Search Results - "Hosogai, Naomi"

Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation by HOSOGAI, Naomi, FUKUHARA, Atsunori, SHIMOMURA, Iichiro, OSHIMA, Kazuya, MIYATA, Yugo, TANAKA, Sachiyo, SEGAWA, Katsumori, FURUKAWA, Shigetada, TOCHINO, Yoshihiro, KOMURO, Ryutaro, MATSUDA, Morihiro

“…Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation Naomi Hosogai , Atsunori Fukuhara , Kazuya Oshima , Yugo Miyata , Sachiyo…”
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FK614, a Novel Peroxisome Proliferator-Activated Receptor γ Modulator, Induces Differential Transactivation Through a Unique Ligand-Specific Interaction With Transcriptional Coactivators by Fujimura, Takao, Sakuma, Hiroyuki, Konishi, Satoko, Oe, Tomoya, Hosogai, Naomi, Kimura, Chiaki, Aramori, Ichiro, Mutoh, Seitaro

“…Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-dependent transcriptional factor implicated in regulating adipogenesis, glucose homeostasis,…”
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Visfatin in adipocytes is upregulated by hypoxia through HIF1α-dependent mechanism by Segawa, Katsumori, Fukuhara, Atsunori, Hosogai, Naomi, Morita, Kentaro, Okuno, Yosuke, Tanaka, Masaki, Nakagawa, Yasuhiko, Kihara, Shinji, Funahashi, Tohru, Komuro, Ryutaro, Matsuda, Morihiro, Shimomura, Iichiro

“…Obesity is associated with metabolic disorders, such as insulin resistance. Visfatin is an adipose-derived secretory factor to exert insulin-mimetic effects…”
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Synthesis and Characterization of Orally Active Nonpeptide Vasopressin V2 Receptor Antagonists by OHKAWA, Takehiko, ZENKOH, Tatsuya, TOMITA, Masayuki, HOSOGAI, Naomi, HEMMI, Keiji, TANAKA, Hirokazu, SETOI, Hiroyuki

“…The present study was undertaken to evaluate whether a novel series of 2, 6-diaza-5-oxobicyclo[5.4.0]undeca-1(7), 8, 10-triene derivatives exhibited…”
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Nitric oxide dysregulates adipocytokine expression in 3T3-L1 adipocytes by Nozaki, Maiko, Fukuhara, Atsunori, Segawa, Katsumori, Okuno, Yosuke, Abe, Manabu, Hosogai, Naomi, Matsuda, Morihiro, Komuro, Ryutaro, Shimomura, Iichiro

“…Obesity is associated with infiltration of macrophages into adipose tissue, and macrophages are an important source of nitric oxide (NO). Dysregulated…”
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Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism by Segawa, Katsumori, Fukuhara, Atsunori, Hosogai, Naomi, Morita, Kentaro, Okuno, Yosuke, Tanaka, Masaki, Nakagawa, Yasuhiko, Kihara, Shinji, Funahashi, Tohru, Komuro, Ryutaro, Matsuda, Morihiro, Shimomura, Iichiro

“…Obesity is associated with metabolic disorders, such as insulin resistance. Visfatin is an adipose-derived secretory factor to exert insulin-mimetic effects…”
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Enzyme activities of the nitric oxide–cGMP pathway in corpus cavernosum isolated from middle-aged rats by Hosogai, Naomi, Takakura, Shoji, Manda, Toshitaka, Mutoh, Seitaro

“…Cyclic guanosine-3′,5′-monophosphate (cGMP)-mediated mechanisms play an important role in vasodilation and blood pressure regulation. We investigated basal…”
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Phosphodiesterase type 5 inhibition ameliorates nephrotoxicity induced by cyclosporin A in spontaneous hypertensive rats by Hosogai, Naomi, Tomita, Masayuki, Hamada, Kaori, Ogawa, Toshikazu, Hirosumi, Jiro, Manda, Toshitaka, Mutoh, Seitaro

“…Our recent study suggests that there is a reciprocal mechanism to maintain cGMP content, via both a decrease in cGMP degradation (decrease in…”
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Reciprocal regulation of cyclic GMP content by cyclic GMP‐phosphodiesterase and guanylate cyclase in SHR with CsA‐induced nephrotoxicity by Hosogai, Naomi, Seki, Jiro, Goto, Toshio

“…The effect of the immunosuppressant drug, cyclosporin A (CsA), on the nitric oxide (NO)‐cyclic GMP pathway was examined in spontaneous hypertensive rats (SHR)…”
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FR226807: a potent and selective phosphodiesterase type 5 inhibitor by Hosogai, Naomi, Hamada, Kaori, Tomita, Masayuki, Nagashima, Akira, Takahashi, Tokiko, Sekizawa, Toshihiro, Mizutani, Tsuyoshi, Urano, Yasuharu, Kuroda, Akio, Sawada, Kozo, Ozaki, Tohru, Seki, Jiro, Goto, Toshio

“…We describe the pharmacological characteristics of a novel phosphodiesterase type 5 inhibitor FR226807, N-(3,4-dimethoxybenzyl)-2-{[(1…”
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Effect of FR226807, a selective phosphodiesterase 5 inhibitor, on the attenuated responsiveness of the corpus cavernosum in middle-aged and streptozotocin-induced diabetic rats by Naomi Hosogai, Tohru Ozaki, Jiro Seki, Toshio Goto

“…FR226807 (FR), a selective phosphodiesterase (PDE) 5 inhibitor (IC50； 71 μM： PDE1, 11 μM： PDE2, 5.4 μM： PDE3, 8.6 μM： PDE4 and 1.1 nM： PDE5), was evaluated in…”
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