Search Results - "Hosogai, N"

Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2 by Suwa, A, Yamamoto, T, Sawada, A, Minoura, K, Hosogai, N, Tahara, A, Kurama, T, Shimokawa, T, Aramori, I

“…Background and purpose:  The lipid phosphatase known as SH2 domain‐containing inositol 5′‐phosphatase 2 (SHIP2) plays an important role in the regulation of…”
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Enzyme activities of the nitric oxide–cGMP pathway in corpus cavernosum isolated from middle-aged rats by Hosogai, Naomi, Takakura, Shoji, Manda, Toshitaka, Mutoh, Seitaro

“…Cyclic guanosine-3′,5′-monophosphate (cGMP)-mediated mechanisms play an important role in vasodilation and blood pressure regulation. We investigated basal…”
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Reciprocal regulation of cyclic GMP content by cyclic GMP‐phosphodiesterase and guanylate cyclase in SHR with CsA‐induced nephrotoxicity by Hosogai, Naomi, Seki, Jiro, Goto, Toshio

“…The effect of the immunosuppressant drug, cyclosporin A (CsA), on the nitric oxide (NO)‐cyclic GMP pathway was examined in spontaneous hypertensive rats (SHR)…”
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Nitric oxide dysregulates adipocytokine expression in 3T3-L1 adipocytes by Nozaki, Maiko, Fukuhara, Atsunori, Segawa, Katsumori, Okuno, Yosuke, Abe, Manabu, Hosogai, Naomi, Matsuda, Morihiro, Komuro, Ryutaro, Shimomura, Iichiro

“…Obesity is associated with infiltration of macrophages into adipose tissue, and macrophages are an important source of nitric oxide (NO). Dysregulated…”
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Evaluation of TS-1 based treatment and expression of thymidylate synthase and dihydropyrimidine dehydrogenase on oral squamous cell carcinoma by Obara, Seiji, Yamamoto, Kazumi, Hosogai, Nao, Yoshimura, Yasuro

“…Seventeen oral squamous cell carcinoma (SCC) patients underwent chemotherapy with TS-1 (8 males and 9 females, mean age; 75.1 years, range; 47–102 years). TS-1…”
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FK614, a Novel Peroxisome Proliferator-Activated Receptor γ Modulator, Induces Differential Transactivation Through a Unique Ligand-Specific Interaction With Transcriptional Coactivators by Fujimura, Takao, Sakuma, Hiroyuki, Konishi, Satoko, Oe, Tomoya, Hosogai, Naomi, Kimura, Chiaki, Aramori, Ichiro, Mutoh, Seitaro

“…Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-dependent transcriptional factor implicated in regulating adipogenesis, glucose homeostasis,…”
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Phosphodiesterase type 5 inhibition ameliorates nephrotoxicity induced by cyclosporin A in spontaneous hypertensive rats by Hosogai, Naomi, Tomita, Masayuki, Hamada, Kaori, Ogawa, Toshikazu, Hirosumi, Jiro, Manda, Toshitaka, Mutoh, Seitaro

“…Our recent study suggests that there is a reciprocal mechanism to maintain cGMP content, via both a decrease in cGMP degradation (decrease in…”
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FR226807: a potent and selective phosphodiesterase type 5 inhibitor by Hosogai, Naomi, Hamada, Kaori, Tomita, Masayuki, Nagashima, Akira, Takahashi, Tokiko, Sekizawa, Toshihiro, Mizutani, Tsuyoshi, Urano, Yasuharu, Kuroda, Akio, Sawada, Kozo, Ozaki, Tohru, Seki, Jiro, Goto, Toshio

“…We describe the pharmacological characteristics of a novel phosphodiesterase type 5 inhibitor FR226807, N-(3,4-dimethoxybenzyl)-2-{[(1…”
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Synthesis and Characterization of Orally Active Nonpeptide Vasopressin V2 Receptor Antagonists by OHKAWA, Takehiko, ZENKOH, Tatsuya, TOMITA, Masayuki, HOSOGAI, Naomi, HEMMI, Keiji, TANAKA, Hirokazu, SETOI, Hiroyuki

“…The present study was undertaken to evaluate whether a novel series of 2, 6-diaza-5-oxobicyclo[5.4.0]undeca-1(7), 8, 10-triene derivatives exhibited…”
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