Search Results - "Hosoe, K."

90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats by Nakagawa, K., Kitano, M., Kishida, H., Hidaka, T., Nabae, K., Kawabe, M., Hosoe, K.

“…Licorice flavonoid oil (LFO) is a new functional food ingredient consisting of licorice hydrophobic polyphenols in medium-chain triglycerides (MCT). As part of…”
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Genotoxicity studies on licorice flavonoid oil (LFO) by Nakagawa, K., Hidaka, T., Kitano, M., Asakura, M., Kamigaito, T., Noguchi, T., Hosoe, K.

“…Licorice flavonoid oil (LFO) is a new functional food ingredient. In this study, the genotoxicity of LFO was investigated using a test battery of three…”
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Evaluation of the mutagenic potential of ubidecarenone using three short-term assays by Kitano, M., Hosoe, K., Fukutomi, N., Hidaka, T., Ohta, R., Yamakage, K., Hara, T.

“…Addition of ubidecarenone, coenzyme Q 10 (CoQ 10), to foods has been proposed for its nutritive value. Ubidecarenone is present naturally in a number of foods,…”
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28-Day repeated dose toxicity study of dried microorganism in rats by Kitano, M., Hosoe, K., Fukutomi, N., Hidaka, T., Imai, N., Kawabe, M.

“…Ubidecarenone, also known as CoQ 10, is currently sold as a dietary supplement in the United States, with a majority of these products derived from the…”
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In vitro and in vivo activities of the benzoxazinorifamycin KRM-1648 against Mycobacterium tuberculosis by HIRATA, T, SAITO, H, TOMIOKA, H, SATO, K, JIDOI, J, HOSOE, K, HIDAKA, T

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In vitro antimycobacterial activities of newly synthesized benzoxazinorifamycins by SAITO, H, TOMIOKA, H, SATO, K, EMORI, M, YAMANE, T, YAMASHITA, K, HOSOE, K, HIDAKA, T

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Identification of enzymes responsible for rifalazil metabolism in human liver microsomes by Mae, T., Inaba, T., Konishi, E., Hosoe, K.

“…1. The major metabolites of rifalazil in human are 25-deacetyl-rifalazil and 32- hydroxy-rifalazil. Biotransformation to these metabolites in pooled human…”
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Isolation and identification of major metabolites of rifalazil in mouse and human by Mae, T., Konishi, E., Hosoe, K., Hidaka, T.

“…1. Three metabolites of rifalazil have been isolated from dog urine and identified as 25-deacetyl-rifalazil, 30-hydroxy-rifalazil and…”
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Chemotherapeutic efficacy of a newly synthesized benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex infection induced in mice by TOMIOKA, H, SAITO, H, YAMANE, T, YAMASHITA, K, HOSOE, K, FUJII, K, HIDAKA, T

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Mechanism of action of antimycobacterial activity of the new benzoxazinorifamycin KRM-1648 by Fujii, K, Saito, H, Tomioka, H, Mae, T, Hosoe, K

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Effect of a new rifamycin derivative, rifalazil, on liver microsomal enzyme induction in rat and dog by MAE, T., HOSOE, K., YAMAMOTO, T., HIDAKA, T., OHASHI, T., KLEEMAN, J. M., ADAMS, P. E.

“…1. The effect of a new rifamycin derivative, rifalazil (KRM-1648), on liver microsomal enzyme induction was studied in rat and dog with repeated oral…”
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Pharmacokinetics of KRM-1648, a new benzoxazinorifamycin, in rats and dogs by HOSOE, K, MAE, T, KONISHI, E, FUJII, K, YAMASHITA, K, YAMANE, T, HIDAKA, T, OHASHI, T

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Brominated dioxin-like compounds: in vitro assessment in comparison to classical dioxin-like compounds and other polyaromatic compounds by Behnisch, Peter Alexander, Hosoe, Kazunori, Sakai, Shin-ichi

“…Recently, several countries agreed to adopt the Stockholm convention on persistent organic pollutants (POPs). One future obligation will be to add other POPs…”
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Development of Fiber-Optic Voltage Sensors and Magnetic-Field Sensors by Mitsui, T., Hosoe, K., Usami, H., Miyamoto, S.

“…The principle, temperature characteristics, and frequency characteristics of fiber-optic voltage sensors and magnetic field sensors are reported, along with…”
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In vitro metabolism of a rifamycin derivative by animal and human liver microsomes, whole blood and expressed human CYP3A isoform by Mae, T, Hosoe, K, Fujii, K, Yamashita, K, Yamane, T, Hidaka, T, Ohashi, T

“…1. In vitro metabolism of a rifamycin derivative, benzoxazinorifamycin KRM-1648, was studied using mouse, rat, guinea pig, dog, monkey and human liver…”
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Identification and antimicrobial activity of urinary metabolites of a rifamycin derivative in dog by Hosoe, K, Mae, T, Yamashita, K, Fujii, K, Yamane, T, Hidaka, T, Ohashi, T

“…1. Three metabolites of the antimicrobial agent 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin (KRM-1648) were isolated from dog urine obtained…”
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Bioanalytical screening methods for dioxins and dioxin-like compounds — a review of bioassay/biomarker technology by Behnisch, Peter A, Hosoe, Kazunori, Sakai, Shin-ichi

“…Determination of environmental pollutants utilizing biodetectors such as bioassays, biomarkers, enzyme immunoassays (EIAs), or other bioanalytical tools is a…”
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Food content of ubiquinol-10 and ubiquinone-10 in the Japanese diet by Kubo, Hiroshi, Fujii, Kenji, Kawabe, Taizo, Matsumoto, Shuka, Kishida, Hideyuki, Hosoe, Kazunori

“…Seventy food items (8 types of meat, 16 types of fish and shellfish, 21 vegetables, 7 fruits, 6 pulses, 3 potatoes, 3 dairy products and 6 others) were…”
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Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice by Yan, Jingmin, Fujii, Kenji, Yao, Junjie, Kishida, Hideyuki, Hosoe, Kazunori, Sawashita, Jinko, Takeda, Toshio, Mori, Masayuki, Higuchi, Keiichi

“…The SAMP1 strain is a mouse model for accelerated senescence and severe senile amyloidosis. We determined whether supplementation with coenzyme Q10 (CoQ10)…”
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Combinatorial bio/chemical analysis of dioxin and dioxin-like compounds in waste recycling, feed/food, humans/wildlife and the environment by Behnisch, Peter A, Hosoe, Kazunori, Sakai, Shin-ichi

“…The present review describes international activities using bioassays/biomarkers in combination with chemical analysis to measure the effects of dioxin and…”
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