Search Results - "Hoskens, Hanne"

Shared heritability of human face and brain shape by Naqvi, Sahin, Sleyp, Yoeri, Hoskens, Hanne, Indencleef, Karlijne, Spence, Jeffrey P., Bruffaerts, Rose, Radwan, Ahmed, Eller, Ryan J., Richmond, Stephen, Shriver, Mark D., Shaffer, John R., Weinberg, Seth M., Walsh, Susan, Thompson, James, Pritchard, Jonathan K., Sunaert, Stefan, Peeters, Hilde, Wysocka, Joanna, Claes, Peter

“…Evidence from model organisms and clinical genetics suggests coordination between the developing brain and face, but the role of this link in common genetic…”
Get full text

Sources of variation in the 3dMDface and Vectra H1 3D facial imaging systems by White, Julie D., Ortega-Castrillon, Alejandra, Virgo, Ciara, Indencleef, Karlijne, Hoskens, Hanne, Shriver, Mark D., Claes, Peter

“…As technology advances and collaborations grow, our ability to finely quantify and explore morphological variation in 3D structures can enable important…”
Get full text

Hybrid autoencoder with orthogonal latent space for robust population structure inference by Yuan, Meng, Hoskens, Hanne, Goovaerts, Seppe, Herrick, Noah, Shriver, Mark D., Walsh, Susan, Claes, Peter

“…Analysis of population structure and genomic ancestry remains an important topic in human genetics and bioinformatics. Commonly used methods require…”
Get full text

Exploring regional aspects of 3D facial variation within European individuals by Wilke, Franziska, Herrick, Noah, Matthews, Harold, Hoskens, Hanne, Singh, Sylvia, Shaffer, John R., Weinberg, Seth M., Shriver, Mark D., Claes, Peter, Walsh, Susan

“…Facial ancestry can be described as variation that exists in facial features that are shared amongst members of a population due to environmental and genetic…”
Get full text

Joint multi-ancestry and admixed GWAS reveals the complex genetics behind human cranial vault shape by Goovaerts, Seppe, Hoskens, Hanne, Eller, Ryan J., Herrick, Noah, Musolf, Anthony M., Justice, Cristina M., Yuan, Meng, Naqvi, Sahin, Lee, Myoung Keun, Vandermeulen, Dirk, Szabo-Rogers, Heather L., Romitti, Paul A., Boyadjiev, Simeon A., Marazita, Mary L., Shaffer, John R., Shriver, Mark D., Wysocka, Joanna, Walsh, Susan, Weinberg, Seth M., Claes, Peter

“…The cranial vault in humans is highly variable, clinically relevant, and heritable, yet its genetic architecture remains poorly understood. Here, we conduct a…”
Get full text

Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations by Liu, Chenxing, Lee, Myoung Keun, Naqvi, Sahin, Hoskens, Hanne, Liu, Dongjing, White, Julie D, Indencleef, Karlijne, Matthews, Harold, Eller, Ryan J, Li, Jiarui, Mohammed, Jaaved, Swigut, Tomek, Richmond, Stephen, Manyama, Mange, Hallgrímsson, Benedikt, Spritz, Richard A, Feingold, Eleanor, Marazita, Mary L, Wysocka, Joanna, Walsh, Susan, Shriver, Mark D, Claes, Peter, Weinberg, Seth M, Shaffer, John R

“…Facial morphology is highly variable, both within and among human populations, and a sizable portion of this variation is attributable to genetics. Previous…”
Get full text

3D facial phenotyping by biometric sibling matching used in contemporary genomic methodologies by Hoskens, Hanne, Liu, Dongjing, Naqvi, Sahin, Lee, Myoung Keun, Eller, Ryan J, Indencleef, Karlijne, White, Julie D, Li, Jiarui, Larmuseau, Maarten H D, Hens, Greet, Wysocka, Joanna, Walsh, Susan, Richmond, Stephen, Shriver, Mark D, Shaffer, John R, Peeters, Hilde, Weinberg, Seth M, Claes, Peter

