Search Results - "Hosking, Louise"

No evidence of large genetic effects on steroid response in asthma patients by Mosteller, Michael, PhD, Hosking, Louise, BSc, Murphy, Kay, PhD, Shen, Judong, PhD, Song, Kijoung, PhD, Nelson, Matthew, PhD, Ghosh, Soumitra, PhD, MD

“…Background Inhaled corticosteroids (ICSs) are considered the most effective anti-inflammatory therapy for asthma control and management; however, there is…”
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Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects by Ali, Zahid, Laurijssens, Bart, Ostenfeld, Thor, McHugh, Simon, Stylianou, Anastasia, Scott‐Stevens, Paul, Hosking, Louise, Dewit, Odile, Richardson, Jill C., Chen, Chao

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • P2X7 receptors are involved in the production of pro‐inflammatory cytokines, such as Il‐1β, by central and…”
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GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma by Hosking, Louise, BSc, Bleecker, Eugene, MD, Ghosh, Soumitra, MD, PhD, Yeo, Astrid, PhD, Jacques, Loretta, PhD, Mosteller, Michael, PhD, Meyers, Deborah, PhD

“…An association between genetic variation in GLCCI1 and response to ICS therapy in non-Hispanic white subjects with asthma was observed by Tantisira et al.5…”
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Detection of genotyping errors by Hardy-Weinberg equilibrium testing by HOSKING, Louise, LUMSDEN, Sheena, LEWIS, Karen, YEO, Astrid, MCCARTHY, Linda, BANSAL, Aruna, RILEY, John, PURVIS, Ian, XU, Chun-Fang

“…Genotyping data sets may contain errors that, in some instances, lead to false conclusions. Deviation from Hardy-Weinberg equilibrium (HWE) in random samples…”
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Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Vasist Johnson, Lakshmi, Fletcher, Paul C, Bullmore, Edward T

“…The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The…”
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Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Johnson, Lakshmi Vasist, Fletcher, Paul C, Bullmore, Edward T

“…This corrects the article DOI: 10.1038/npp.2016.60…”
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Single-Nucleotide Polymorphism Alleles in the Insulin Receptor Gene Are Associated with Typical Migraine by McCarthy, Linda C., Hosford, David A., Riley, John H., Bird, Michael I., White, Nicola J., Hewett, Duncan R., Peroutka, Stephen J., Griffiths, Lyn R., Boyd, Pete R., Lea, Rod A., Bhatti, Shahid M., Hosking, Louise K., Hood, Chris M., Jones, Keith W., Handley, Abigail R., Rallan, Raj, Lewis, Karen F., Yeo, Astrid J.M., Williams, Pauline M., Priest, Richard C., Khan, Parveen, Donnelly, Christine, Lumsden, Sheena M., O'Sullivan, Jennifer, See, Chee Gee, Smart, Devi H., Shaw-Hawkins, Sue, Patel, Jaymini, Langrish, Tony C., Feniuk, Wasyl, Knowles, Richard G., Thomas, Malcolm, Libri, Vincenzo, Montgomery, Doug S., Manasco, Penny K., Xu, Chun-Fang, Dykes, Colin, Humphrey, Patrick P.A., Roses, Allen D., Purvis, Ian J.

“…We have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the…”
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Multipoint Linkage-Disequilibrium Mapping Narrows Location Interval and Identifies Mutation Heterogeneity by Morris, Andrew P., Whittaker, John C., Xu, Chun-Fang, Hosking, Louise K., Balding, David J.

