Keisuke, Palmigiano, Angelo, Pither, Molly D., Speciale, Immacolata, Uto, Tomoya, Masui, Seiji, Sturiale, Luisa, Garozzo, Domenico, Hosomi, Koji, Shibata, Naoko, Kabayama, Kazuya, Fujimoto, Yukari, Silipo, Alba, Kunisawa, Jun, Kiyono, Hiroshi, Molinaro, Antonio, Fukase, Koichi

“…Alcaligenes faecalis is the predominant Gram‐negative bacterium inhabiting gut‐associated lymphoid tissues, Peyer's patches. We previously reported that an A…”
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Impaired mucociliary motility enhances antigen-specific nasal IgA immune responses to a cholera toxin-based nasal vaccine by Lan, Huangwenxian, Suzuki, Hidehiko, Nagatake, Takahiro, Hosomi, Koji, Ikegami, Koji, Setou, Mitsutoshi, Kunisawa, Jun

“…Abstract Nasal mucosal tissues are equipped with physical barriers, mucus and cilia, on their surface. The mucus layer captures inhaled materials, and the…”
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Comprehensive analysis of gut microbiota of a healthy population and covariates affecting microbial variation in two large Japanese cohorts by Park, Jonguk, Kato, Kumiko, Murakami, Haruka, Hosomi, Koji, Tanisawa, Kumpei, Nakagata, Takashi, Ohno, Harumi, Konishi, Kana, Kawashima, Hitoshi, Chen, Yi-An, Mohsen, Attayeb, Xiao, Jin-Zhong, Odamaki, Toshitaka, Kunisawa, Jun, Mizuguchi, Kenji, Miyachi, Motohiko

“…Inter-individual variations in gut microbiota composition are observed even among healthy populations. The gut microbiota may exhibit a unique composition…”
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Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan by Iwasaki, Motoki, Kanehara, Rieko, Yamaji, Taiki, Katagiri, Ryoko, Mutoh, Michihiro, Tsunematsu, Yuta, Sato, Michio, Watanabe, Kenji, Hosomi, Koji, Kakugawa, Yasuo, Ikematsu, Hiroaki, Hotta, Kinichi, Kunisawa, Jun, Wakabayashi, Keiji, Matsuda, Takahisa

“…Escherichia coli containing polyketide synthase in the gut microbiota (pks+ E coli) produce a polyketide‐peptide genotoxin, colibactin, and are suspected to…”
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Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity by Hosomi, Koji, Ohno, Harumi, Murakami, Haruka, Natsume-Kitatani, Yayoi, Tanisawa, Kumpei, Hirata, Soichiro, Suzuki, Hidehiko, Nagatake, Takahiro, Nishino, Tomomi, Mizuguchi, Kenji, Miyachi, Motohiko, Kunisawa, Jun

“…Metagenomic analysis based on the 16S rRNA gene is generally performed to examine the diversity and abundance of commensal bacteria in feces, which is now…”
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Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice by Sawane, Kento, Nagatake, Takahiro, Hosomi, Koji, Hirata, So-Ichiro, Adachi, Jun, Abe, Yuichi, Isoyama, Junko, Suzuki, Hidehiko, Matsunaga, Ayu, Fukumitsu, Satoshi, Aida, Kazuhiko, Tomonaga, Takeshi, Arita, Makoto, Kunisawa, Jun

“…The metabolism and generation of bioactive lipid mediators are key events in the exertion of the beneficial effects of dietary omega-3 fatty acids in the…”
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Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition by Sato, Emiko, Hosomi, Koji, Sekimoto, Akiyo, Mishima, Eikan, Oe, Yuji, Saigusa, Daisuke, Ito, Sadayoshi, Abe, Takaaki, Sato, Hiroshi, Kunisawa, Jun, Niwa, Toshimitsu, Takahashi, Nobuyuki

“…In chronic kidney disease, elevated levels of circulating uremic toxins are associated with a variety of symptoms and organ dysfunction. Indoxyl sulfate (IS)…”
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Development of Adjuvant-Free Bivalent Food Poisoning Vaccine by Augmenting the Antigenicity of Clostridium perfringens Enterotoxin by Suzuki, Hidehiko, Hosomi, Koji, Nasu, Ayaka, Kondoh, Masuo, Kunisawa, Jun

“…enterotoxin (CPE) is a common cause of food poisoning and hyperkalemia-associated death. Previously, we reported that fusion of pneumococcal surface protein A…”
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Group X phospholipase A2 links colonic lipid homeostasis to systemic metabolism via host-microbiota interaction by Sato, Hiroyasu, Taketomi, Yoshitaka, Murase, Remi, Park, Jonguk, Hosomi, Koji, Sanada, Takayuki Jujo, Mizuguchi, Kenji, Arita, Makoto, Kunisawa, Jun, Murakami, Makoto

“…The gut microbiota influences physiological functions of the host, ranging from the maintenance of local gut homeostasis to systemic immunity and metabolism…”
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Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria by Tsunematsu, Yuta, Hosomi, Koji, Kunisawa, Jun, Sato, Michio, Shibuya, Noriko, Saito, Emiko, Murakami, Haruka, Yoshikawa, Yuko, Iwashita, Yuji, Miyoshi, Noriyuki, Mutoh, Michihiro, Ishikawa, Hideki, Sugimura, Haruhiko, Miyachi, Motohiko, Wakabayashi, Keiji, Watanabe, Kenji

“…The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore,…”
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