“…The analysis of contemporary genomic data typically operates on one-dimensional phenotypic measurements (e.g. standing height). Here we report on a…”
Get full text

netMUG: a novel network-guided multi-view clustering workflow for dissecting genetic and facial heterogeneity by Li, Zuqi, Melograna, Federico, Hoskens, Hanne, Duroux, Diane, Marazita, Mary L, Walsh, Susan, Weinberg, Seth M, Shriver, Mark D, Müller-Myhsok, Bertram, Claes, Peter, Van Steen, Kristel

“…Multi-view data offer advantages over single-view data for characterizing individuals, which is crucial in precision medicine toward personalized prevention,…”
Get full text

Robust genome-wide ancestry inference for heterogeneous datasets: illustrated using the 1,000 genome project with 3D facial images by Li, Jiarui, Zarzar, Tomás González, White, Julie D., Indencleef, Karlijne, Hoskens, Hanne, Matthews, Harry, Nauwelaers, Nele, Zaidi, Arslan, Eller, Ryan J., Herrick, Noah, Günther, Torsten, Svensson, Emma M., Jakobsson, Mattias, Walsh, Susan, Van Steen, Kristel, Shriver, Mark D., Claes, Peter

“…Estimates of individual-level genomic ancestry are routinely used in human genetics, and related fields. The analysis of population structure and genomic…”
Get full text

SNPs Associated With Testosterone Levels Influence Human Facial Morphology by Roosenboom, Jasmien, Indencleef, Karlijne, Lee, Myoung Keun, Hoskens, Hanne, White, Julie D, Liu, Dongjing, Hecht, Jacqueline T, Wehby, George L, Moreno, Lina M, Hodges-Simeon, Carolyn, Feingold, Eleanor, Marazita, Mary L, Richmond, Stephen, Shriver, Mark D, Claes, Peter, Shaffer, John R, Weinberg, Seth M

“…Many factors influence human facial morphology, including genetics, age, nutrition, biomechanical forces, and endocrine factors. Moreover, facial features…”
Get full text

Six NSCL/P Loci Show Associations With Normal-Range Craniofacial Variation by Indencleef, Karlijne, Roosenboom, Jasmien, Hoskens, Hanne, White, Julie D, Shriver, Mark D, Richmond, Stephen, Peeters, Hilde, Feingold, Eleanor, Marazita, Mary L, Shaffer, John R, Weinberg, Seth M, Hens, Greet, Claes, Peter

“…Orofacial clefting is one of the most prevalent craniofacial malformations. Previous research has demonstrated that unaffected relatives of patients with…”
Get full text

The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation by Indencleef, Karlijne, Hoskens, Hanne, Lee, Myoung Keun, White, Julie D, Liu, Chenxing, Eller, Ryan J, Naqvi, Sahin, Wehby, George L, Moreno Uribe, Lina M, Hecht, Jacqueline T, Long, Jr, Ross E, Christensen, Kaare, Deleyiannis, Frederic W, Walsh, Susan, Shriver, Mark D, Richmond, Stephen, Wysocka, Joanna, Peeters, Hilde, Shaffer, John R, Marazita, Mary L, Hens, Greet, Weinberg, Seth M, Claes, Peter

“…Unaffected relatives of individuals with non-syndromic cleft lip with or without cleft palate (NSCL/P) show distinctive facial features. The presence of this…”
Get full text

Spatially Dense 3D Facial Heritability and Modules of Co-heritability in a Father-Offspring Design by Hoskens, Hanne, Li, Jiarui, Indencleef, Karlijne, Gors, Dorothy, Larmuseau, Maarten H D, Richmond, Stephen, Zhurov, Alexei I, Hens, Greet, Peeters, Hilde, Claes, Peter

“…The human face is a complex trait displaying a strong genetic component as illustrated by various studies on facial heritability. Most of these start from…”
Get full text