“…Single-nucleotide polymorphism (SNP) genotypes were recently examined in an 890-kb region flanking the human gene CYP2D6. Single-marker and haplotype-based…”
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GENETIC VARIANTS DO NOT PREDICT ACUTE COPD EXACERBATIONS OR TREATMENT RESPONSE TO FLUTICASONE FUROATE/UMECLIDINIUM/VILANTEROL (FF/UMEC/VI) AND ITS COMPONENTS by Hosking, Louise, Yeo, Astrid, Hoffman, Joshua, Chiano, Mathias, Fraser, Dana, Ghosh, Soumitra, Lipson, David, Martin, Neil, Condreay, Lynn, Cox, Charles, StJean, Pamela

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Genetics plays a limited role in predicting chronic obstructive pulmonary disease treatment response and exacerbation by Hosking, Louise, Yeo, Astrid, Hoffman, Joshua, Chiano, Mathias, Fraser, Dana, Ghosh, Soumitra, Lipson, David A., Martin, Neil, Condreay, Lynn D., Cox, Charles, St Jean, Pamela

“…Combination treatments, targeting multiple disease processes, benefit subjects with acute exacerbation of chronic obstructive pulmonary disease (AECOPD)…”
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Capitalizing on the wealth of chemical data in the accretionary structures of aquatic taxa: Opportunities from across the tree of life by Doubleday, Zoë A., Hosking, Louise, Willoughby, Jasper, Dias, Minoli, Leclerc, Natasha, Nikolajew, Shanie Brault, Peharda, Melita, Rézio, Arieli Tristão, Trueman, Clive

“…Abstract Aquatic organisms are natural data loggers and record chemical variations within hardened accretionary structures like shells and teeth. Chemical…”
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GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white asthma subjects by Hosking, Louise, Bleecker, Eugene, Ghosh, Soumitra, Yeo, Astrid, Jacques, Loretta, Mosteller, Michael, Meyers, Deborah

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Opioid Antagonists and the A118G Polymorphism in the [mu]-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Johnson, Lakshmi Vasist, Fletcher, Paul C, Bullmore, Edward T

“…This corrects the article DOI: 10.1038/npp.2016.60…”
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Erratum: Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Johnson, Lakshmi Vasist, Fletcher, Paul C, Bullmore, Edward T

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Anomalous relationship between cisplatin sensitivity and the formation and removal of platinum-DNA adducts in two human ovarian carcinoma cell lines in vitro by Shellard, S A, Hosking, L K, Hill, B T

“…Two human ovarian tumor cell lines (SK-OV-3 and TR175), established from patients previously treated with alkylating agents, but not with cisplatin, expressed…”
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Effects of enzyme inducers efavirenz and tipranavir/ritonavir on the pharmacokinetics of the HIV integrase inhibitor dolutegravir by Song, Ivy, Borland, Julie, Chen, Shuguang, Guta, Phyllis, Lou, Yu, Wilfret, David, Wajima, Toshihiro, Savina, Paul, Peppercorn, Amanda, Castellino, Stephen, Wagner, David, Hosking, Louise, Mosteller, Michael, Rubio, Justin P., Piscitelli, Stephen C.

“…Purpose Dolutegravir (DTG) is an unboosted, integrase inhibitor for the treatment of HIV infection. Two studies evaluated the effects of efavirenz (EFV) and…”
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Opioid Antagonists and the A118G Polymorphism in the [mu]-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Vasist Johnson, Lakshmi, Fletcher, Paul C, Bullmore, Edward T

“…The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The…”
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Dominant expression of multiple drug resistance after in vitro X-irradiation exposure in intraspecific Chinese hamster ovary hybrid cells by McClean, S, Hosking, L K, Hill, B T

“…Exposure of Chinese hamster ovary (CHO) cells to fractionated x irradiation in vitro has led to expression of a distinctive multiple-drug-resistant phenotype…”
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Are you managing the transition to CDM 2015? by Hosking, Louise

“…Chartered Safety & Health Practitioner Louise Hosking offers advice on managing some of the challenges posed by the new CDM regulations…”
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Characterization of a cisplatin-resistant human ovarian carcinoma cell line expressing cross-resistance to 5-fluorouracil but collateral sensitivity to methotrexate by HILL, B. T, SHELLARD, S. A, HOSKING, L. K, DEMPKE, W. C. M, FICHTINGER, A. M. J, TAKESHI, S, TONE, T, SCANLON, K. J, WHELAN, R. D. H

“…In vitro exposure of the TR170 ovarian carcinoma cell line to six intermittent 24-h treatments with a 90% inhibitory concentration of cisplatin (CDDP) (0.15…”
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