Search Results - "Hosking, Louise K"

Multipoint Linkage-Disequilibrium Mapping Narrows Location Interval and Identifies Mutation Heterogeneity by Morris, Andrew P., Whittaker, John C., Xu, Chun-Fang, Hosking, Louise K., Balding, David J.

“…Single-nucleotide polymorphism (SNP) genotypes were recently examined in an 890-kb region flanking the human gene CYP2D6. Single-marker and haplotype-based…”
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Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Vasist Johnson, Lakshmi, Fletcher, Paul C, Bullmore, Edward T

“…The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The…”
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Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Johnson, Lakshmi Vasist, Fletcher, Paul C, Bullmore, Edward T

“…This corrects the article DOI: 10.1038/npp.2016.60…”
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Single-Nucleotide Polymorphism Alleles in the Insulin Receptor Gene Are Associated with Typical Migraine by McCarthy, Linda C., Hosford, David A., Riley, John H., Bird, Michael I., White, Nicola J., Hewett, Duncan R., Peroutka, Stephen J., Griffiths, Lyn R., Boyd, Pete R., Lea, Rod A., Bhatti, Shahid M., Hosking, Louise K., Hood, Chris M., Jones, Keith W., Handley, Abigail R., Rallan, Raj, Lewis, Karen F., Yeo, Astrid J.M., Williams, Pauline M., Priest, Richard C., Khan, Parveen, Donnelly, Christine, Lumsden, Sheena M., O'Sullivan, Jennifer, See, Chee Gee, Smart, Devi H., Shaw-Hawkins, Sue, Patel, Jaymini, Langrish, Tony C., Feniuk, Wasyl, Knowles, Richard G., Thomas, Malcolm, Libri, Vincenzo, Montgomery, Doug S., Manasco, Penny K., Xu, Chun-Fang, Dykes, Colin, Humphrey, Patrick P.A., Roses, Allen D., Purvis, Ian J.

“…We have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the…”
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Opioid Antagonists and the A118G Polymorphism in the [mu]-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Johnson, Lakshmi Vasist, Fletcher, Paul C, Bullmore, Edward T

“…This corrects the article DOI: 10.1038/npp.2016.60…”
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Erratum: Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Johnson, Lakshmi Vasist, Fletcher, Paul C, Bullmore, Edward T

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Anomalous relationship between cisplatin sensitivity and the formation and removal of platinum-DNA adducts in two human ovarian carcinoma cell lines in vitro by Shellard, S A, Hosking, L K, Hill, B T

“…Two human ovarian tumor cell lines (SK-OV-3 and TR175), established from patients previously treated with alkylating agents, but not with cisplatin, expressed…”
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Opioid Antagonists and the A118G Polymorphism in the [mu]-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Vasist Johnson, Lakshmi, Fletcher, Paul C, Bullmore, Edward T

“…The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The…”
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Dominant expression of multiple drug resistance after in vitro X-irradiation exposure in intraspecific Chinese hamster ovary hybrid cells by McClean, S, Hosking, L K, Hill, B T

“…Exposure of Chinese hamster ovary (CHO) cells to fractionated x irradiation in vitro has led to expression of a distinctive multiple-drug-resistant phenotype…”
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Characterization of a cisplatin-resistant human ovarian carcinoma cell line expressing cross-resistance to 5-fluorouracil but collateral sensitivity to methotrexate by HILL, B. T, SHELLARD, S. A, HOSKING, L. K, DEMPKE, W. C. M, FICHTINGER, A. M. J, TAKESHI, S, TONE, T, SCANLON, K. J, WHELAN, R. D. H

“…In vitro exposure of the TR170 ovarian carcinoma cell line to six intermittent 24-h treatments with a 90% inhibitory concentration of cisplatin (CDDP) (0.15…”
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Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublinesin vitro by Hill, Bridget T., Whelan, Richard D. H., Shellard, Sharon A., McClean, Siobhan, Hosking, Louise K.

