Search Results - "Hosey, Chelsea M."

Pediatric growth patterns in youth‐onset type 2 diabetes mellitus: Implications for physiologically‐based pharmacokinetic models by Hosey, Chelsea M., Halpin, Kelsee, Shakhnovich, Valentina, Bi, Chengpeng, Sweeney, Brooke, Yan, Yun, Leeder, J. Steven

“…An accurate understanding of the changes in height and weight of children with age is critical to the development of models predicting drug concentrations in…”
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BDDCS, the Rule of 5 and drugability by Benet, Leslie Z., Hosey, Chelsea M., Ursu, Oleg, Oprea, Tudor I.

“…The Rule of 5 methodology appears to be as useful today in defining drugability as when it was proposed, but recognizing that the database that we used…”
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BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs by Hosey, Chelsea M., Chan, Rosa, Benet, Leslie Z.

“…The biopharmaceutics drug disposition classification system was developed in 2005 by Wu and Benet as a tool to predict metabolizing enzyme and drug transporter…”
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Predicting the Extent of Metabolism Using in Vitro Permeability Rate Measurements and in Silico Permeability Rate Predictions by Hosey, Chelsea M, Benet, Leslie Z

“…The Biopharmaceutics Drug Disposition Classification System (BDDCS) can be utilized to predict drug disposition, including interactions with other drugs and…”
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Predicting when Biliary Excretion of Parent Drug is a Major Route of Elimination in Humans by Hosey, Chelsea M., Broccatelli, Fabio, Benet, Leslie Z.

“…Biliary excretion is an important route of elimination for many drugs, yet measuring the extent of biliary elimination is difficult, invasive, and variable…”
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Pediatric Clinical Endpoint and Pharmacodynamic Biomarkers: Limitations and Opportunities by Dinh, Jean C., Hosey-Cojocari, Chelsea M., Jones, Bridgette L.

“…Medical research in children typically lags behind that of adult research in both quantity and quality. The conduct of rigorous clinical trials in children can…”
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