Insights into the genetic architecture of the human face by White, Julie D., Indencleef, Karlijne, Naqvi, Sahin, Eller, Ryan J., Hoskens, Hanne, Roosenboom, Jasmien, Lee, Myoung Keun, Li, Jiarui, Mohammed, Jaaved, Richmond, Stephen, Quillen, Ellen E., Norton, Heather L., Feingold, Eleanor, Swigut, Tomek, Marazita, Mary L., Peeters, Hilde, Hens, Greet, Shaffer, John R., Wysocka, Joanna, Walsh, Susan, Weinberg, Seth M., Shriver, Mark D., Claes, Peter

“…The human face is complex and multipartite, and characterization of its genetic architecture remains challenging. Using a multivariate genome-wide association…”
Get full text

Precise modulation of transcription factor levels identifies features underlying dosage sensitivity by Naqvi, Sahin, Kim, Seungsoo, Hoskens, Hanne, Matthews, Harold S., Spritz, Richard A., Klein, Ophir D., Hallgrímsson, Benedikt, Swigut, Tomek, Claes, Peter, Pritchard, Jonathan K., Wysocka, Joanna

“…Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling such…”
Get full text

Decoding the Human Face: Progress and Challenges in Understanding the Genetics of Craniofacial Morphology by Naqvi, Sahin, Hoskens, Hanne, Wilke, Franziska, Weinberg, Seth M, Shaffer, John R, Walsh, Susan, Shriver, Mark D, Wysocka, Joanna, Claes, Peter

“…Variations in the form of the human face, which plays a role in our individual identities and societal interactions, have fascinated scientists and artists…”
Get full text

Toward 3D facial analysis for recognizing Mendelian causes of autism spectrum disorder by Sleyp, Yoeri, Matthews, Harold S., Vanneste, Michiel, Vandenhove, Laura, Delanote, Valentine, Hoskens, Hanne, Indencleef, Karlijne, Teule, Hanne, Larmuseau, Maarten H. D., Steyaert, Jean, Devriendt, Koenraad, Claes, Peter, Peeters, Hilde

“…Recognizing Mendelian causes is crucial in molecular diagnostics and counseling for patients with autism spectrum disorder (ASD). We explored facial…”
Get full text

Quantitative analysis of facial shape in children to support respirator design by Nemeth, Christopher, Hoskens, Hanne, Wilson, Graham, Jones, Mike, DiPietrantonio, Josef, Salami, Bukola, Harnish, Del, Claes, Peter, Weinberg, Seth M., Shriver, Mark D., Hallgrímsson, Benedikt

“…The COVID-19 pandemic demonstrated the need for respiratory protection against airborne pathogens. Respirator options for children are limited, and existing…”
Get full text

TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells by Bertol, Jessica W, Johnston, Shelby, Ahmed, Rabia, Xie, Victoria K, Hubka, Kelsea M, Cruz, Lissette, Nitschke, Larissa, Stetsiv, Marta, Goering, Jeremy P, Nistor, Paul, Lowell, Sally, Hoskens, Hanne, Claes, Peter, Weinberg, Seth M, Saadi, Irfan, Farach-Carson, Mary C, Fakhouri, Walid D

“…Cell fate determination is a necessary and tightly regulated process for producing different cell types and structures during development. Cranial neural crest…”
Get full text

An interactive atlas of three-dimensional syndromic facial morphology by Aponte, J. David, Bannister, Jordan J., Hoskens, Hanne, Matthews, Harold, Katsura, Kaitlin, Da Silva, Cassidy, Cruz, Tim, Pilz, Julie H.M., Spritz, Richard A., Forkert, Nils D., Claes, Peter, Bernier, Francois P., Klein, Ophir D., Katz, David C., Hallgrímsson, Benedikt

“…Craniofacial phenotyping is critical for both syndrome delineation and diagnosis because craniofacial abnormalities occur in 30% of characterized genetic…”
Get full text