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A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma by PILLAI, Sreekumar G, COUSENS, Diane J, SARAU, Henry M, SCHMIDT, Dulcie B, SPRANKLE, Catherine S, BLUMENTHAL, Malcolm N, VESTBO, Jorgen, KENNEDY-WILSON, Karen, WIXTED, William E, WAGNER, Michael J, ANDERSON, Wayne H, IGNAR, Diane M, BARNES, Ashley A, BUCKLEY, Peter T, CHIANO, Mathias N, HOSKING, Louise K, CAMERON, Lee-Ann, FLING, Mary E, FOLEY, James J, GREEN, Andrew

“…Cysteinyl leukotrienes (CYSLTR) are potent biological mediators in the pathophysiology of asthma for which two receptors have been characterized, CYSLTR1 and…”
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Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublines in vitro by HILL, B. T, WHELAN, R. D. H, SHELLARD, S. A, MCCLEAN, S, HOSKING, L. K

“…The in vitro cytotoxic effects of docetaxel (Taxotere; RP56976, NSC688503) proved both time and concentration dependent. Amongst thirteen human cell lines from…”
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Overexpression of P-glycoprotein in mammalian tumor cell lines after fractionated X irradiation in vitro by Hill, B T, Deuchars, K, Hosking, L K, Ling, V, Whelan, R D

“…We observed that in vitro exposure of mammalian tumor cells to fractionated x irradiation results in the expression of drug resistance. The cause of this…”
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An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines by Hosking, L K, Whelan, R D, Shellard, S A, Bedford, P, Hill, B T

“…Glutathione and its associated enzyme activities have been quantitated in a series of human tumour continuous cell lines expressing a range of in vitro…”
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Single-Nucleotide Polymorphism Alleles in the Insulin Receptor Gene Are Associated with Typical Migraine by McCarthy, Linda C., Hosford, David A., Riley, John H., Bird, Michael I., White, Nicola J., Hewett, Duncan R., Peroutka, Stephen J., Griffiths, Lyn R., Boyd, Pete R., Lea, Rod A., Bhatti, Shahid M., Hosking, Louise K., Hood, Chris M., Jones, Keith W., Handley, Abigail R., Rallan, Raj, Lewis, Karen F., Yeo, Astrid J.M., Williams, Pauline M., Priest, Richard C., Khan, Parveen, Donnelly, Christine, Lumsden, Sheena M., O'Sullivan, Jennifer, See, Chee Gee, Smart, Devi H., Shaw-Hawkins, Sue, Patel, Jaymini, Langrish, Tony C., Feniuk, Wasyl, Knowles, Richard G., Thomas, Malcolm, Libri, Vincenzo, Montgomery, Doug S., Manasco, Penny K., Xu, Chun-Fang, Dykes, Colin, Humphrey, Patrick P.A., Roses, Allen D., Purvis, Ian J.

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Over-expression of P-glycoprotein and glutathione S-transferase pi in MCF-7 cells selected for vincristine resistance in vitro by Whelan, R D, Waring, C J, Wolf, C R, Hayes, J D, Hosking, L K, Hill, B T

“…This study has provided evidence that exposure of the wild-type MCF-7 human breast carcinoma cell line to the mutagen ethyl methane sulphonate (EMS), followed…”
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Differential effectiveness of a range of novel drug-resistance modulators, relative to verapamil, in influencing vinblastine or teniposide cytotoxicity in human lymphoblastoid CCRF-CEM sublines expressing classic or atypical multidrug resistance by Hill, B T, Hosking, L K

“…A series of five potential modulators of resistance were tested for their relative ability, as compared with verapamil, to sensitize CEM lymphoblastoid…”
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Enhanced DNA repair and tolerance of DNA damage associated with resistance to cis-diammine-dichloroplatinum (II) after in vitro exposure of a human teratoma cell line to fractionated X-irradiation by Hill, B T, Shellard, S A, Hosking, L K, Fichtinger-Schepman, A M, Bedford, P

“…In vitro exposure of a human testicular teratoma continuous cell line to fractionated X-irradiation resulted in the expression of resistance to cisplatin. In…”
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Mechanisms associated with the expression of cisplatin resistance in a human ovarian tumor cell line following exposure to fractionated X-irradiation in vitro by Dempke, W C, Shellard, S A, Hosking, L K, Fichtinger-Schepman, A M, Hill, B T

“…Interactions between cisplatin (CDDP) and irradiation are of potential significance for the combined modality treatment of cancer. Previous data have indicated…”
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